Patents by Inventor Zhenglin Hou
Zhenglin Hou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210274739Abstract: Compositions and methods for generating maize plants that exhibit resistance to northern leaf blight are provided herein. Polynucleotides encoding a polypeptide that confers resistance to northern leaf blight, polynucleotide constructs comprising such, and maize plants comprising the polynucleotide constructs are provided.Type: ApplicationFiled: May 13, 2021Publication date: September 9, 2021Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: ZHENGLIN HOU, APRIL L LEONARD, BAILIN LI, GIRMA M TABOR
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Patent number: 11091771Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling, inhibiting growth or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: GrantFiled: May 8, 2019Date of Patent: August 17, 2021Inventors: Ruth Cong, Jingtong Hou, Zhenglin Hou, Phillip A. Patten, Takashi Yamamoto
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Publication number: 20210180079Abstract: Provided are compositions comprising polynucleotides encoding glutamine synthetase (GS) polypeptides having improved properties, such as increased enzymatic activity and/or increased thermostability. Also provided are recombinant DNA constructs, plants, plant cells, seed, grain comprising the polynucleotides. Additionally, various methods of employing the polynucleotides in plants, such as methods for increasing GS activity in a plant, methods for increase seed protein content in a seed of a plant, and methods for increasing yield of a plant, are also provided herein.Type: ApplicationFiled: May 20, 2019Publication date: June 17, 2021Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: STEVEN HENRY BASS, ERICKA BERMUDEZ, ZHENGLIN HOU, SHAI LAWIT, MARIAN BEECHER SANDOVAL, BO SHEN, PETER THELEN, YANG WANG, ROBERT W WILLIAMS, JINGRUI WU, JUN ZHANG
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Publication number: 20210171971Abstract: Provided are compositions comprising polynucleotides encoding polypeptides. Also provided are recombinant DNA constructs, plants, plant cells, seed, grain comprising the polynucleotides, and plants, plant cells, seed, grain comprising a genetic modification at a genomic locus encoding a polypeptide. Additionally, various methods of employing the polynucleotides and genetic modifications in plants, such as methods for modulating expression level in a plant and methods for increasing yield of a plant are also provided herein.Type: ApplicationFiled: April 16, 2019Publication date: June 10, 2021Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: KRISTIN HAUG COLLET, ZHENGLIN HOU, SHAI LAWIT, ROSANA MELO, NICHOLAS MONGAR, JOHN VAN HEMERT, JINGRUI WU, WENGANG ZHOU
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Publication number: 20210163908Abstract: Compositions and methods are provided for genome modification of a target sequence in the genome of a cell, using a novel Cas endonuclease. The methods and compositions employ a guide polynucleotide/endonuclease system to provide an effective system for modifying or altering target sequences within the genome of a cell or organism. Also provided are novel effectors and endonuclease systems and elements comprising such systems, such as guide polynucleotide/endonuclease systems comprising an endonuclease. Compositions and methods are also provided for guide polynucleotide/endonuclease systems comprising at least one endonuclease, optionally covalently or non-covalently linked to, or assembled with, at least one additional protein subunit, and for compositions and methods for direct delivery of endonucleases as ribonucleotide proteins.Type: ApplicationFiled: January 21, 2021Publication date: June 3, 2021Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: ZHENGLIN HOU, TAUTVYDAS KARVELIS, VIRGINIJUS SIKSNYS, JOSHUA K YOUNG
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Publication number: 20210139874Abstract: Compositions and methods are provided for genome modification of a target sequence in the genome of a cell, using a novel Cas endonuclease. The methods and compositions employ a guide polynucleotide/endonuclease system to provide an effective system for modifying or altering target sequences within the genome of a cell or organism. Also provided are novel effectors and endonuclease systems and elements comprising such systems, such as guide polynucleotide/endonuclease systems comprising an endonuclease. Compositions and methods are also provided for guide polynucleotide/endonuclease systems comprising at least one endonuclease, optionally covalently or non-covalently linked to, or assembled with, at least one additional protein subunit, and for compositions and methods for direct delivery of endonucleases as ribonucleotide proteins.Type: ApplicationFiled: January 21, 2021Publication date: May 13, 2021Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: ZHENGLIN HOU, TAUTVYDAS KARVELIS, VIRGINIJUS SIKSNYS, JOSHUA K YOUNG
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Patent number: 10934536Abstract: Compositions and methods are provided for genome modification of a target sequence in the genome of a cell, using a novel Cas endonuclease. The methods and compositions employ a guide polynucleotide/endonuclease system to provide an effective system for modifying or altering target sequences within the genome of a cell or organism. Also provided are novel effectors and endonuclease systems and elements comprising such systems, such as guide polynucleotide/endonuclease systems comprising an endonuclease. Compositions and methods are also provided for guide polynucleotide/endonuclease systems comprising at least one endonuclease, optionally covalently or non-covalently linked to, or assembled with, at least one additional protein subunit, and for compositions and methods for direct delivery of endonucleases as ribonucleotide proteins.Type: GrantFiled: December 13, 2019Date of Patent: March 2, 2021Assignee: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Zhenglin Hou, Tautvydas Karvelis, Virginijus Siksnys, Joshua K Young
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Publication number: 20210000059Abstract: Compositions and methods for generating maize plants that exhibit resistance to northern leaf blight are provided herein. Isolated polynucleotides encoding a polypeptide that confers resistance to northern leaf blight, polynucleotide constructs comprising such, and maize plants comprising the polynucleotide constructs are provided. The methods include expressing an isolated polynucleotide in a maize cell via standard transformation methods and obtaining a maize plant from said maize cell.Type: ApplicationFiled: June 17, 2020Publication date: January 7, 2021Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: ZHENGLIN HOU, APRIL L LEONARD, BAILIN LI, GIRMA M TABOR
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Publication number: 20200190494Abstract: Compositions and methods are provided for genome modification of a target sequence in the genome of a cell, using a novel Cas endonuclease. The methods and compositions employ a guide polynucleotide/endonuclease system to provide an effective system for modifying or altering target sequences within the genome of a cell or organism. Also provided are novel effectors and endonuclease systems and elements comprising such systems, such as guide polynucleotide/endonuclease systems comprising an endonuclease. Compositions and methods are also provided for guide polynucleotide/endonuclease systems comprising at least one endonuclease, optionally covalently or non-covalently linked to, or assembled with, at least one additional protein subunit, and for compositions and methods for direct delivery of endonucleases as ribonucleotide proteins.Type: ApplicationFiled: December 13, 2019Publication date: June 18, 2020Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: ZHENGLIN HOU, TAUTVYDAS KARVELIS, VIRGINIJUS SIKSNYS, JOSHUA K YOUNG
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Publication number: 20200131529Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling, inhibiting growth or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: January 13, 2020Publication date: April 30, 2020Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: RUTH CONG, JINGTONG HOU, ZHENGLIN HOU, PHILLIP A PATTEN, TAKASHI YAMAMOTO
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Patent number: 10577626Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling, inhibiting growth or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: GrantFiled: June 20, 2018Date of Patent: March 3, 2020Assignee: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Ruth Cong, Jingtong Hou, Zhenglin Hou, Phillip A. Patten, Takashi Yamamoto
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Patent number: 10457957Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are isolated insecticidal proteins and nucleic acids. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: GrantFiled: December 13, 2017Date of Patent: October 29, 2019Assignee: PIONEER HI-BRED IINTERNATIONAL, INC.Inventors: Andre R Abad, Zhenglin Hou, Lu Liu, Brad Poland, Ute Schellenberger, Ingrid Udranszky, Jimei Wang, Jun-Zhi Wei, Thomas C Wolfe, Weiping Xie, Lan Zhou, Genhai Zhu
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Publication number: 20190309321Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling, inhibiting growth or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: May 8, 2019Publication date: October 10, 2019Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: RUTH CONG, JINGTONG HOU, ZHENGLIN HOU, PHILLIP A. PATTEN, TAKASHI YAMAMOTO
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Publication number: 20190264232Abstract: Compositions and methods are provided for novel Cas9 orthologs, including, but not limiting to, novel guide polynucleotide/Cas9 endonucleases complexes, single or dual guide RNAs, guide RNA elements, and Cas9 endonucleases. The present disclosure also describes methods for creating a double strand break in a target polynucleotide, methods for genome modification of a target sequence under various in vivo and in vitro conditions, in the genome of a cell, for gene editing, and for inserting a polynucleotide of interest into the genome of a cell. Also provided are nucleic acid constructs and cells having a modified target site or altered polynucleotide of interest produced by the methods described herein.Type: ApplicationFiled: February 22, 2019Publication date: August 29, 2019Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: ZHENGLIN HOU, JOSHUA K. YOUNG, GIEDRIUS GASIUNAS, VIRGINIJUS SIKSNYS
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Publication number: 20190256563Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: October 13, 2017Publication date: August 22, 2019Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: JENNIFER KARA BARRY, JAMES J ENGLISH, KEVIN A FENGLER, ZHENGLIN HOU, LU LIU, ERIC SCHEPERS, JEFFREY SOPA, INGRID UDRANSZKY
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Patent number: 10337026Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling, inhibiting growth or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: GrantFiled: March 13, 2018Date of Patent: July 2, 2019Assignee: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Ruth Cong, Jingtong Hou, Zhenglin Hou, Phillip A. Patten, Takashi Yamamoto
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Publication number: 20190100745Abstract: Compositions and methods are provided for genome modification of a target sequence in the genome of a cell. The methods and compositions employ a guide polynucleotide/Cas endonuclease system to provide an effective system for modifying or altering target sequences within the genome of a cell or organism. Also provided are Cas endonucleases comprising previously undefined nuclease domains and methods employing said Cas endonucleases for production of a guide polynucleotide/Cas endonuclease systems, for genome editing of a nucleotide sequence in the genome of a prokaryotic or eukaryotic cell, and/or for inserting or deleting a polynucleotide of interest into or from the genome of an organism.Type: ApplicationFiled: June 1, 2017Publication date: April 4, 2019Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: ANDREW MARK CIGAN, ZHENGLIN HOU, MATTHEW G. KING, HAINING LIN, JOSHUA K. YOUNG
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Publication number: 20190075749Abstract: Compositions and methods for generating maize plants that exhibit resistance to northern leaf blight are provided herein. Isolated polynucleotides encoding a polypeptide that confers resistance to northern leaf blight, polynucleotide constructs comprising such, and maize plants comprising the polynucleotide constructs are provided. The methods include expressing an isolated polynucleotide in a maize cell via standard transformation methods and obtaining a maize plant from said maize cell.Type: ApplicationFiled: October 14, 2016Publication date: March 14, 2019Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: ZHENGLIN HOU, APRIL LYNN LEONARD, BAILIN LI, GIRMA M TABOR
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Publication number: 20180291398Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling, inhibiting growth or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: June 20, 2018Publication date: October 11, 2018Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Ruth Cong, Jingtong Hou, Zhenglin Hou, Phillip A. Patten, Takashi Yamamoto
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Publication number: 20180216132Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling, inhibiting growth or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: March 13, 2018Publication date: August 2, 2018Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: RUTH CONG, JINGTONG HOU, ZHENGLIN HOU, PHILLIP A. PATTEN, TAKASHI YAMAMOTO