Abstract: The present disclosure relates to a flexible electrode and a manufacturing method therefor. Provided is a flexible electrode, comprising at least one implantable and flexible electrode wire and a continuous limiting layer. Each electrode wire comprises: a wire, the wire being located between a first insulating layer and a second insulating layer of the flexible electrode, and an electrode site, the electrode site being in contact with the biological tissue after implantation of the electrode wire, being located on the first insulating layer, and being electrically coupled to the wire by means of a through hole in the first insulating layer. The limiting layer is located on the at least one electrode wire and is configured to be detachably adhered to the at least one electrode wire, so that the at least one electrode wire is kept in a fixed arrangement during the implantation process.

Abstract: The present disclosure relates to an interventional device for implanting an electrode into the brain via a blood vessel, the blood vessel having a blood vessel channel and a blood vessel wall, characterized in that the interventional device comprises: a first guide member, the distal end of which can move distally in the blood vessel channel and establish a first support point in the blood vessel channel; a second guide member, the distal end of which can pass through the first guide member to move distally in the blood vessel channel and establish a second support point in the blood vessel channel, so that the second guide member extends in an arc shape between the first support point and the second support point; and a puncture kit, the puncture kit being used to carry the electrode, and the distal end of the puncture kit being able to pass through the first guide member to move distally in the blood vessel channel and puncture the blood vessel wall in a target puncture area between the first support point

Abstract: The present disclosure relates to a flexible electrode for a brain and a method for manufacturing the same. Provided is a flexible electrode for the brain, which comprises a cortical attachment portion that can be implanted into the brain, and one or more deep implantation portions, the cortical attachment portion having a sheet-like structure capable of covering and being flattened to fit against at least a portion of a cerebral cortex after implantation, and the deep implantation portions being configured to be implanted into a deep region of the brain and bent relative to the cortical attachment portion after implantation, wherein the deep implantation portions and the cortical attachment portion each comprise one or more electrode sites, each of the electrode sites being electrically coupled to one of wires in the wire layer and being in contact with the brain after the flexible electrode is implanted into the brain.

Abstract: A flexible probe includes a probe body having a distal end and a proximal end, and comprises at least one flexible nanoelectronic thread having a distal end and a proximal end and a length therebetween, the nanoelectronic thread comprising at least one electrode positioned on a top surface of the nanoelectronic thread, and at least one nanoscale wire is partially encapsulated, having a first portion electrically connected to at least one of the electrodes and a second portion surrounded by a dielectric insulator, the probe further including at least one external trace electrically connected to the at least one nanoscale wire at the proximal end of the at least one nanoelectronic thread, the at least one external trace having a width larger than the width of the at least one nanoscale wire, and an interface connector near the proximal end of the probe body, electrically connected to the at least one electrode via the at least one nanoscale wire and the at least one external trace, wherein the at least one nano

Abstract: Devices and methods for performing frequency domain (FD) fluorescence lifetime spectroscopy are provided. The devices include a modulated light source, a focusing optical fiber, a detecting optical fiber, and a detector. The methods include focusing sinusoidal modulated incident light from a light source on a biological sample containing a protein, detecting a range of wavelengths of sinusoidal modulated fluorescent light emitted from the protein, determining a phase shift for the modulated fluorescent light, determining an amplitude modulation of the modulated fluorescent light, and determining a fluorescence lifetime of the protein.

Abstract: Devices and methods for performing frequency domain (FD) fluorescence lifetime spectroscopy are provided. The devices include a modulated light source, a focusing optical fiber, a detecting optical fiber, and a detector. The methods include focusing sinusoidal modulated incident light from a light source on a biological sample containing a protein, detecting a range of wavelengths of sinusoidal modulated fluorescent light emitted from the protein, determining a phase shift for the modulated fluorescent light, determining an amplitude modulation of the modulated fluorescent light, and determining a fluorescence lifetime of the protein.