Patents by Inventor Zhengxi DAI

Zhengxi DAI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-CD47 ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20240417463
    Abstract: Provided herein are antibodies, masked antibodies (e.g., activatable antibodies), and antigen-binding fragments that target human CD47, polynucleotides encoding the same, therapeutic compositions thereof, and their use to treat CD47-positive diseases such as cancer. The masked antibodies described herein may comprise an IgG1 Fc region.
    Type: Application
    Filed: October 27, 2022
    Publication date: December 19, 2024
    Applicant: Adagene PTE. LTD.
    Inventors: Fangyong DU, Peter Peizhi LUO, Yan LI, Bin CAI, Jianfeng SHI, Jiangchun XU, Aaron NGUYEN, Songmao ZHENG, Guizhong LIU, Zhengxi DAI
  • Anti-CSF1R Molecules and Use Thereof
    Publication number: 20230203170
    Abstract: The disclosure relates to antibodies against human CSF-1R, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
    Type: Application
    Filed: December 23, 2020
    Publication date: June 29, 2023
    Inventors: Fangyong Du, Peter Peizhi Luo, Yan Li, Guizhong Liu, Xiaohong She, Zhengxi Dai
  • HETERODIMERIC PROTEINS WITH FC MUTATIONS
    Publication number: 20230124669
    Abstract: Provided are heterodimeric proteins comprising polypeptides having CH3 domains with engineered residues that form disulfide bonds and/or salt bridges. Also provided are activatable antibodies targeting CD3 and/or HER2. Compositions, methods of manufacture and methods of treatment using the heterodimeric proteins and the activatable antibodies are further provided.
    Type: Application
    Filed: January 22, 2021
    Publication date: April 20, 2023
    Applicants: Adagene AG
    Inventors: Peter Peizhi LUO, Fangyong DU, Guizhong LIU, Zhengxi DAI, Jianfeng SHI, Zhixiong LIN, Yan LI