Abstract: The present disclosure provides a method and apparatus for simulating a physiological dynamic blood flow, a computer device and a storage medium. The method for simulating a physiological dynamic blood flow includes the following steps: acquiring related parameters of a cardio-aortic system in a complete cardiac cycle under a normal physiological state, and acquiring morphological and motion imaging data of the cardio-aortic system in the complete cardiac cycle; constructing a circulation dynamic loading function for cyclic dynamic contraction of a left ventricle; constructing a function between a left ventricular (LV) dynamic blood pressure and an LV dynamic volume; constructing a dynamic arterial blood flow volume function; constructing a cyclic opening and closing activation function of an aortic valve; and constructing a physiological dynamic blood flow model, and simulating the physiological dynamic blood flow according to the physiological dynamic blood flow model.