Patents by Inventor Zhengyan Kan

Zhengyan Kan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetic variations associated with tumors
    Patent number: 9631240
    Abstract: Nucleotide and amino acid variations associated with tumors are provided. Methods for detecting variations and for diagnosing and treating tumors are provided.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: April 25, 2017
    Assignee: Genentech, Inc.
    Inventors: Zhengyan Kan, Denise M. Kenski, Brock Peters, Somasekar Seshagiri
  • GENETIC VARIATIONS ASSOCIATED WITH TUMORS
    Publication number: 20150010537
    Abstract: Nucleotide and amino acid variations associated with tumors are provided. Methods for detecting variations and for diagnosing and treating tumors are provided.
    Type: Application
    Filed: March 6, 2014
    Publication date: January 8, 2015
    Applicant: Genentech, Inc.
    Inventors: Zhengyan Kan, Denise M. Kenski, Brock Peters, Somasekar Seshagiri
  • Genetic variations associated with tumors
    Patent number: 8680041
    Abstract: Nucleotide and amino acid variations associated with tumors are provided. Methods for detecting variations and for diagnosing and treating tumors are provided.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: March 25, 2014
    Assignee: Genentech, Inc.
    Inventors: Zhengyan Kan, Denise M. Kenski, Brock Peters, Somasekar Seshagiri
  • GENETIC VARIATIONS ASSOCIATED WITH TUMORS
    Publication number: 20100092965
    Abstract: Nucleotide and amino acid variations associated with tumors are provided. Methods for detecting variations and for diagnosing and treating tumors are provided.
    Type: Application
    Filed: November 15, 2007
    Publication date: April 15, 2010
    Inventors: Somasekar Seshagiri, Brock Peters, Zhengyan Kan
  • GENETIC VARIATIONS ASSOCIATED WITH TUMORS
    Publication number: 20100055095
    Abstract: Nucleotide and amino acid variations associated with tumors are provided. Methods for detecting variations and for diagnosing and treating tumors are provided.
    Type: Application
    Filed: October 24, 2007
    Publication date: March 4, 2010
    Inventors: Zhengyan Kan, Denise M. Kenski, Brock Peters, Somasekar Seshagiri
  • Alternatively spliced isoform of phosphodiesterase 4B (PDE4B)
    Publication number: 20080102475
    Abstract: The present invention features nucleic acids and polypeptides encoding novel splice variant isoform of phosphodiesterase 4B (PDE4B). The polynucleotide sequence of PDE4Bsv1 is provided by SEQ ID NO: 3. The amino acid sequence of PDE4Bsv1 is provided by SEQ ID NO: 4. The present invention also provides methods for using PDE4B polynucleotides and proteins to screen for compounds that bind to PDE4B.
    Type: Application
    Filed: October 10, 2007
    Publication date: May 1, 2008
    Inventors: Zhengyan Kan, Philip Garrett-Engele, John Castle
  • Alternatively spliced isoform of acetyl-CoA carboxylase 2 (ACC2)
    Patent number: 7150969
    Abstract: The present invention features nucleic acids and polypeptides encoding novel splice variant isoforms of acetyl-CoA carboxylase 2 (ACC2). The polynucleotide sequence of ACC2sv1 is provided by SEQ ID NO 3. The amino acid sequence of ACC2sv1 is provided by SEQ ID NO 4. The present invention also provides methods for using ACC2sv1 polynucleotides and proteins to screen for compounds that bind to ACC2sv1.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: December 19, 2006
    Assignee: Rosetta Inpharmatics LLC
    Inventors: Zhengyan Kan, Philip W. Garrett-Engele, Christopher D. Armour, Christopher K. Raymond, John C. Castle
  • Alternatively spliced isoform of mitotic centromere-associated kinesin (MCAK)
    Publication number: 20060177828
    Abstract: The present invention features a nucleic acid and a polypeptide encoding a novel splice variant isoform of mitotic centromere-associated kinesin (MCAK). The polynucleotide sequence of MCAKsv1 is provided by SEQ ID NO 2. The amino acid sequence for MCAKsv1 is provided by SEQ ID NO 3. The present invention also provides methods for using MCAKsv1 polynucleotide and protein to screen for compounds that bind to MCAKsv1 and to screen for compounds that bind to other kinesin isoform polypeptides but not to MCAKsv1.
    Type: Application
    Filed: September 16, 2004
    Publication date: August 10, 2006
    Inventors: Christopher Armour, John Castle, Philip Garrett-Engele, Zhengyan Kan, Patrick Loerch, Nicholas Tsinoremas
  • Alternatively spliced isoform of acetyl-CoA carboxylase 2 (ACC2)
    Publication number: 20050272082
    Abstract: The present invention features nucleic acids and polypeptides encoding novel splice variant isoforms of acetyl-CoA carboxylase 2 (ACC2). The polynucleotide sequence of ACC2sv1 is provided by SEQ ID NO 3. The amino acid sequence of ACC2sv1 is provided by SEQ ID NO 4. The present invention also provides methods for using ACC2sv1 polynucleotides and proteins to screen for compounds that bind to ACC2sv1.
    Type: Application
    Filed: June 3, 2005
    Publication date: December 8, 2005
    Inventors: Zhengyan Kan, Philip Garrett-Engele, Christopher Armour, Christopher Raymond, John Castle
  • Alternatively spliced isoforms of interleukin-4 receptor subunit alpha (IL-4Ralpha)
    Publication number: 20050260650
    Abstract: The present invention features nucleic acids and polypeptides encoding a novel splice variant isoform of interleukin 4, subunit alpha (IL-4R?). The polynucleotide sequence of IL-4R?sv1 is provided by SEQ ID NO 4. The amino acid sequence for IL-4R?sv1 is provided by SEQ ID NO 5. The present invention also provides methods for using IL-4R?sv1 polynucleotides and proteins to screen for compounds that bind to IL-4R?sv1.
    Type: Application
    Filed: April 12, 2005
    Publication date: November 24, 2005
    Inventors: John Castle, Philip Garrett-Engele, Zhengyan Kan, Christopher Armour, Christopher Raymond
  • Alternatively spliced isoform of CDC25A phosphatase and methods of use
    Publication number: 20050176125
    Abstract: The present invention features nucleic acids and polypeptides encoding a novel splice variant isoform of cell division cycle 25A (Cdc25A) phosphatase. The polynucleotide sequence of Cdc25Asv1 is provided by SEQ ID NO:2. The amino acid sequence for Cdc25Asv1 is provided by SEQ ID NO:3. The present invention also provides methods for using Cdc25Asv1 polynucleotides and proteins to screen for compounds that bind to Cdc25Asv1.
    Type: Application
    Filed: December 22, 2004
    Publication date: August 11, 2005
    Applicant: Rosetta Inpharmatics LLC
    Inventors: John Castle, Christopher Armour, Philip Garrett-Engele, Zhengyan Kan, Christopher Raymond, Nicholas Tsinoremas
  • Alternatively spliced isoforms of sodium channel, voltage gated, type VIII, alpha (SCN8A)
    Publication number: 20050112633
    Abstract: The present invention features nucleic acids and polypeptides encoding three novel splice variant isoforms of sodium channel, voltage gated, type VIII, alpha (SCN8A). The polynucleotide sequences of SCN8Asv1.1, SCN8Asv1.2 and SCN8Asv2 are provided by SEQ ID NO 3, SEQ ID NO 5, and SEQ ID NO 7, respectively. The amino acid sequences for SCN8Asv1.1, SCN8Asv1.2, and SCN8Asv2 are provided by SEQ ID NO 4, SEQ ID NO 6, and SEQ ID NO 8, respectively. The present invention also provides methods for using SCN8Asv1.1, SCN8Asv1.2, and SCN8Asv2 polynucleotides and proteins to screen for compounds that bind to SCN8Asv1.1, SCN8Asv1.2, and SCN8Asv2, respectively.
    Type: Application
    Filed: September 16, 2004
    Publication date: May 26, 2005
    Inventors: Christopher Armour, John Castle, Philip Garrett-Engele, Zhengyan Kan, Patrick Loerch, Nicholas Tsinoremas
  • Alternatively spliced isoforms of nuclear factor kappa-B, subunit 1 (NFKB1)
    Publication number: 20050089912
    Abstract: The present invention features nucleic acids and polypeptides encoding two novel splice variant isoforms of nuclear factor kappa-B, subunit 1 (NFKB1). The polynucleotide sequences of NFKB1sv1 and NFKB1sv2 are provided by SEQ ID NO 3 and SEQ ID NO 5, respectively. The amino acid sequences for NFKB1sv1 and NFKB1sv2 are provided by SEQ ID NO 4 and SEQ ID NO 6, respectively. The present invention also provides methods for using NFKB1sv1 and NFKB1sv2 polynucleotides and proteins to screen for compounds that bind to NFKB1sv1 and NFKB1sv2, respectively.
    Type: Application
    Filed: October 6, 2004
    Publication date: April 28, 2005
    Inventors: Christopher Armour, John Castle, Philip Garrett-Engele, Zhengyan Kan, Christopher Raymond, Nicholas Tsinoremas
  • Alternatively spliced isoforms of receptor-interacting serine-threonine kinase 2 (RIPK2)
    Publication number: 20050059088
    Abstract: The present invention features nucleic acids and polypeptides encoding three novel splice variant isoforms of receptor-interacting serine-threonine kinase 2 (RIPK2). The polynucleotide sequences of RIPK2sv1.1, RIPK2sv1.2, and RIPK2s2 are provided by SEQ ID NO 1, SEQ ID NO 3, and SEQ ID NO 5, respectively. The amino acid sequences for RIPK2sv1.1, RIPK2sv1.2, and RIPK2sv2 are provided by SEQ ID NO 2, SEQ ID NO 4, and SEQ ID NO 6, respectively. The present invention also provides methods for using RIPK2sv1.1, RIPK2sv1.2, and RIPK2sv2 polynucleotides and proteins to screen for compounds that bind to RIPK2sv1.1, RIPK2sv1.2, and RIPK2sv2, respectively.
    Type: Application
    Filed: July 29, 2004
    Publication date: March 17, 2005
    Inventors: Christopher Armour, John Castle, Philip Garrett-Engele, Zhengyan Kan, Patrick Loerch, Nicholas Tsinoremas
  • Novel isoforms of centromere protein E (CENPE)
    Publication number: 20050003402
    Abstract: The present invention features nucleic acids and polypeptides encoding three novel variant isoform of centromere protein E (CENPE). The polynucleotide sequence of CENPEv2, CENPEv3, and CENPEv4 are provided by SEQ ID NO 6, SEQ ID NO 8, and SEQ ID NO 10, respectively. The amino acid sequences for CENPEv2, CENPEv3, and CENPEv4 are provided by SEQ ID NO 7, SEQ ID NO 9, and SEQ ID NO 11, respectively. The present invention also provides methods for using CENPEv2, CENPEv3, and CENPEv4 polynucleotides and proteins to screen for compounds that bind to CENPEv2, CENPEv3, and CENPEv4, respectively. The present invention also provides for methods to detect the presence of cancer and for inhibiting abnormal cell proliferation.
    Type: Application
    Filed: April 21, 2004
    Publication date: January 6, 2005
    Inventors: Christopher Armour, John Castle, Philip Garrett-Engele, Zhengyan Kan, Patrick Loerch, Nicholas Tsinoremas
  • Alternatively spliced isoforms of cysteine protease cathepsin K (CTSK)
    Publication number: 20040224341
    Abstract: The present invention features nucleic acids and polypeptides encoding two novel splice variant isoforms of cysteine protease cathepsin K (CTSK). The polynucleotide sequences of CTSKsv1.1 and CTSKsv1.2 are provided by SEQ ID NO 1 and SEQ ID NO 3, respectively. The amino acid sequences for CTSKsv1.1 and CTSKsv1.2 are provided by SEQ ID NO 2 and SEQ ID NO 4, respectively. The present invention also provides methods for using CTSKsv1.1 and CTSKsv1.2 polynucleotides and proteins to screen for compounds that bind to CTSKsv1.1 and CTSKsv1.2, respectively.
    Type: Application
    Filed: April 30, 2004
    Publication date: November 11, 2004
    Inventors: Christopher D. Armour, John C. Castle, Philip W. Garrett-Engele, Jason M. Johnson, Zhengyan Kan, Patrick M. Loerch
  • Alternatively spliced isoforms of inhibitor of kappa-B kinase gamma (IKBKG)
    Publication number: 20040175797
    Abstract: The present invention features nucleic acids and polypeptides encoding four novel splice variant isoforms of inhibitor of kappa light polypeptide gene enhancer in B cells, kinase of, gamma (IKBKG). The polynucleotide sequences of IKBKGsv1, IKBKGsv2.1, IKBKGsv2.2, and IKBKGsv3 are provided by SEQ ID NO 4, SEQ ID NO 6, SEQ ID NO 8, and SEQ ID NO 10, respectively. The amino acid sequences for IKBKGsv1, IKBKGsv2.1, IKBKGsv2.2, and IKBKGsv3 are provided by SEQ ID NO 5, SEQ ID NO 7, SEQ ID NO 9, and SEQ ID NO 11, respectively. The present invention also provides methods for using IKBKGsv1, IKBKGsv2.1, IKBKGsv2.2, and IKBKGsv3 polynucleotides and proteins to screen for compounds that bind to IKBKGsv1, IKBKGsv2.1, IKBKGsv2.2, and IKBKGsv3, respectively.
    Type: Application
    Filed: March 3, 2004
    Publication date: September 9, 2004
    Inventors: Jason M. Johnson, Philip W. Garrett-Engele, Zhengyan Kan