Patents by Inventor Zhengyuan Wu

Zhengyuan Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9447067
    Abstract: A method of preparing an intermediate of salmeterol (Compound 1, 2-amino-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol) includes: reacting compound 2 with 2-methoxypropene in a first organic solvent to produce a reaction solution including compound 3, compound 2 including a 2-bromo precursor of Compound 1; reacting compound 3 with a nitrogen source to produce compound 4; reacting compound 4 with sodium borohydride in a second organic solvent to produce compound 5; and debenzylating compound 5 by ammonium formate/palladium-carbon catalytic transfer hydrogenation in a third organic solvent to produce Compound 1. A method of preparing salmeterol includes preparing Compound 1, and reacting Compound 1 to prepare salmeterol.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: September 20, 2016
    Assignee: Amphastar Pahmaceuticals, Inc.
    Inventors: Yinhua Qiu, Zhengyuan Wu, Song Chen, Haoning Zhang
  • Publication number: 20160096863
    Abstract: A method of preparing a thioic acid intermediate of fluticasone propionate includes: treating a 17?-[(N,N-dimethyl carbamoyl)thio]carbonyl compound in a solution including an alcohol and an alkali metal hydroxide, an alkaline-earth metal hydroxide, or a mixture thereof to cleave an amide from the 17?-[(N,N-dimethyl carbamoyl)thio]carbonyl compound; treating the solution to separate an aqueous portion; and adding an acid to the aqueous portion to obtain the thioic acid intermediate of fluticasone propionate. A method of preparing fluticasone propionate includes preparing the thioic acid intermediate of fluticasone propionate, and alkylating the thioic acid intermediate of fluticasone propionate to prepare the fluticasone propionate.
    Type: Application
    Filed: April 16, 2015
    Publication date: April 7, 2016
    Inventors: Yinhua Qiu, Zhengyuan Wu, Yong Liu, Song Chen, Haoning Zhang
  • Publication number: 20160096816
    Abstract: A method of preparing an intermediate of salmeterol (Compound 1, 2-amino-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol) includes: reacting compound 2 with 2-methoxypropene in a first organic solvent to produce a reaction solution including compound 3, compound 2 including a 2-bromo precursor of Compound 1; reacting compound 3 with a nitrogen source to produce compound 4; reacting compound 4 with sodium borohydride in a second organic solvent to produce compound 5; and debenzylating compound 5 by ammonium formate/palladium-carbon catalytic transfer hydrogenation in a third organic solvent to produce Compound 1. A method of preparing salmeterol includes preparing Compound 1, and reacting Compound 1 to prepare salmeterol.
    Type: Application
    Filed: May 15, 2015
    Publication date: April 7, 2016
    Inventors: Yinhua Qiu, Zhengyuan Wu, Song Chen, Haoning Zhang
  • Patent number: 9303060
    Abstract: A method of preparing a thioic acid intermediate of fluticasone propionate includes: treating a 17?-[(N,N-dimethyl carbamoyl)thio]carbonyl compound in a solution including an alcohol and an alkali metal hydroxide, an alkaline-earth metal hydroxide, or a mixture thereof to cleave an amide from the 17?-[(N,N-dimethyl carbamoyl)thio]carbonyl compound; treating the solution to separate an aqueous portion; and adding an acid to the aqueous portion to obtain the thioic acid intermediate of fluticasone propionate. A method of preparing fluticasone propionate includes preparing the thioic acid intermediate of fluticasone propionate, and alkylating the thioic acid intermediate of fluticasone propionate to prepare the fluticasone propionate.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: April 5, 2016
    Assignee: Amphaster Pharmaceuticals, Inc.
    Inventors: Yinhua Qiu, Zhengyuan Wu, Yong Liu, Song Chen, Haoning Zhang