Patents by Inventor Zhengping Zhuang
Zhengping Zhuang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230054318Abstract: Disclosed herein is a personalized tumor vaccine comprising attenuated cancer cells and a method of using said personalized tumor vaccine to treat cancer.Type: ApplicationFiled: December 11, 2020Publication date: February 23, 2023Inventors: Zhengping Zhuang, Rogelio Medina, Herui Wang, Jan Zenka, Karel Pacak, Winson Ho
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Publication number: 20220349787Abstract: Disclosed is plate or film for collecting and analyzing a sample. The plate or film includes a surface and a plurality of slices from the sample immobilized on the surface. Further, the plurality of slices are cut from the sample with equal thickness, and the plurality of slices are placed on the surface of the plate or film following their cutting order.Type: ApplicationFiled: March 19, 2020Publication date: November 3, 2022Inventors: Zhengping Zhuang, Anthony Cappadona, Young Wan Moon
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Patent number: 11351185Abstract: A pharmaceutical composition containing any one or more of 4?-O-isolvalerylspiramycin I, II and III counters tumorigenesis and reduces or prevents metastasis by inhibiting selenoprotein H to trigger genomic instability and cell-cycle arrest in cancer cells.Type: GrantFiled: March 11, 2020Date of Patent: June 7, 2022Assignees: ASCLEA CORPORATION, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTHInventors: Enhong Jiang, Zhengping Zhuang, Jing Cui
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Publication number: 20220009980Abstract: Methods of decreasing cell viability of cancer cells, increasing apoptosis of cancer cells, and treating cancer in a mammal with cancer are provided. The methods include administering (i) a polypeptide comprising an amino acid sequence with at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 1, (ii) a nucleic acid molecule comprising a nucleic acid sequence encoding the polypeptide, (iii) a vector comprising the nucleic acid molecule, (iv) a recombinant cell comprising any one of (i)-(iii), and/or (v) a composition comprising any one of (i)-(iv).Type: ApplicationFiled: November 13, 2019Publication date: January 13, 2022Applicant: The United States of America,as represented by the Secretary,Department of Health and Human ServicesInventors: Zhengping Zhuang, Emeline Tabouret, Herui Wang, Harish Pant, Niranjana D. Amin
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Publication number: 20210346430Abstract: Disclosed is a method for treating glioblastoma or other brain tumors. The method includes steps of preparing cells comprising a chimeric antigen receptor (CAR) molecule and administering to a mammal in need thereof an effective amount of the prepared cells. Also disclosed is that the CAR molecule contains an antigen binding domain that binds to the tumor antigen associated with the glioblastoma or other brain tumors, and the tumor antigen is carbonic anhydrase IX.Type: ApplicationFiled: August 23, 2019Publication date: November 11, 2021Inventors: Zhengping Zhuang, Kaiyong Yang, Jing Cui, Qi Zhang
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Publication number: 20210283159Abstract: A pharmaceutical composition containing any one or more of 4?-O-isolvalerylspiramycin I, II and III counters tumorigenesis and reduces or prevents metastasis by inhibiting selenoprotein H to trigger genomic instability and cell-cycle arrest in cancer cells.Type: ApplicationFiled: March 11, 2020Publication date: September 16, 2021Applicants: ASCLEA CORPORATION, THE UNITED STATES OF AMERICA, as represented by the Secretary, Dept, of Health and Human Svcs.Inventors: Enhong JIANG, Zhengping ZHUANG, Jing CUI
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Publication number: 20210052644Abstract: Disclosed is a method for treating glioblastoma or other brain tumors. The method includes steps of preparing cells comprising a chimeric antigen receptor (CAR) molecule and administering to a mammal in need thereof an effective amount of the prepared cells. Also disclosed is that the CAR molecule contains an antigen binding domain that binds to the tumor antigen associated with the glioblastoma or other brain tumors, and the tumor antigen is carbonic anhydrase IX.Type: ApplicationFiled: August 23, 2019Publication date: February 25, 2021Inventors: Zhengping Zhuang, Kaiyong Yang, Jing Cui, Qi Zhang
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Publication number: 20200069680Abstract: The present invention provides a method of treating a subject afflicted with cancer comprising administering to the subject an effective amount of a PP2A inhibitor.Type: ApplicationFiled: December 8, 2017Publication date: March 5, 2020Inventors: John S. Kovach, Zhengping Zhuang, Sze Chun Winson Ho, Herui Wang, Rongze Lu
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Publication number: 20170136008Abstract: A method of treating ovarian cancer in a subject afflicted therewith comprising administering to the subject an effective amount of an anti-cancer agent and an effective amount of a compound having the structure:Type: ApplicationFiled: June 19, 2015Publication date: May 18, 2017Applicants: Lixte Biotechnology, Inc., The United States of America, as Represented by th e Secretary, Department of Health & Human ServiceInventors: John S. Kovach, Zhengping Zhuang, Ki-eun Chang, Matthew Hall, Michael M. Gottesman
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Publication number: 20140235649Abstract: A method of treating a mammalian subject afflicted with a disease characterized by a loss of protein function caused by a genetic abnormality associated with the disease comprising administering to the subject a therapeutically effective amount of a protein phosphatase 2A inhibitor or a histone deacetylase inhibitor.Type: ApplicationFiled: May 24, 2012Publication date: August 21, 2014Applicant: LIXTE BIOTECHNOLOGY, INC.Inventors: John S. Kovach, Zhengping Zhuang, Jie Lu, Chunzhang Yang, Russell Lonser
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Publication number: 20100029683Abstract: Disclosed herein are methods of inhibiting proliferation of a cancer cell or inducing apoptosis of a cancer cell, which does not overexpress N—CoR. Also disclosed herein are methods of inhibiting proliferation or inducing apoptosis of a cancer cell that overexpresses TCTP and methods for determining whether a compound is effective in inducing cell death.Type: ApplicationFiled: July 17, 2009Publication date: February 4, 2010Inventors: John S. Kovach, Zhengping Zhuang, Jie Lu
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Publication number: 20090035292Abstract: Disclosed herein are methods of treating neuroblastomas and medulloblastomas in a subject comprising administering to the subject a phosphatase ligand in an amount effective to treat the subject. Also disclosed herein are method of treating neuroblastomas and medulloblastomas in a subject comprising administering to the subject a histone deacteylase ligand in an amount effective to treat the subject.Type: ApplicationFiled: August 1, 2008Publication date: February 5, 2009Inventors: John S. Kovach, Zhengping Zhuang
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Publication number: 20090018142Abstract: This invention provides a method of treating a patient suffering from a tumor overexpressing N—CoR comprising administering to the patient a phosphatase ligand, alone or in combination with a retinoid receptor ligand, a histone deacetylase ligand, or both, in amounts effective to treat the patient. This invention also provides a method of inhibiting tumor growth in a patient suffering from a tumor overexpressing N—CoR. This invention further provides a method of identifying a compound or a mixture of compounds capable of inducing differentiation of cells of a tumor overexpressing N—CoR. This invention still further provides a method of determining the likelihood of successfully treating a subject suffering from a tumor overexpressing N—CoR. This invention also provides a method of assessing the likelihood that a patient is suffering from a tumor overexpressing N—CoR.Type: ApplicationFiled: February 6, 2007Publication date: January 15, 2009Inventors: Zhengping Zhuang, Edward H. Oldfield, Deric M. Park, Irina Lubensky, Jie Li, John S. Kovach
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Publication number: 20080214569Abstract: This invention provides a method of treating a patient suffering from a tumor overexpressing N—CoR comprising administering to the patient a phosphatase ligand, alone or in combination with a retinoid receptor ligand, a histone deacetylase ligand, or both, in amounts effective to treat the patient. This invention also provides a method of inhibiting tumor growth in a patient suffering from a tumor overexpressing N—CoR. This invention further provides a method of identifying a compound or a mixture of compounds capable of inducing differentiation of cells of a tumor overexpressing N—CoR. This invention still further provides a method of determining the likelihood of successfully treating a subject suffering from a tumor overexpressing N—CoR. This invention also provides a method of assessing the likelihood that a patient is suffering from a tumor overexpressing N—CoR.Type: ApplicationFiled: February 8, 2007Publication date: September 4, 2008Inventors: Zhengping Zhuang, Edward H. Oldfield, Deric M. Park, Irina Lubensky, Jie Li, John S. Kovach
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Patent number: 7358347Abstract: The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated mutations in the corresponding gene have been identified in individuals suffering from multiple endocrine neoplasia type 1. The identification of this marker for multiple endocrine neoplasia type 1 has diagnostic uses as well as for gene therapy.Type: GrantFiled: March 4, 1998Date of Patent: April 15, 2008Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Settara Chandrasekharappa, Siradanahalli Guru, Pachiappan Manickam, Francis S. Collins, Michael R. Emmert-Buck, Larisa V. Debelenko, Irina A. Lubensky, Lance A. Liotta, Sunita K. Agarwal, Allen M. Spiegel, A. Lee Burns, Stephen J. Marx, Zhengping Zhuang
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Patent number: 6569639Abstract: A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.Type: GrantFiled: January 18, 2001Date of Patent: May 27, 2003Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Lance A. Liotta, Michael E. Buck, Rhonda Ann Weiss, Zhengping Zhuang, Robert F. Bonner
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Publication number: 20010031481Abstract: A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.Type: ApplicationFiled: January 18, 2001Publication date: October 18, 2001Inventors: Lance A. Liotta, Michael E. Buck, Rhonda Ann Weiss, Zhengping Zhuang, Robert F. Bonner
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Patent number: 6204030Abstract: A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.Type: GrantFiled: September 2, 1999Date of Patent: March 20, 2001Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Lance A. Liotta, Michael E. Buck, Rhonda Ann Weiss, Zhengping Zhuang, Robert F. Bonner
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Patent number: 6010888Abstract: A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.Type: GrantFiled: September 8, 1997Date of Patent: January 4, 2000Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Lance A. Liotta, Michael E. Buck, Rhonda Ann Weiss, Zhengping Zhuang, Robert F. Bonner
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Patent number: 5843644Abstract: A method of direct extraction of cellular material from a tissue sample which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extracted zone(s) of cells is subjected to analysis. The overall process of identifying, extracting, transporting, and analyzing the extracted zones(s) of cells can be fully automated.Type: GrantFiled: March 1, 1994Date of Patent: December 1, 1998Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Lance A. Liotta, Zhengping Zhuang, Michael R. Buck, William G. Stetler-Stevenson, Irina A. Lubensky, Mark J. Roth