Abstract: A cutting body for a drilling tool has a center axis, at least one cutting element with at least one cutting edge, and at least one side face. The at least one side face has at least one radially inwardly directed cutout, which is designed to produce a drilled hole having an increased roughness, the cutout having precisely three open sides.

Abstract: A screening kit for paroxysmal supraventricular tachycardia contains a reagent for detecting a human CACNA1B gene c. 1700A>G mutation site at base No. 1700 in a coding region of CACNA1B gene from A to G.

Abstract: A screening kit for paroxysmal supraventricular tachycardia contains a reagent for detecting a human CACNA1B gene c. 1700A>G mutation site at base No. 1700 in a coding region of CACNA1B gene from A to G.

Abstract: The present disclosure discloses a use of a ZNF124 gene in early screening or auxiliary diagnosis of retinitis pigmentosa disease. The present disclosure also discloses a use of a detection reagent for detecting ZNF124 gene mutation in preparation of a reagent or a kit for early screening or auxiliary diagnosis of the retinitis pigmentosa disease. Research of the present disclosure finds that the mutation of the ZNF124 gene is related to the retinitis pigmentosa disease, early screening or auxiliary diagnosis can be performed on the retinitis pigmentosa disease by detecting the mutation of the ZNF124 gene.

Abstract: The present application provides a switching power supply and a magnetic resonance imaging system. The switching power supply is used for supplying power to a radio frequency coil control device, wherein the radio frequency coil control device is used for controlling a flow direction of radio frequency power output by a radio frequency amplifier of the magnetic resonance imaging system. Moreover, the switching power supply comprises a first power unit, a second power unit, and an air-cored transformer, the second power unit and the first power unit being electrically coupled through the air-cored transformer, wherein the switching power supply is configured to operate at a preset frequency, and frequency multiplication of the preset frequency is beyond a reception bandwidth of the magnetic resonance imaging system.

Abstract: Provided is a construction method for an animal model for retinitis pigmentosa diseases and the application thereof, which relate to the technical field of medical engineering. According to the construction method for the animal model for retinitis pigmentosa diseases, by knocking out Hkdc1 gene sequences on genomes of target animals, the animal model for retinitis pigmentosa diseases is obtained. The animal model presents typical characteristics of retinitis pigmentosa, such as retina function damage and gradual apoptosis of photoreceptor cells. The animal model can be applied to research of retinitis pigmentosa diseases and for to screening medicine for the treatment of retinitis pigmentosa diseases.

Abstract: The present application provides a switching power supply and a magnetic resonance imaging system. The switching power supply is used for supplying power to a radio frequency coil control device, wherein the radio frequency coil control device is used for controlling a flow direction of radio frequency power output by a radio frequency amplifier of the magnetic resonance imaging system. Moreover, the switching power supply comprises a first power unit, a second power unit, and an air-cored transformer, the second power unit and the first power unit being electrically coupled through the air-cored transformer, wherein the switching power supply is configured to operate at a preset frequency, and frequency multiplication of the preset frequency is beyond a reception bandwidth of the magnetic resonance imaging system.

Abstract: Methods of detecting and treating diseases and pathological conditions of the eye are disclosed. In particular a genetic variant of the HtrA1 gene is correlated to age related macular degeneration (AMD). In addition, biologically active agents capable of inhibiting HtrA1 activity are provided, and methods of treating diseases and pathological conditions of the eye are additionally disclosed.

Abstract: Ocular diseases affecting the macula or the vasculature of the eye affect a wide variety of individuals. In particular, Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in the developed world and has a significant genetic predisposition. Methods of analyzing one or more mutations in the HtrA1 gene in order to identify individuals with a presusceptability to development of an ocular disease and a pathologic condition of the eye and diagnose those currently suffering from an ocular disease or a pathologic condition of the eye are provided. The methods of the present invention may further include analysis of the CFH gene in order to identify individuals with a presusceptability to development of an ocular disease and a pathologic condition of the eye and diagnose those currently suffering from an ocular disease or a pathologic condition of the eye. Compositions and methods for treating ocular disease and pathologic conditions of the eye are also provided.

Abstract: Disclosed herein are compositions and methods for the identification of a subject at risk for developing type 2 diabetes. Also disclosed is a therapeutic target for the prevention and treatment of type 2 diabetes.