Patents by Inventor Zhengzhe LI

Zhengzhe LI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxadiazole inhibitors of HIPK2 for treating kidney fibrosis
    Patent number: 10669266
    Abstract: Compounds that are selective inhibitors of Smad3 activation are disclosed. The compounds have the following structure: in which Z is an oxadiazole. The compounds disclosed are useful in treatment of fibrotic disease, particularly renal fibrosis, and similar diseases associated with the dysregulation of the HIPK2/Smad3 signaling pathway.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: June 2, 2020
    Assignees: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, UNIVERSITY OF KANSAS
    Inventors: John Cijiang He, Ruijie Liu, Bhaskar Das, Wenzhen Xiao, Zhengzhe Li, Kyung Lee
  • OXADIAZOLE INHIBITORS OF HIPK2 FOR TREATING KIDNEY FIBROSIS
    Publication number: 20190352292
    Abstract: Compounds that are selective inhibitors of Smad3 activation are disclosed. The compounds have the following structure: in which Z is an oxadiazole. The compounds disclosed are useful in treatment of fibrotic disease, particularly renal fibrosis, and similar diseases associated with the dysregulation of the HIPK2/Smad3 signaling pathway.
    Type: Application
    Filed: January 5, 2018
    Publication date: November 21, 2019
    Applicants: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, UNIVERSITY OF KANSAS
    Inventors: John Cijiang HE, Ruijie LIU, Bhaskar DAS, Wenzhen XIAO, Zhengzhe LI, Kyung LEE