Patents by Inventor Zhengyin Yan

Zhengyin Yan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isotopically labeled trapping agent and method for identifying reactive metabolites
    Patent number: 7884186
    Abstract: The present invention is directed to an isotopically labeled trapping agent, methods for detecting reactive metabolites and methods of identifying drug candidates. More specifically, the isotopically labeled trapping agent and methods for detecting reactive metabolites may be used to detect both “hard” and “soft” reactive metabolites, thereby eliminating false positives.
    Type: Grant
    Filed: September 24, 2007
    Date of Patent: February 8, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Norman D. Huebert, Zhengyin Yan
  • Method for detecting reactive metabolites using a combination of glutathione and a stable isotopic derivative of glutathione and mass spectroscopy-based pattern recognition
    Patent number: 7445909
    Abstract: The present invention is directed to a method for detecting reactive metabolites using a combination of glutathione and a stable isotopic derivative of glutathione and mass spectroscopy. More specifically, the method selectively detects reactive metabolites by eliminating false positives arising from non-reactive components including both unreactive metabolites and components of the reaction mixture.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: November 4, 2008
    Assignee: Janssen Phamaceutica N.V.
    Inventors: Zhengyin Yan, Gary W. Caldwell
  • ISOTOPICALLY LABELED TRAPPING AGENT AND METHOD FOR IDENTIFYING REACTIVE METABOLITES
    Publication number: 20080081349
    Abstract: The present invention is directed to an isotopically labeled trapping agent, methods for detecting reactive metabolites and methods of identifying drug candidates. More specifically, the isotopically labeled trapping agent and methods for detecting reactive metabolites may be used to detect both “hard” and “soft” reactive metabolites, thereby eliminating false positives.
    Type: Application
    Filed: September 24, 2007
    Publication date: April 3, 2008
    Inventors: Norman D. Huebert, Zhengyin Yan
  • Method for detecting reactive metabolites using stable-isotope trapping and mass spectroscopy
    Publication number: 20050287623
    Abstract: The invention is directed to a method for detecting reactive metabolites using isotope trapping and mass spectroscopy.
    Type: Application
    Filed: June 22, 2005
    Publication date: December 29, 2005
    Inventors: Zhengyin Yan, Gary Caldwell