Patents by Inventor Zhengwu Shen

Zhengwu Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12234241
    Abstract: Provided is an imidazotriazine thiobenzamide derivative of formula (I), A preparation method for the imidazotriazine thiobenzamide derivative, and a use of the imidazotriazine thiobenzamide derivative or an isomer, a pharmaceutically-acceptable salt, or a prodrug thereof in the preparation of drugs for the treatment of cancer are also provided.
    Type: Grant
    Filed: April 12, 2024
    Date of Patent: February 25, 2025
    Assignee: Yunbaiyao Zhengwu Science and Technology (Shanghai) Co., Ltd.
    Inventors: Zhengwu Shen, Bin Deng, Yunxiang Fan, Yangli Shen, Xuejiang Chen, Yinshuang Wu, Xinyi Wang, Hongzhu Bian
  • Patent number: 12168659
    Abstract: A thioamide derivative of formula (I) and a preparation method thereof: An application of the thioamide derivative, or an isomer, a pharmaceutically-acceptable salt, or a prodrug molecule thereof in the preparation of a drug for the treatment of cancer is also provided. The thioamide derivative is a new compound with high antitumor activity, and can be used for antitumor therapy alone or in combination with other drugs.
    Type: Grant
    Filed: April 25, 2024
    Date of Patent: December 17, 2024
    Assignee: Yunbaiyao Zhengwu Science and Technology (Shanghai) Co., Ltd.
    Inventors: Zhengwu Shen, Bin Deng, Mengqi Zhang, Hongzhu Bian
  • Publication number: 20240327405
    Abstract: A thioamide derivative of formula (I) and a preparation method thereof: An application of the thioamide derivative, or an isomer, a pharmaceutically-acceptable salt, or a prodrug molecule thereof in the preparation of a drug for the treatment of cancer is also provided. The thioamide derivative is a new compound with high antitumor activity, and can be used for antitumor therapy alone or in combination with other drugs.
    Type: Application
    Filed: April 25, 2024
    Publication date: October 3, 2024
    Inventors: Zhengwu SHEN, Bin DENG, Mengqi ZHANG, Hongzhu BIAN
  • Publication number: 20240294535
    Abstract: Provided is an imidazotriazine thiobenzamide derivative of formula (I), A preparation method for the imidazotriazine thiobenzamide derivative, and a use of the imidazotriazine thiobenzamide derivative or an isomer, a pharmaceutically-acceptable salt, or a prodrug thereof in the preparation of drugs for the treatment of cancer are also provided.
    Type: Application
    Filed: April 12, 2024
    Publication date: September 5, 2024
    Inventors: Zhengwu SHEN, Bin DENG, Yunxiang FAN, Yangli SHEN, Xuejiang CHEN, Yinshuang WU, Xinyi WANG, Hongzhu BIAN
  • Patent number: 11787790
    Abstract: Disclosed are a benzimidazole derivative of formula (I), or an isomer, a pharmaceutically-acceptable salt, or a prodrug thereof, and a preparation thereof. An application of the benzimidazole derivative in the treatment of tumors is further provided.
    Type: Grant
    Filed: September 19, 2022
    Date of Patent: October 17, 2023
    Assignee: YUNBAIYAO ZHENGWU SCIENCE AND TECHNOLOGY (SHANGHAI) CO., LTD.
    Inventor: Zhengwu Shen
  • Publication number: 20230040251
    Abstract: Disclosed are a benzimidazole derivative of formula (I), or an isomer, a pharmaceutically-acceptable salt, or a prodrug thereof, and a preparation thereof. An application of the benzimidazole derivative in the treatment of tumors is further provided.
    Type: Application
    Filed: September 19, 2022
    Publication date: February 9, 2023
    Inventor: Zhengwu SHEN
  • Patent number: 10881636
    Abstract: Described is a dihydroartemisinin-steroid conjugate of formula (I), or a pharmaceutically acceptable salt thereof, where position 10 of dihydroartemisinin is linked to the steroid through a linker X. This application further provides a preparation method of the dihydroartemisinin-steroid conjugate and an application of the dihydroartemisinin-steroid conjugate in the preparation of a drug for treating cancer. The dihydroartemisinin-steroid conjugate of the invention exhibits potent inhibitory activity against various tumor cells and low cytotoxicity, moreover, the conjugate is capable of penetrating the blood-brain barrier, having a broad application prospect.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: January 5, 2021
    Assignee: YUNBAIYAO ZHENGWU SCIENCE AND TECHNOLOGY (SHANGHAI) CO., LTD.
    Inventors: Jinghua Zhang, Zhengwu Shen
  • Publication number: 20200046679
    Abstract: Described is a dihydroartemisinin-steroid conjugate of formula (I), or a pharmaceutically acceptable salt thereof, where position 10 of dihydroartemisinin is linked to the steroid through a linker X. This application further provides a preparation method of the dihydroartemisinin-steroid conjugate and an application of the dihydroartemisinin-steroid conjugate in the preparation of a drug for treating cancer. The dihydroartemisinin-steroid conjugate of the invention exhibits potent inhibitory activity against various tumor cells and low cytotoxicity, moreover, the conjugate is capable of penetrating the blood-brain barrier, having a broad application prospect.
    Type: Application
    Filed: October 18, 2019
    Publication date: February 13, 2020
    Inventors: Jinghua Zhang, Zhengwu Shen
  • Patent number: 6255271
    Abstract: A fabric care composition comprises an amine or amide-epichlorohydrin resin or derivative thereof, a silicone component and, optionally, a textile compatible carrier. The textile compatible carrier facilitates contact between the resin and a fabric. The composition is adapted for use in the rinse cycle of a laundering process and may be used, as part of such a process, in the treatment of fabric to reduce creasing of the fabric.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: July 3, 2001
    Assignee: Unilever Home & Personal Care, USA, division of Conopco
    Inventors: Robert John Carswell, Anthony Nicholas Jarvis, Adelle Louise Killey, William Mooney, Andrew Philip Parker, Emily Jane Peckham, Zhengwu Shen