Patents by Inventor Zhengming Chen

Zhengming Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel 1-Heteroaryl-3-Azabicyclo[3.1.0]Hexanes Methods For Their Preparation And Their Use As Medicaments
    Publication number: 20140303207
    Abstract: The invention provides novel 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including but not limited to depression and anxiety.
    Type: Application
    Filed: April 3, 2013
    Publication date: October 9, 2014
    Applicant: NEUROVANCE, Inc.
    Inventors: Phil SKOLNICK, Zhengming Chen
  • Stereoselective synthesis of metyrosine
    Patent number: 8841486
    Abstract: Provided herein are compositions including diastereomers in substantially diastereomerically pure form and enantiomers in substantially enantiomerically pure form, and processes for preparing them and converting them to metyrosine.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: September 23, 2014
    Assignee: Aton Pharma
    Inventors: Kevin John Halloran, Alex Comely, Zhengming Chen, Shyam Krishnan
  • Treatment of restenosis and stenosis with dasatinib
    Patent number: 8815260
    Abstract: A method for treating or inhibiting artery obstructive disease, such as restenosis after angioplasty and stenting procedures and stenosis after coronary artery bypass surgery, in a subject by administering to the subject a therapeutically effective amount of dasatinib or a derivative thereof. Also provided are drug-eluting medical devices, including stents, having a therapeutically effective amount of dasatinib.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: August 26, 2014
    Assignees: University of South Florida, H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Jie Wu, Zhengming Chen, Kapil N. Bhalla
  • Benzenesulfonamide compounds and their use as blockers of calcium channels
    Patent number: 8791264
    Abstract: The invention relates to piperidinyl and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3, Z and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: July 29, 2014
    Assignee: Purdue Pharma L.P.
    Inventors: Zhengming Chen, Bin Shao, Jiangchao Yao, Xiaoming Zhou
  • Fused and Spirocycle Compounds and the Use Thereof
    Publication number: 20140045875
    Abstract: The invention relates to fused and spirocycle compounds of Formula (I), or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R1, R2, Q1-Q3, and Z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
    Type: Application
    Filed: July 29, 2013
    Publication date: February 13, 2014
    Applicant: Purdue Pharma L.P.
    Inventors: Zhengming CHEN, Laykea Tafesse, Jiangchao Yao, Khondaker Islam
  • Novel 1-Aryl-3-Azabicyclo[3.1.0]Hexanes: Preparation And Use To Treat Neuropsychiatric Disorders
    Publication number: 20130345439
    Abstract: The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including depression and anxiety.
    Type: Application
    Filed: May 5, 2013
    Publication date: December 26, 2013
    Inventors: Phil SKOLNICK, Anthony Basile, Zhengming Chen, Joseph W. Epstein
  • Fused and spirocycle compounds and the use thereof
    Patent number: 8546417
    Abstract: The invention relates to fused and spirocycle compounds of Formula I: or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R1, R2, Q1-Q3, and Z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: October 1, 2013
    Assignee: Purdue Pharma L.P.
    Inventors: Zhengming Chen, Laykea Tafesse
  • 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
    Patent number: 8461196
    Abstract: The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including depression and anxiety.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: June 11, 2013
    Inventors: Phil Skolnick, Anthony Basile, Zhengming Chen, Joseph W. Epstein
  • Fused and Spirocycle Compounds and the Use Thereof
    Publication number: 20120309778
    Abstract: The invention relates to fused and spirocycle compounds of Formula (I), or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R1, R2, Q1-Q3, and Z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
    Type: Application
    Filed: June 1, 2012
    Publication date: December 6, 2012
    Applicant: Purdue Pharma L.P.
    Inventors: Zhengming CHEN, Laykea TAFESSE, Jiangchao YAO, Khondaker ISLAM
  • Novel 1-aryl-3-Azabicyclo[3.1.0]Hexanes: Preparation And Use To Treat Neuropsychiatric Disorders
    Publication number: 20120302619
    Abstract: The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including depression and anxiety.
    Type: Application
    Filed: February 3, 2012
    Publication date: November 29, 2012
    Inventors: Phil SKOLNICK, Anthony Basile, Zhengming Chen, Joseph W. Epstein
  • Nociceptin analogs
    Patent number: 8252815
    Abstract: A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: August 28, 2012
    Assignee: Purdue Pharma L.P.
    Inventors: Qun Sun, R. Richard Goehring, Donald Kyle, Zhengming Chen, Sam Victory, John Whitehead
  • Benzenesulfonamide compounds and their use
    Patent number: 8247442
    Abstract: The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula I and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3 and Z are defined as set forth in the specification. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: August 21, 2012
    Assignee: Purdue Pharma L.P.
    Inventors: Zhengming Chen, Khondaker Islam, Bin Shao, Jiangchao Yao, Donald J. Kyle
  • Fused and spirocycle compounds and the use thereof
    Patent number: 8193208
    Abstract: The invention relates to fused and spirocycle compounds of Formula I: or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R1, R2, Q1-Q3, and Z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: June 5, 2012
    Assignee: Purdue Pharma L.P.
    Inventors: Zhengming Chen, Laykea Tafesse, Jiangchao Yao, Khondaker Islam
  • NOCICEPTIN ANALOGS
    Publication number: 20120095049
    Abstract: A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
    Type: Application
    Filed: March 18, 2011
    Publication date: April 19, 2012
    Applicant: Purdue Pharma L.P.
    Inventors: Qun SUN, R. Richard Goehring, Donald Kyle, Zhengming Chen, Sam Victory, John Whitehead
  • Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
    Patent number: 8138377
    Abstract: The invention provides novel arylbicyclo[3.1.0]hexylamines, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including but not limited to depression and anxiety.
    Type: Grant
    Filed: November 6, 2007
    Date of Patent: March 20, 2012
    Assignee: DOV Pharmaceutical, Inc.
    Inventors: Phil Skolnick, Zhengming Chen, Ji Yang
  • Therapeutic agents useful for treating pain
    Patent number: 8026254
    Abstract: 4-Tetrazolyl-4-phenylpiperidine Compounds, compositions comprising an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound, methods for treating or preventing pain or diarrhea in an animal comprising administering to an animal in need thereof an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound and methods for stimulating opioid-receptor function in a cell comprising contacting a cell capable of expressing an opioid receptor with an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound are disclosed.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: September 27, 2011
    Assignee: Purdue Pharma, L.P.
    Inventor: Zhengming Chen
  • Nociceptin analogs
    Patent number: 7939670
    Abstract: A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: May 10, 2011
    Assignee: Purdue Pharma L.P.
    Inventors: Qun Sun, R. Richard Goehring, Donald Kyle, Zhengming Chen, Sam Victory, John Whitehead
  • STEREOSELECTIVE SYNTHESIS OF METYROSINE
    Publication number: 20110104765
    Abstract: Provided herein are compositions including diastereomers in substantially diastereomerically pure form and enantiomers in substantially enantiomerically pure form, and processes for preparing them and converting them to metyrosine.
    Type: Application
    Filed: October 29, 2010
    Publication date: May 5, 2011
    Inventors: Kevin John HALLORAN, Alex COMELY, Zhengming CHEN, Shyam KRISHNAN
  • Therapeutic agents useful for treating pain
    Patent number: 7687518
    Abstract: 4-Tetrazolyl-4-phenylpiperidine Compounds, compositions comprising an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound, methods for treating or preventing pain or diarrhea in an animal comprising administering to an animal in need thereof an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound and methods for stimulating opioid-receptor function in a cell comprising contacting a cell capable of expressing an opioid receptor with an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound are disclosed.
    Type: Grant
    Filed: March 28, 2007
    Date of Patent: March 30, 2010
    Assignee: Purdue Pharma L.P.
    Inventor: Zhengming Chen
  • THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN
    Publication number: 20100069437
    Abstract: 4-Tetrazolyl-4-phenylpiperidine Compounds, compositions comprising an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound, methods for treating or preventing pain or diarrhea in an animal comprising administering to an animal in need thereof an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound and methods for stimulating opioid-receptor function in a cell comprising contacting a cell capable of expressing an opioid receptor with an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound are disclosed.
    Type: Application
    Filed: November 10, 2009
    Publication date: March 18, 2010
    Applicant: Purdue Pharma L.P.
    Inventor: Zhengming Chen