Patents by Inventor Zhenhong R. Cai

Zhenhong R. Cai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
    Patent number: 9630978
    Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A, A?, R1 and R2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: April 25, 2017
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Zhenhong R. Cai, Haolun Jin, Scott E. Lazerwith, Hyung-Jung Pyun
  • POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
    Publication number: 20170057976
    Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: November 11, 2016
    Publication date: March 2, 2017
    Inventors: Haolun Jin, Scott E. Lazerwith, Hyung-Jung Pyun, Manoj C. Desai, Teresa Alejandra Trejo, Elizabeth Bacon, Jeromy J. Cottell, Zhenhong R. Cai, Philip Anthony Morganelli, Mingzhe Ji, James G. Taylor, Xiaowu Chen, Michael R. Mish
  • Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
    Patent number: 9522912
    Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A?, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: December 20, 2016
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Elizabeth M. Bacon, Zhenhong R. Cai, Jeromy J. Cottell, Mingzhe Ji, Haolun Jin, Scott E. Lazerwith, Philip Anthony Morganelli, Hyung-jung Pyun
  • POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
    Publication number: 20160289246
    Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A, A?, R1 and R2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: April 1, 2016
    Publication date: October 6, 2016
    Inventors: Zhenhong R. Cai, Haolun Jin, Scott E. Lazerwith, Hyung-Jung Pyun
  • SUBSTITUTED 1,2,3,4,6,8,12,12a-OCTAHYDRO-1,4-METHANODIPYRIDO[1,2-a:1',2'-d]PYRAZINES AND METHODS FOR TREATING VIRAL INFECTIONS
    Publication number: 20160176885
    Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: July 31, 2015
    Publication date: June 23, 2016
    Inventors: Haolun Jin, Scott E. Lazerwith, Hyung-Jung Pyun, Manoj C. Desai, Teresa Alejandra Trejo Martin, Elizabeth Bacon, Jeromy J. Cottell, Zhenhong R. Cai, Philip Anthony Morganelli, Mingzhe Ji, James G. Taylor, Xiaowu Chen, Michael R. Mish
  • POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
    Publication number: 20160176870
    Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A?, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: December 21, 2015
    Publication date: June 23, 2016
    Inventors: Elizabeth M. Bacon, Zhenhong R. Cai, Jeromy J. Cottell, Mingzhe Ji, Haolun Jin, Scott E. Lazerwith, Philip Anthony Morganelli, Hyung-jung Pyun
  • Antiviral compounds
    Patent number: 8927484
    Abstract: The present application includes novel inhibitors of HCV, compositions containing such compounds, therapeutic methods that include the administration of such compounds.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: January 6, 2015
    Assignee: Gilead Sciences, Inc.
    Inventors: Zhenhong R. Cai, Michael O'Neil Hanrahan Clarke, Edward Doerffler, Mingzhe Ji, Choung U. Kim, Hyung-jung Pyun, Xiaoning C. Sheng, Qiaoyin Wu
  • POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
    Publication number: 20140221356
    Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: December 19, 2013
    Publication date: August 7, 2014
    Inventors: Haolun JIN, Scott E. LAZERWITH, Teresa Alejandra TREJO MARTIN, Elizabeth M. BACON, Jeromy J. COTTELL, Zhenhong R. CAI, Hyung-Jung PYUN, Philip Anthony MORGANELLI, Mingzhe JI, James G. TAYLOR, Xiaowu CHEN, Michael R. MISH, Manoj C. DESAI
  • INHIBITORS OF HEPATITIS C VIRUS
    Publication number: 20120053148
    Abstract: The present application includes novel inhibitors of HCV, compositions containing such compounds, therapeutic methods that include the administration of such compounds.
    Type: Application
    Filed: June 9, 2011
    Publication date: March 1, 2012
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Zhenhong R. Cai, Zhimin Du, Mingzhe Ji, Haolun Jin, Choung U. Kim, Michael R. Mish, Barton W. Phillips, Hyung-jung Pyun, Xiaoning C. Sheng, Qiaoyin Wu, Catalin Sebastian Zonte
  • Integrase inhibitors
    Patent number: 8008287
    Abstract: Tricyclic compounds, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
    Type: Grant
    Filed: May 16, 2007
    Date of Patent: August 30, 2011
    Assignee: Gilead Sciences, Inc.
    Inventors: Zhenhong R. Cai, Salman Y. Jabri, Haolun Jin, Rachael A. Lansdown, Samuel E. Metobo, Michael R. Mish, Richard M. Pastor
  • ANTIVIRAL COMPOUNDS
    Publication number: 20110135599
    Abstract: The present application includes novel inhibitors of HCV, compositions containing such compounds, therapeutic methods that include the administration of such compounds.
    Type: Application
    Filed: December 1, 2010
    Publication date: June 9, 2011
    Applicant: Gilead Sciences, Inc.
    Inventors: Zhenhong R. Cai, Michael O'Neil Hanrahan Clarke, Edward Doerffler, Mingzhe Ji, Choung U. Kim, Hyung-jung Pyun, Xiaoning C. Sheng, Qiaoyin Wu
  • INTEGRASE INHIBITORS
    Publication number: 20090306054
    Abstract: Tricyclic compounds of formulae I-III, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
    Type: Application
    Filed: May 16, 2007
    Publication date: December 10, 2009
    Applicant: Gilead Sciences ,Inc.
    Inventors: Zhenhong R. Cai, Salman Y. Jabri, Haolun Jin, Rachel A. Lansdown, Samuel E. Metobo, Michael R. Mish, Richard M. Pastor
  • Antiviral compounds
    Publication number: 20090047252
    Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: June 26, 2008
    Publication date: February 19, 2009
    Applicant: Gilead Sciences, Inc.
    Inventors: Zhenhong R. Cai, Aesop Cho, Choung U. Kim, Jie Xu
  • Antiviral compounds
    Publication number: 20080076740
    Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: July 27, 2006
    Publication date: March 27, 2008
    Inventors: Zhenhong R. Cai, Salman Y. Jabri, Haolun Jin, Choung U. Kim, Samuel E. Metobo, Michael R. Mish, Richard M. Pastor