Patents by Inventor Zhengrong SHUAI

Zhengrong SHUAI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODIES TO CD3 AND BCMA, AND BISPECIFIC BINDING PROTEINS MADE THEREFROM
    Publication number: 20230002489
    Abstract: High-affinity antibodies recognizing CD3 and B Cell Maturation Factor protein (BCMA) are disclosed. Binding sites from humanized anti-CD3 and anti-BCMA antibodies are incorporated into a Fabs-in-Tandem Immunoglobulin format without significant loss of binding affinity, and the resultant bispecific, multivalent binding proteins are able to bind to both CD3 and BCMA simultaneously. Such antibodies, antigen-binding portions thereof, and bispecific FIT-Ig binding proteins are useful for treating cancer.
    Type: Application
    Filed: November 26, 2020
    Publication date: January 5, 2023
    Inventors: Chengbin WU, Danqing WU, Lini HUANG, Amin ZHANG, Zhengrong SHUAI, Rui ZHANG, Shiyong GONG, Xuan WU
  • Anti-PD-1 antibodies and uses thereof
    Patent number: 10973915
    Abstract: Anti-PD-1 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancers and autoimmune diseases.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: April 13, 2021
    Assignee: SHANGHAI YUNYI HEALTHCARE AND TECHNOLOGY CO., LTD.
    Inventors: Lile Liu, Xinxiu Yang, Haishan Luo, Hu Liu, Zhengrong Shuai, Jian Wang, Qin Zhong, Qing Duan, Hongzhuan Gu, Tatchi Teddy Yang
  • Anti-PD-L1 antibodies and uses thereof
    Patent number: 10889648
    Abstract: Provided herein are anti-PD-L1 antibodies and antigen-binding fragments thereof. Also provided are nucleic acids encoding the antibodies, compositions containing the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer, infectious diseases and autoimmune diseases.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: January 12, 2021
    Assignee: JIANGSU HYAMAB PHARMACEUTICAL CO., LTD.
    Inventors: Lile Liu, Xinxiu Yang, Haishan Luo, Zhengrong Shuai, Hu Liu, Shaoping Hu, Xiaolan Sun, Hongzhuan Gu, Qing Duan, Tatchi Teddy Yang
  • ANTI-PD-L1 ANTIBODIES AND USES THEREOF
    Publication number: 20190010233
    Abstract: Provided herein are anti-PD-L1 antibodies and antigen-binding fragments thereof. Also provided are nucleic acids encoding the antibodies, compositions containing the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancer, infectious diseases and autoimmune diseases.
    Type: Application
    Filed: December 27, 2016
    Publication date: January 10, 2019
    Inventors: Lile LIU, Xinxiu YANG, Haishan LUO, Zhengrong SHUAI, Hu LIU, Shaoping HU, Xiaolan SUN, Hongzhuan GU, Qing DUAN, Tatchi Teddy YANG
  • ANTI-PD-1 ANTIBODIES AND USES THEREOF
    Publication number: 20180214548
    Abstract: Anti-PD-1 antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases such as cancers and autoimmune diseases.
    Type: Application
    Filed: July 27, 2016
    Publication date: August 2, 2018
    Inventors: Lile LIU, Xinxiu YANG, Haishan LUO, Hu LIU, Zhengrong SHUAI, Jian WANG, Qin ZHONG, Qing DUAN, Hongzhuan GU, Tatchi Teddy YANG