Abstract: The present invention relates to a benzo seven-membered ring bifunctional compound and an application thereof, and in particular to a compound represented by formula (IV) and a pharmaceutically acceptable salt thereof. The compound can be used for preparing a drug for treating diseases related to an estrogen receptor protein degradation targeting chimera.

Abstract: Provided is an intelligent 3D printing method for a large 3D deep complex engineering geological model, including the steps of firstly, determining physical and mechanical parameters of the similar materials of the intact rock mass and the rock mass structure, and selecting a cementing agent; performing a small-scale 3D printing test at different material ratios and 3D printing parameters; determining the 3D printing similar material ratios and the 3D printing parameters; establishing a 3D digital model, planning printing paths, and determining pore diameters, number and combination form of the print heads; conveying the similar materials to the print heads; under the control of a 3D printing intelligent coupling control system, running each print head according to the planned and generated printing paths to complete printing; and finally, testing a printing effect of the model.

Abstract: A system for monitoring rotating equipment. The system includes a sensor device that acquires vibration data, acoustic emission data, temperature data, and magnetic flux data of the rotating equipment. The sensor device includes base, holding frame, first integrated circuit, housing, and power source. The first integrated circuit includes a plurality of sensors and a microcontroller configured to receive vibration data, acoustic emission data, temperature data, magnetic flux data from plurality of sensors and determine anomalies of the rotating equipment. The system further comprises an application server that receives vibration data and magnetic flux data, determines revolutions per minute (RPM) data for rotating equipment, and diagnose faults based on processed vibration data and RPM data. The application server further generates a set of features and corresponding feature values and analyzes them to diagnose faults, and predict remaining useful life of the rotating equipment.

Abstract: Disclosed in the present invention are a macrocyclic compound serving as a Weel inhibitor, and applications thereof in the preparation of drugs for treating Weel-related diseases. The present invention specifically relates to a compound represented by formula (II), an isomer thereof, and a pharmaceutically acceptable salt thereof.

Abstract: Provided is an intelligent 3D printing method for a large 3D deep complex engineering geological model, including the steps of firstly, determining physical and mechanical parameters of the similar materials of the intact rock mass and the rock mass structure, and selecting a cementing agent; performing a small-scale 3D printing test at different material ratios and 3D printing parameters; determining the 3D printing similar material ratios and the 3D printing parameters; establishing a 3D digital model, planning printing paths, and determining pore diameters, number and combination form of the print heads; conveying the similar materials to the print heads; under the control of a 3D printing intelligent coupling control system, running each print head according to the planned and generated printing paths to complete printing; and finally, testing a printing effect of the model.

Abstract: Disclosed is a crystal form of a compound of formula (I) and the use of the crystal form in the preparation of a drug for treating Wee1-related diseases.

Abstract: The present disclosure provides a method and a device for imaging diffracted waves based on azimuth-dip angle gathers and a storage medium, which relates to the technical field of seismic exploration, comprising firstly acquiring seismic data and generating target azimuth-dip angle gathers based on the seismic data, wherein the target azimuth-dip angle gathers are a set of all azimuth-dip angle gathers in which the Fresnel zones have been muted, and each of the azimuth-dip angle gathers represents a dip-angle gather corresponding to each azimuth angle; then detecting diffracted waves based on the target azimuth-dip angle gathers, and determining the type of the diffracted waves; and finally, imaging the diffracted waves based on the type of the diffracted waves to obtain a diffracted wave imaging result.

Abstract: A system for monitoring rotating equipment. The system includes a sensor device that acquires vibration data, acoustic emission data, temperature data, and magnetic flux data of the rotating equipment. The sensor device includes base, holding frame, first integrated circuit, housing, and power source. The first integrated circuit includes a plurality of sensors and a microcontroller configured to receive vibration data, acoustic emission data, temperature data, magnetic flux data from plurality of sensors and determine anomalies of the rotating equipment. The system further comprises an application server that receives vibration data and magnetic flux data, determines revolutions per minute (RPM) data for rotating equipment, and diagnose faults based on processed vibration data and RPM data. The application server further generates a set of features and corresponding feature values and analyzes them to diagnose faults, and predict remaining useful life of the rotating equipment.

Abstract: The present disclosure provides a method and a device for imaging diffracted waves based on azimuth-dip angle gathers and a storage medium, which relates to the technical field of seismic exploration, comprising firstly acquiring seismic data and generating target azimuth-dip angle gathers based on the seismic data, wherein the target azimuth-dip angle gathers are a set of all azimuth-dip angle gathers in which the Fresnel zones have been muted, and each of the azimuth-dip angle gathers represents a dip-angle gather corresponding to each azimuth angle; then detecting diffracted waves based on the target azimuth-dip angle gathers, and determining the type of the diffracted waves; and finally, imaging the diffracted waves based on the type of the diffracted waves to obtain a diffracted wave imaging result.

Abstract: A pyrimidopyrazolone derivative as a Wee1 inhibitor and use thereof in preparation of a medicament for treating Wee1-related diseases are described. In particular, the present invention relates to a compound of formula (I), an isomer or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides a 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one compound having an inhibitory effect on Wee1, and includes an application of the compound in treating various types of tumors.

Abstract: Disclosed in the present invention are a macrocyclic compound serving as a Weel inhibitor, and applications thereof in the preparation of drugs for treating Weel-related diseases. The present invention specifically relates to a compound represented by formula (II), an isomer thereof, and a pharmaceutically acceptable salt thereof.

Abstract: A large-scale three-dimensional physical model test system for a deep cavern group comprises a base, an anti-deformation prestressed loading frame assembly, a load applying assembly, a model sample preparation and transportation assembly and a multifunctional hydraulic loading system assembly. The anti-deformation prestressed loading frame assembly and the model sample preparation and transportation assembly are both arranged on the base. The load applying assembly is arranged on the anti-deformation prestressed loading frame assembly, and the load applying assembly is connected with the multifunctional hydraulic loading system assembly. A model sample is subjected to long-time load holding, dynamic disturbance and displacement control overload under multi-surface multi-point cooperative control through cooperation between the load applying assembly and the multifunctional hydraulic loading system assembly.

Abstract: The present invention relates to a tyrosine kinase inhibitor and a pharmaceutical composition comprising same.

Abstract: The present invention provides a 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one compound having an inhibitory effect on Wee1, and includes an application of the compound in treating various types of tumors.

Abstract: A large-scale three-dimensional physical model test system for a deep cavern group comprises a base, an anti-deformation prestressed loading frame assembly, a load applying assembly, a model sample preparation and transportation assembly and a multifunctional hydraulic loading system assembly. The anti-deformation prestressed loading frame assembly and the model sample preparation and transportation assembly are both arranged on the base. The load applying assembly is arranged on the anti-deformation prestressed loading frame assembly, and the load applying assembly is connected with the multifunctional hydraulic loading system assembly. A model sample is subjected to long-time load holding, dynamic disturbance and displacement control overload under multi-surface multi-point cooperative control through cooperation between the load applying assembly and the multifunctional hydraulic loading system assembly.

Abstract: The present invention relates to a tyrosine kinase inhibitor and a pharmaceutical composition comprising same.

Abstract: The present invention claims a nuclear reactor which can package the nuclear fuel and the coolant together in a spherical solid and transfer heat to the steam generator through the flow of spherical solid between the reactor vessel (1) and the steam generator (2) by two sets of mechanical transmission systems (4). The reactor is featured in high inherent safety, high outlet temperature parameter and full use of the nuclear fuel. It can be applied in many fields, such as power generation, hydrogen production, heating, liquefaction and gasification of coal and so on.

Abstract: A titanium based composite which includes a Ti(Al,O) base matrix, discrete ceramic particles, and an oxide layer on the surface of the composite. The discrete ceramic particles are integrally associated with the Ti(Al,O) base matrix and the oxide layer, so that at a temperature of above about 600° C., the composite is substantially resistant to oxidation and spallation.

Abstract: A titanium based composite which includes a Ti(Al,O) base matrix, discrete ceramic particles, and an oxide layer on the surface of the composite. The discrete ceramic particles are integrally associated with the Ti(Al,O) base matrix and the oxide layer, so that at a temperature of above about 600° C., the composite is substantially resistant to oxidation and spallation.