Patents by Inventor Zhengxu Han

Zhengxu Han has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYCLOPROPYL ALKYL AMINES AND PROCESS FOR THEIR PREPARATION
    Publication number: 20200031753
    Abstract: The present invention relates to a process of making a compound of formula (I). Wherein, R is as defined herein.
    Type: Application
    Filed: March 28, 2018
    Publication date: January 30, 2020
    Inventors: Zhengxu HAN, Maurice A. MARSINI, Hao WU, Xingzhong ZENG
  • Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
    Patent number: 10442795
    Abstract: The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 and R3 are defined according to claim 1. Furthermore this inventions relates to intermediates obtained in these processes.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: October 15, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Xiao-Jun Wang, Wenjun Tang, Xiufeng Sun, Li Zhang, Dhileepkumar Krishnamurthy, Christopher Hugh Senanayake, Zhengxu Han
  • PROCESSES FOR PREPARING OF GLUCOPYRANOSYL-SUBSTITUTED BENZYL-BENZENE DERIVATIVES AND INTERMEDIATES THEREIN
    Publication number: 20150322053
    Abstract: The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 and R3 are defined according to claim 1. Furthermore this inventions relates to intermediates obtained in these processes.
    Type: Application
    Filed: July 22, 2015
    Publication date: November 12, 2015
    Inventors: Matthias ECKHARDT, Frank HIMMELSBACH, Xiao-Jun WANG, Wenjun TANG, Xiufeng SUN, Li ZHANG, Dhileepkumar KRISHNAMURTHY, Christopher Hugh SENANAYAKE, Zhengxu HAN
  • Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivates and intermediates therein
    Patent number: 9127034
    Abstract: The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 and R3 are defined according to claim 1. Furthermore this inventions relates to intermediates obtained in these processes.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: September 8, 2015
    Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Xiao-jun Wang, Wenjun Tang, Xiufeng Sun, Li Zhang, Dhileepkumar Krishnamurthy, Christopher Hugh Senanayake, Zhengxu Han
  • Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders
    Publication number: 20140315910
    Abstract: One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
    Type: Application
    Filed: June 27, 2014
    Publication date: October 23, 2014
    Inventors: Judy Caron, Thomas Wessel, Karim LALJI, Mark Varney, Roger P. Bakale, Surendra P. Singh, H. Scott Wilkinson, Xiping Su, Zhengxu Han, Stefan G. Koenig
  • Process for making novel chiral phosphorus ligands
    Patent number: 8816112
    Abstract: Disclosed are methods for making chiral phosphorus ligands including chiral phosphines, chiral phosphine oxides, phosphonamides, and aminophosphines. The chiral phosphorus ligands prepared by the methods of the invention are useful as components of chiral catalysts, e.g., transition metal complexes.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: August 26, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Zhengxu Han, Chris Hugh Senanayake
  • PROCESS FOR MAKING NOVEL CHIRAL PHOSPHORUS LIGANDS
    Publication number: 20140135506
    Abstract: Disclosed are methods for making chiral phosphorus ligands including chiral phosphines, chiral phosphine oxides, phosphonamides, and aminophosphines. The chiral phosphorus ligands prepared by the methods of the invention are useful as components of chiral catalysts, e.g., transition metal complexes.
    Type: Application
    Filed: November 14, 2013
    Publication date: May 15, 2014
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Zhengxu HAN, Chris Hugh SENANAYAKE
  • PROCESS FOR THE SYNTHESIS OF DERIVATIVES OF 3-AMINO-TETRAHYDROFURAN-3-CARBOXYLIC ACID AND USE THEREOF AS MEDICAMENTS
    Publication number: 20130005962
    Abstract: The present invention relates to a process for the manufacturing of substituted 3-amino-tetrahydrofuran-3-carboxylic acid amides of general formula (I) and their precursors in high optical purity to the precursors of the synthesis of substituted S-Amino-tetrahydrofuran-5-carboxylic acid amides of general formula (I) in high optical purity, and to the tautomers, enantiomers, diastereomers, mixtures and salts of substituted 3-amino-tetrahydrofuran-3-carboxylic acid amides of general formula (I) in high optical purity, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
    Type: Application
    Filed: September 11, 2012
    Publication date: January 3, 2013
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Zhengxu HAN, Kai GERLACH, Dhileepkumar KRISHNAMURTHY, Burkhard MATTHES, Herbert NAR, Roland PFAU, Henning PRIEPKE, Annette SCHULER-METZ, Chris H. SENANAYAKE, Peter SIEGER, Wenjun TANG, Wolfgang WIENEN, Yibo XU, Nathan K. YEE
  • Process for preparation of trans 4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1Napthalenamine
    Patent number: 8329950
    Abstract: One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
    Type: Grant
    Filed: January 25, 2012
    Date of Patent: December 11, 2012
    Assignee: Sunovion Pharmaceuticals Inc.
    Inventors: Judy Caron, Thomas Wessel, Karim Lalji, Mark Varney, Roger P. Bakale, Surendra P. Singh, H. Scott Wilkinson, Xiping Su, Zhengxu Han, Stefan G. Koenig
  • PROCESS FOR THE SYNTHESIS OF DERIVATIVES OF 3-AMINO-TETRAHYDROFURAN-3-CARBOXYLIC ACID AND USE THEREOF AS MEDICAMENTS
    Publication number: 20100317848
    Abstract: The present invention relates to a process for the manufacturing of substituted 3-amino-tetrahydrofuran-3-carboxylic acid amides of general formula (I) and their precursors in high optical purity to the precursors of the synthesis of substituted S-Amino-tetrahydrofuran-S-carboxylic acid amides of general formula (I) in high optical purity, and to the tautomers, enantiomers, diastereomers, mixtures and salts of substituted 3-amino-tetrahydrofuran-3-carboxylic acid amides of general formula (I) in high optical purity, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
    Type: Application
    Filed: December 21, 2007
    Publication date: December 16, 2010
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Zhengxu Han, Kai Gerlach, Dhileepkumar Krishnamurthy, Burkhard Matthes, Herbert Nar, Roland Pfau, Henning Priepke, Annette Schuler-Metz, Chris H. Senanayake, Peter Sieger, Wenjun Tang, Wolfgang Wienen, Yibo Xu, Nathan K. Yee
  • PROCESSES FOR PREPARING OF GLUCOPYRANOSYL-SUBSTITUTED BENZYL-BENZENE DERIVATES AND INTERMEDIATES THEREIN
    Publication number: 20100240879
    Abstract: The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 and R3 are defined according to claim 1. Furthermore this inventions relates to intermediates obtained in these processes.
    Type: Application
    Filed: May 28, 2010
    Publication date: September 23, 2010
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Matthias ECKHARDT, Frank HIMMELSBACH, Xiao-jun WANG, Wenjun TANG, Xiufeng SUN, Li ZHANG, Dhileepkumar KRISHNAMURTHY, Chris Hugh SENANAYAKE, Zhengxu HAN
  • Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
    Patent number: 7772191
    Abstract: The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 and R3 are defined according to claim 1. Furthermore this inventions relates to intermediates obtained in these processes.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: August 10, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Xiao-jun Wang, Wenjun Tang, Xiufeng Sun, Li Zhang, Dhileepkumar Krishnamurthy, Chris Hugh Senanayake, Zhengxu Han
  • Method of Preparing Amine Stereoisomers
    Publication number: 20080214870
    Abstract: This invention provides intermediates useful in a method of preparing amine stereoisomers. It also provides a method of preparing sulfoxide and sulfinylamine stereoisomers using certain of the intermediates.
    Type: Application
    Filed: February 18, 2008
    Publication date: September 4, 2008
    Inventors: Zhengxu Han, Dhileepkumar Krishnamurthy, Chris Hugh Senanayake, Zhi-Hui Lu
  • Method of preparing amine stereoisomers
    Patent number: 7332610
    Abstract: This invention provides intermediates useful in a method of preparing amine stereoisomers. It also provides a method of preparing sulfoxide and sulfinylamine stereoisomers using certain of the intermediates.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: February 19, 2008
    Assignee: Apsinterm LLC
    Inventors: Zhengxu Han, Dhileepkumar Krishnamurthy, Chris Hugh Senanayake, Zhi-Hui Lu
  • Methods of Preparing Sulfinamides and Sulfoxides
    Publication number: 20070293682
    Abstract: This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared.
    Type: Application
    Filed: July 30, 2007
    Publication date: December 20, 2007
    Inventors: Chris Senanayake, Zhengxu Han, Dhileepkumar Krishnamurthy, Derek Pflum, Harold Wilkinson
  • Methods of preparing sulfinamides and sulfoxides
    Patent number: 7256297
    Abstract: This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared.
    Type: Grant
    Filed: January 27, 2006
    Date of Patent: August 14, 2007
    Assignee: Apsinterm, LLC.
    Inventors: Chris Hugh Senanayake, Zhengxu Han, Dhileepkumar Krishnamurthy, Derek Pflum, Harold Scott Wilkinson
  • Method of preparing amine stereoisomers
    Publication number: 20060287539
    Abstract: This invention provides intermediates useful in a method of preparing amine stereoisomers. It also provides a method of preparing sulfoxide and sulfinylamine stereoisomers using certain of the intermediates.
    Type: Application
    Filed: September 1, 2006
    Publication date: December 21, 2006
    Inventors: Zhengxu Han, Dhileepkumar Krishnamurthy, Chris Hugh Senanayake, Zhi-Hui Lu
  • Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
    Publication number: 20060258749
    Abstract: The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 and R3 are defined according to claim 1. Furthermore this inventions relates to intermediates obtained in these processes.
    Type: Application
    Filed: May 3, 2006
    Publication date: November 16, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Xiao-jun Wang, Wenjun Tang, Xiufeng Sun, Li Zhang, Dhileepkumar Krishnamurthy, Christopher Senanayake, Zhengxu Han
  • Method of preparing amine stereoisomers
    Patent number: 7129378
    Abstract: This invention provides a method of preparing amine stereoisomers, which comprises stereoselectively reducing a sulfinylimine that bears on the sulfinyl group a residue of an alcohol, thiol or amine, or reacting a sulfinylimine stereoisomer that bears on the sulfinyl group a residue of an alcohol, thiol or amine with a source of a nucleophile, to afford a sulfinylamine stereoisomer, followed by contacting the sulfinylamine stereoisomer with a reagent suitable for the cleavage of a sulfur-nitrogen bond, to afford an amine stereoisomer. It also provides novel intermediates useful in the method, and the use of certain of the intermediates in the preparation of sulfoxide and sulfinylamine stereoisomers.
    Type: Grant
    Filed: April 7, 2003
    Date of Patent: October 31, 2006
    Assignee: Apsinterm, LLC
    Inventors: Zhengxu Han, Dhileepkumar Krishnamurthy, Chris Hugh Senanayake, Zhi-Hui Lu
  • Methods of preparing sulfinamides and sulfoxides
    Patent number: 7064214
    Abstract: This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: June 20, 2006
    Assignee: Apsinterm LLC
    Inventors: Chris Hugh Senanayake, Zhengxu Han, Dhileepkumar Krishnamurthy, Derek Pflum, Harold Scott Wilkinson