Abstract: Provided are a cell strain for producing a biosimilar drug of Ustekinumab and a production method therefor. Specifically, provided is a Chinese hamster ovary cell S cell strain. The cell strain expresses a full human monoclonal antibody directed against the P40 subunit shared by human IL-12 and human IL-23. The fully human monoclonal antibody directed against the P40 subunit shared by human IL-12 and human IL-23 is a biosimilar drug of Ustekinumab, which not only exhibits high consistency with Ustekinumab in pre-clinical research, but also passes pharmacokinetic bioequivalence and safety similarity evaluation in clinical research. The biosimilar drug of Ustekinumab is the first one that has entered clinical trials in China, is the only one that has completed the I stage clinical trial, and is also one of the biosimilar drugs of Ustekinumab, which has the fastest progress in new drug application in the world.

Abstract: An earphone and a mobile terminal is provided, in which the earphone includes a housing and a speaker assembly. The housing internally includes a front cavity and a rear cavity that are separated by the speaker assembly. The front cavity is located on a side that is of the speaker assembly and that is a sound output direction, and the rear cavity is located on an opposite side of the sound output direction of the speaker assembly. One or more sound guide channels are disposed in the housing, each sound guide channel is disposed in a sidewall of the housing, and each sound guide channel is configured to: when the earphone is normally worn, connect air inside an ear canal of a user to air outside the ear canal without connecting air in the front cavity to air in the rear cavity.

Abstract: Method for acquiring seismic data is described. The method includes obtaining undersampled seismic data acquired from a non-uniform sampling grid. Attenuating multiples from the undersampled seismic data.