Abstract: The present disclosure discloses a blended ternary positive-electrode material, a preparation method thereof and a lithium ion battery, and relates to the field of lithium battery technologies. A temperature-sensitive precursor type material is taken as a raw material, a large-particle precursor, a small-particle precursor and lithium sources are presintered to obtain a first presintered material and a second presintered material, presintered materials and binders are then mixed, compacted and punctured to obtain a first to-be-sintered material block and a second to-be-sintered material block, the first to-be-sintered material block and the second to-be-sintered material block are loaded into a sagger together for primary sintering, and using a periphery-center regional mode or an upper-lower-layer distribution mode, the first presintered material is distributed at a periphery or an upper layer, and the second presintered material is distributed at a center or a lower layer.

Abstract: The invention provides a compound of formula I, formula II, or formula III: or a salt thereof, wherein R1-R10 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as HIV-1 CA-targeting molecules and as antiviral agents.

Abstract: Provided are low-residual-alkali high-nickel ternary positive-electrode material, preparation method and application thereof. The preparation method of a low-residual-alkali high-nickel ternary positive-electrode material includes: presintering a nickel-containing precursor and a lithium salt to obtain a presintered material, and performing primary high-temperature sintering on the presintered material and a dopant, wherein the presintering is controlled to be performed under a micro-negative pressure condition, such that water of the lithium salt and carbon dioxide generated by a primary reaction of the precursor and the lithium salt can be fully discharged.

Abstract: A multi-layer composite functional separator for lithium ion battery includes four layers. Layer A is a base separator. Layer B is a porous structural layer composed of insulating inorganic compounds or high temperature resistant polymers. Layer C is a porous layer composed of polymer microspheres with temperature-induced expansion characteristics. Layer D is a thermoplastic resin with a melting point of 80-110° C. and a crystallinity of <50%. Layer B, Layer C and Layer D are sequentially attached on either or both sides of Layer A. Compared with the existing lithium-ion battery separator, the multi-Layer Composite functional separator has excellent heat resistance. The thermal shrinkage rate is less than 1% when heated for less than one hour at 200° C. Inclusion of organic polymer microspheres produces thermal closure of the batteries, which improves the safety of the batteries.

Abstract: The invention provides a compound of formula I, formula II, or formula III: or a salt thereof, wherein R1-R10 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as HIV-1 CA-targeting molecules and as antiviral agents.

Abstract: The present invention provides novel compounds and methods for treating, preventing or inhibiting hepatitis B virus (HBV).

Abstract: The invention provides a compound of formula (I), (II) or (III): wherein R1, R2, R3, R4 and R5 have any of the values described in the specification, as well as compositions comprising a compound of formula (I), (II) or (III). The compounds and compositions are useful as chemotherapeutic sensitizing agents.

Abstract: A multi-layer composite functional separator for lithium ion battery includes four layers. Layer A is a base separator. Layer B is a porous structural layer composed of insulating inorganic compounds or high temperature resistant polymers. Layer C is a porous layer composed of polymer microspheres with temperature-induced expansion characteristics. Layer D is a thermoplastic resin with a melting point of 80-110° C. and a crystallinity of <50%. Layer B, Layer C and Layer D are sequentially attached on either or both sides of Layer A. Compared with the existing lithium-ion battery separator, the multi-Layer Composite functional separator has excellent heat resistance. The thermal shrinkage rate is less than 1% when heated for less than one hour at 200° C. Inclusion of organic polymer microspheres produces thermal closure of the batteries, which improves the safety of the batteries.

Abstract: The invention provides a compound of formula (I), (II) or (III): wherein R1, R2, R3, R4 and R5 have any of the values described in the specification, as well as compositions comprising a compound of formula (I), (II) or (III). The compounds and compositions are useful as chemotherapeutic sensitizing agents.

Abstract: The present invention provides novel compounds and methods for treating, preventing or inhibiting hepatitis B virus (HBV).

Abstract: Various embodiments described herein are directed to compounds of formula (I), (II), (III) or (IV) for use as potent inhibitors of HIV integrase and for treatment of patients afflicted with AIDS. A major challenge of human immunodeficiency virus (HIV) chemotherapy continues to be the inevitable selection of resistance by the virus towards known drug regimens. Treating resistant HIV strains calls for novel antivirals with unique structural cores. Some embodiments are directed to compounds featuring a 3-hydroxypyrimidine-2,4-dione-5-carboxamide core that consistently confers low nanomolar potencies against HIV-1 in cell culture. Biochemical testing and molecular modeling results corroborate an antiviral mechanism of action of inhibiting integrase strand transfer (INST). Preliminary testing against raltegravir-resistant HIVs showed marginal cross resistance, suggesting that the chemotypes of the various embodiments described herein could fit an inhibitory profile of second generation INSTIs.

Abstract: Various embodiments described herein are directed to compounds of formula (I), (II), (III) or (IV) for use as potent inhibitors of HIV integrase and for treatment of patients afflicted with AIDS. A major challenge of human immunodeficiency virus (HIV) chemotherapy continues to be the inevitable selection of resistance by the virus towards known drug regimens. Treating resistant HIV strains calls for novel antivirals with unique structural cores. Some embodiments are directed to compounds featuring a 3-hydroxypyrimidine-2,4-dione-5-carboxamide core that consistently confers low nanomolar potencies against HIV-1 in cell culture. Biochemical testing and molecular modeling results corroborate an antiviral mechanism of action of inhibiting integrase strand transfer (INST). Preliminary testing against raltegravir-resistant HIVs showed marginal cross resistance, suggesting that the chemotypes of the various embodiments described herein could fit an inhibitory profile of second generation INSTIs.