Patents by Inventor Zhenhai Gao
Zhenhai Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200385005Abstract: The present invention discloses a bend control optimization method and system. The bend control optimization method includes: acquiring lateral motion data of a vehicle, where the lateral motion data includes a steering angle; determining a lateral acceleration according to the lateral motion data; determining a longitudinal acceleration pre-correction amount of the vehicle according to the lateral motion data and the lateral acceleration; determining a longitudinal acceleration correction amount according to the longitudinal acceleration pre-correction amount; and adjusting longitudinal acceleration of the vehicle according to the longitudinal acceleration correction amount to assist the vehicle to conduct bend driving.Type: ApplicationFiled: February 27, 2020Publication date: December 10, 2020Inventors: Zhenhai GAO, Yiteng SUN, Hongyu HU, Fei GAO, Yichi ZHANG, Naixuan ZHU, Yuhuan SHENG
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Patent number: 10576859Abstract: The present invention provides an array type automobile seat profile adaptive-adjusting apparatus, comprising a seat back plate, a seat bottom plate, a seat profile layer covered thereon and a plurality of shape memory material actuators which are arranged in a rectangular array and are disposed between the seat profile layer and the seat back plate and between the seat profile layer and the seat bottom plate, wherein each of the shape memory material actuators comprises a plurality of sequentially nested sleeves, a return spring through which an outwardly extending elastic force is applied to the sleeves, a pulley block fixedly arranged in the sleeve located at a tail end, and a memory alloy wire which is in a shape of filament and is wound on the pulley block.Type: GrantFiled: December 17, 2017Date of Patent: March 3, 2020Inventors: Zhenhai Gao, Chuanliang Shen, Binyu Zhou, Tairong Sun, Fei Gao
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Publication number: 20190135150Abstract: The present invention provides an array type automobile seat profile adaptive-adjusting apparatus, comprising a seat back plate, a seat bottom plate, a seat profile layer covered thereon and a plurality of shape memory material actuators which are arranged in a rectangular array and are disposed between the seat profile layer and the seat back plate and between the seat profile layer and the seat bottom plate, wherein each of the shape memory material actuators comprises a plurality of sequentially nested sleeves, a return spring through which an outwardly extending elastic force is applied to the sleeves, a pulley block fixedly arranged in the sleeve located at a tail end, and a memory alloy wire which is in a shape of filament and is wound on the pulley block.Type: ApplicationFiled: December 17, 2017Publication date: May 9, 2019Inventors: ZHENHAI GAO, CHUANLIANG SHEN, BINYU ZHOU, TAIRONG SUN, FEI GAO
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Patent number: 9163057Abstract: The present invention provides a method of myocardial perfusion imaging using reduced doses of (1-{9-[(4S,2R,3R,5R)3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazol-4-yl)-N-methylcarboxamide.Type: GrantFiled: August 29, 2013Date of Patent: October 20, 2015Assignee: Gilead Sciences, Inc.Inventors: Luiz Belardinelli, Brent K. Blackburn, Zhenhai Gao
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Publication number: 20150023867Abstract: The present invention provides a method of myocardial perfusion imaging using reduced doses of (1-{9-[(4S,2R,3R,5R)3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazol-4-yl)-N-methylcarboxamide.Type: ApplicationFiled: August 29, 2013Publication date: January 22, 2015Applicant: Gilead Sciences, Inc.Inventors: Luiz Belardinelli, Brent K. Blackburn, Zhenhai Gao
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Publication number: 20140005070Abstract: The invention provides methods of monitoring differential gene expression of pharmacodynamic (PD) markers in a patient treated with a Cyclin Dependent Kinase Inhibitor (CDKI), methods of determining the sensitivity of a cell to a CDKI by measuring PD markers and methods of screening for candidate CKDI.Type: ApplicationFiled: March 28, 2012Publication date: January 2, 2014Applicant: Novartis AGInventors: Michel Faure, Zhenhai Gao, James Sutton, Guoying Karen Yu
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Patent number: 8536150Abstract: The present invention provides a method of myocardial perfusion imaging using reduced doses of (1-{9-[(4S,2R,3R,5R)3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazol-4-yl)-N-methylcarboxamide.Type: GrantFiled: June 15, 2012Date of Patent: September 17, 2013Assignee: Gilead Sciences, Inc.Inventors: Luiz Belardinelli, Brent K. Blackburn, Zhenhai Gao
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Publication number: 20120251440Abstract: The present invention provides a method for identifying and using partial adenosine A2A receptor agonists that are useful as adjuncts in myocardiological perfusion imaging.Type: ApplicationFiled: June 15, 2012Publication date: October 4, 2012Applicant: Gilead Sciences, Inc.Inventors: Luiz Belardinelli, Brent K. Blackburn, Zhenhai Gao
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Patent number: 8071566Abstract: The present invention provides methods of myocardial perfusion imaging and increasing coronary blood flow of a mammal that are accomplished by administering doses of a compound that is a selective partial A2A receptor agonist with a short duration of action, in particular regadenoson, useful for, among other indications, myocardial imaging and coronary vasodilation, and determining areas of insufficient blood flow.Type: GrantFiled: May 4, 2009Date of Patent: December 6, 2011Assignee: Gilead Sciences, Inc.Inventors: Luiz Belardinelli, Brent K. Blackburn, Zhenhai Gao
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Patent number: 7671059Abstract: Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.Type: GrantFiled: September 28, 2006Date of Patent: March 2, 2010Assignee: Novartis AGInventors: Timothy D. Machajewski, Cynthia M. Shafer, Christopher McBride, William Antonios-McCrea, Brandon M. Doughan, Barry H. Levine, Yi Xia, Maureen McKenna, X. Michael Wang, Kris Mendenhall, Yasheen Zhou, Kristin Brinner, Zhenhai Gao, Daniel Poon, Paul Barsanti, Xiaodong Lin, Abran Costales, Alice Rico, Nathan Brammeier, Teresa Pick, Paul A. Renhowe
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Publication number: 20100004237Abstract: Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.Type: ApplicationFiled: July 31, 2009Publication date: January 7, 2010Inventors: Timothy D. Machakewski, Cynthia M. Shafer, Christopher McBride, William Antonios-McCrea, Brandon M. Doughan, Barry H. Levine, Yi Xia, Maureen McKenna, X. Michael Wang, Kris Mendenhall, Yasheen Zhou, Baoqing Gong, Dan Gu, John Dolan, John Tulinsky, Kristin Brinner, Zhenhai Gao, Daniel Poon, Paul Barsanti, Xiaodong Lin, Abran Costales, Alice Rico, Nathan Brammeier, Teresa Pick, Paul A. Renhowe
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Publication number: 20090317331Abstract: The present invention provides a method for identifying and using partial adenosine A2A receptor agonists that are useful as adjuncts in myocardiological perfusion imaging.Type: ApplicationFiled: May 4, 2009Publication date: December 24, 2009Inventors: Luiz Belardinelli, Brent K. Blackburn, Zhenhai Gao
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Patent number: 7582617Abstract: The present invention provides a method for using the partial adenosine A2A receptor agonists having the following structure in myocardiological perfusion imaging.Type: GrantFiled: March 2, 2005Date of Patent: September 1, 2009Assignee: CV Therapeutics, Inc.Inventors: Luiz Belardinelli, Brent K. Blackburn, Zhenhai Gao
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Publication number: 20070123546Abstract: Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.Type: ApplicationFiled: September 28, 2006Publication date: May 31, 2007Inventors: Timothy Machajewski, Cynthia Shafer, Christopher McBride, William Antonios-McCrea, Brandon Doughan, Barry Levine, Yi Xia, Maureen McKeena, X. Wang, Kris Mendenhall, Yasheen Zhou, Baoquing Gong, Dan Gu, John Dolan, John Tulinsky, Kristin Brinner, Zhenhai Gao
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Publication number: 20070027150Abstract: 2-Amino-quinazolin-5-one compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cell proliferative diseases.Type: ApplicationFiled: April 14, 2006Publication date: February 1, 2007Inventors: Cornelia Bellamacina, Abran Costales, Brandon Doughan, Susan Fong, Zhenhai Gao, Thomas Hendrickson, Barry Levine, Xiaodong Lin, Timothy Machajewski, Christopher McBride, William Antonios-McCrea, Maureen McKenna, Kris Mendenhall, Alice Rico, Cynthia Shafer, X. Wang, Yi Xia, Yasheen Zhou
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Publication number: 20050175535Abstract: The present invention provides a method for identifying and using partial adenosine A2A receptor agonists that are useful as adjuncts in myocardiological perfusion imaging.Type: ApplicationFiled: March 2, 2005Publication date: August 11, 2005Inventors: Luiz Belardinelli, Brent Blackburn, Zhenhai Gao
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Publication number: 20040137533Abstract: The present invention provides a method for identifying and using partial adenosine A2A receptor agonists that are useful as adjuncts in myocardiological perfusion imaging.Type: ApplicationFiled: July 2, 2003Publication date: July 15, 2004Applicant: CV Therapeutics, Inc.Inventors: Luiz Belardinelli, Brent K. Blackburn, Zhenhai Gao
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Patent number: 6576620Abstract: The present invention provides a method for identifying partial adenosine A1 receptor agonists that are useful in the treatment of arrhythmias. Partial adenosine A1 receptor agonists and methods for using partial adenosine A1 receptor agonists to treat arrhythmias in mammals.Type: GrantFiled: December 1, 2000Date of Patent: June 10, 2003Assignee: CV Therapeutics, Inc.Inventors: Luiz Belardinelli, Zhenhai Gao
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Publication number: 20020012946Abstract: The present invention provides a method for identifying and using partial adenosine A2A receptor agonists that are useful as adjuncts in myocardiological perfusion imaging.Type: ApplicationFiled: February 23, 2001Publication date: January 31, 2002Inventors: Luiz Belardinelli, Brent K. Blackburn, Zhenhai Gao
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Publication number: 20010008883Abstract: The present invention provides a method for identifying parital adenosine A1 receptor agonists that are useful in the treatment of arrhythmias. Partial adenosine A1 receptor agonists and methods for using partial adenosine A1 receptor agonists to treat arrhythmias in mammals.Type: ApplicationFiled: December 1, 2000Publication date: July 19, 2001Inventors: Luiz Belardinelli, Zhenhai Gao