Patents by Inventor Zhenglin YAO

Zhenglin YAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220315532
    Abstract: The present invention relates to methods for preparing 5-fluoro-4-(7?-fluoro-2?-methylspiro[cyclopentane-1,3?-indol]-5?-yl)-N-(5-(1-methylpiperidin-4-yl)pyridin-2-yl)pyrimidin-2-amine and a salt and an intermediate thereof The methods provided herein have improved the existing synthesis methods, simplified the preparation process and increased the yield and purity, and can well meet the requirement of large-scale industrial manufacture.
    Type: Application
    Filed: June 22, 2020
    Publication date: October 6, 2022
    Inventors: Yining ZHANG, Lei YIN, Zhenglin YAO
  • Publication number: 20220168302
    Abstract: The present invention relates to the fumarate, maleate, adipate, and succinate of a compound 5-fluoro-4-(7?-fluoro-2?-methylspiro[cyclopentane-1,3?-indol]-5?-yl)-N-(5-(1-methylpiperidin-4-yl)pyridin-2-yl)pyrimidine-2-amine, multiple crystal forms of the salts and preparation method and use thereof. It has been confirmed that the above salts or crystal forms thereof can better replace 5-fluoro-4-(7?-fluoro-2?-methylspiro[cyclopentane-1,3?-indol]-5?-yl)-N-(5-(1-methylpiperidin-4-yl)pyridin-2-yl)pyrimidine-2-amine, so as to overcome its shortcomings in solubility, high risk of food effects, stability and the like, and meanwhile, the above salts or crystal forms thereof have a relatively low hygroscopicity, and high application value.
    Type: Application
    Filed: June 22, 2020
    Publication date: June 2, 2022
    Inventors: Lei YIN, Zhenglin YAO