Patents by Inventor Zhengne Wang

Zhengne Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods of treating cancer harboring PIKC3A mutations
    Patent number: 10221459
    Abstract: A method of treating cancer cells having mutated PIK3CA gene or protein of a subject in need thereof includes administering to the subject a therapeutically effective amount of an inhibitor of one or more enzymes of the glutamine metabolism pathway.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: March 5, 2019
    Assignee: Case Western Reserve University
    Inventors: Zhengne Wang, Yujun Hao
  • COMPOSITIONS AND METHODS OF TREATING CANCER HARBORING PIKC3A MUTATIONS
    Publication number: 20160010158
    Abstract: A method of treating cancer cells having mutated PIK3CA gene or protein of a subject in need thereof includes administering to the subject a therapeutically effective amount of an inhibitor of one or more enzymes of the glutamine metabolism pathway.
    Type: Application
    Filed: May 13, 2015
    Publication date: January 14, 2016
    Inventors: Zhengne Wang, Yujun Hao
  • TARGETED GENE MODIFICATION USING HYBRID RECOMBINANT ADENO-ASSOCIATED VIRUS
    Publication number: 20140359799
    Abstract: An in vitro method of producing a mouse cell having a genetic modification at a preselected genomic target locus includes transducing into the mouse cell an effective amount of a hybrid recombinant adeno-associated virus (AAV) vector that includes an AAV targeting construct of a first serotype packaged with a variant AAV capsid protein different than a capsid protein of the first serotype.
    Type: Application
    Filed: December 24, 2012
    Publication date: December 4, 2014
    Inventors: Zhengne Wang, Xiujing Feng, Peng Zhang, Yujun Hao
  • COMPOSITIONS AND METHODS FOR INHIBITING THE ACTIVITY OF P110a MUTANT PROTEINS
    Publication number: 20140005119
    Abstract: A method of inhibiting the activity, signaling, and/or function of a p110? mutant protein in a cancer cell expressing the p110? mutant protein includes administering to the cancer cell an amount of a therapeutic agent effective to inhibit binding of the p110? mutant protein to IRS1 in the cell.
    Type: Application
    Filed: June 28, 2013
    Publication date: January 2, 2014
    Inventors: Zhengne Wang, Yujun Hao, Chao Wang, Weiping Zheng
  • METHOD OF CHARACTERIZING ENDOGENOUS POLYNUCLEOTIDE-POLYPEPTIDE INTERACTIONS
    Publication number: 20090305272
    Abstract: A method for characterizing an endogenous polypeptide includes introducing epitope tag-encoding polynucleotide into an endogenous locus of a somatic cell by homogenous recombination mediated knock-in so that an epitope tagged endogenous polypeptide is expressed by the cell, and characterizing the epitope tagged endogenous polypeptide using an immunoassay.
    Type: Application
    Filed: January 5, 2009
    Publication date: December 10, 2009
    Inventors: Zhengne Wang, Xiaodong Zhang