Abstract: Anaphthalene ring-containing compound, a pharmaceutical composition containing same, and the use thereof. A naphthalene ring-containing compound as represented by formula III, a pharmaceutically acceptable salt thereof, a solvate thereof, or a solvate of the pharmaceutically acceptable salt thereof. The compound is new in structure and has a better activity on cancers.

Abstract: This application discloses a relay selection method and apparatus, a relay information transmission method and apparatus, and a terminal, and pertains to the technical field of communications. The method in the embodiments of this application includes: receiving, by a remote terminal, first information sent by a relay terminal, where the first information includes at least one of a relay hop count N or quality of service (QoS) information of the relay terminal, N represents an Nth hop of the relay terminal in a relay link, and N is a positive integer; and performing, by the remote terminal, relay terminal selection based on the first information.

Abstract: The present invention relates to an experimental apparatus for researching characteristics of subsea tunnel at bottom of seabed under wave, comprising main control system, wave making test system, rock and soil confining pressure test system and water level regulation test system, wherein a bottom of the rock and soil confining pressure test system is connected with the water level regulation test system; a bottom of the wave making test system is connected with the rock and soil confining pressure test system; and all test systems are electrically connected with the main control system. The experimental apparatus, when being small, may simulate the situation of the subsea tunnel under a nonlinear complex wave, may consider the common action of the seabed and the wave, and may regulate water levels and soil pressures, having perfect functions and effectively exploring the effect of various aspects on the subsea tunnel.

Abstract: Provided are a battery, an electrical apparatus, and a method and an apparatus for making a battery. The battery comprises: a battery cell; a first component, wherein a first surface of the first component is connected to at least one of the battery cells through an adhesion member, the adhesion member comprises a first adhesion structure and a second adhesion structure, the first adhesion structure is located at the periphery of the second adhesion structure, and the first adhesion structure has an elongation at break greater than that of the second adhesion structure. The battery, the electrical apparatus, and the method and the apparatus for making the battery according to the embodiments of the present application can enhance the safety of the battery.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Disclosed is a sub-Kelvin temperature zone refrigeration mechanism. The sub-Kelvin temperature zone refrigeration mechanism includes a pulse tube refrigeration unit, first pre-cooling heat exchangers, a throttling refrigeration unit, second pre-cooling heat exchangers, an adsorption refrigeration unit, a third pre-cooling heat exchanger and a dilution refrigeration unit. The pulse tube refrigeration unit includes a pulse tube refrigeration part. The throttling refrigeration unit includes a throttling refrigeration part, and the throttling refrigeration part is connected with the adsorption refrigeration unit through the second pre-cooling heat exchangers so as to pre-cool the adsorption refrigeration unit. The adsorption refrigeration unit includes an adsorption refrigeration part, and the adsorption refrigeration part is connected with the dilution refrigeration unit through the third pre-cooling heat exchanger.

Abstract: The present invention belongs to the technical field of ocean traffic engineering, and relates to a fabricated ocean tunnel structure with an escape device and an application method thereof. The present invention includes a fabricated ocean tunnel structure and an escape device. the partition plate separates a middle bin in the tunnel, and the escape device is connected into the middle bin; and the escape device includes a rescue capsule, transverse ladders are evenly arranged in the rescue capsule, and a balancing weight block and a rescue equipment area are arranged at the bottom of the rescue capsule. The ocean tunnel structure can be provided with a rescue device during installation, and the safety of personnel escape can be guaranteed; therefore, the safety of the ocean tunnel structure is improved, cost is relatively low, secondary damage to the ocean tunnel structure is not needed.

Abstract: The present invention relates to method for filling deformable karst cave, and the steps are: penetrating a grouting pipe into an elastic silicone tube, penetrating the grouting pipe and the elastic silicone tube into a deformable bracket, and lowering into a karst cave; sealing the elastic silicone tube, injecting silicate resin materials into the grouting pipe, and injecting steel fiber reinforced grout to implement a “block stone-like” structure; sealing the elastic silicone tube, separating the “block stone-like” structure from the elastic silicone tube to complete a “block stone-like” structure; lowering the elastic silicone tube and the deformable bracket, sealing the elastic silicone tube, lowering the elastic silicone tube and the deformable bracket tore construct the “block stone-like” structure, and completing the filling. The present invention may effectively stabilize the karst cave, ensure safe tunnel construction and stable surrounding rocks, and improve engineering construction speed.

Abstract: Provided are a method and apparatus for evaluating a degree of frequency regulation urgency of a generator set, a power system and a storage medium.

Abstract: A signal processing system and method for a radiation detector based on a metal oxide semiconductor (MOS) transistor are disclosed. The signal processing system includes a power supply generation module, an analog signal processing module, and a digital signal acquiring-processing module. The power supply generation module provides a novel power supply method, and converts a positive high voltage power supply into a negative high voltage power supply to supply power to a last dynode of a photomultiplier tube (PMT). The analog signal processing module converts a negative current pulse signal into a voltage difference signal. The digital signal acquiring-processing module acquires a signal of the analog signal processing module, and converts the signal into a digital signal for identification.

Abstract: Provided are a method and system for visualization of a 3D electronic device. The method includes: a structural and/or electrical characteristic of the electronic device is simulated to obtain first visualization data, the electronic device including a semiconductor device and/or an integrated circuit and the first visualization data including 3D grid position information of the electronic device and/or a physical quantity at a grid point; the 3D grid position information and/or physical quantity at the grid point in the first visualization data are/is converted into second visualization data suitable for virtual 3D displaying according to a data type; and the second visualization data is rendered in a virtual space to display a structure and/or physical quantity of the electronic device in the virtual space.

Abstract: The present invention provides an anti-SIRP? antibody and an antigen binding fragment thereof, being capable of effectively blocking the binding of SIRP? and CD47, thereby effectively promoting the phagocytosis of macrophages to tumor cells, effectively inhibiting the growth of tumors, and having a good pharmaceutical prospect.

Abstract: The present invention provides composites with controllable superhydrophilic and superhydrophobic performances, a 3D printing method and 3D printed parts. The composites with controllable superhydrophilic and superhydrophobic interface performances comprise hydrophobic powder and/or hydrophilic powder and jointing phase powder, wherein the jointing phase powder is thermoplastic polymers. The present invention can print the parts with a continuous wettability change from superhydrophilic to superhydrophobic performances by regulating the mass percentage of the hydrophobic powder, the hydrophilic powder and the jointing phase powder. Furthermore, the present invention can prepare the models with various shapes according to different application scenes, and regulate the interface wettability performances of the models.

Abstract: The present invention provides composites with controllable superhydrophilic and superhydrophobic performances, a 3D printing method and 3D printed parts. The composites with controllable superhydrophilic and superhydrophobic interface performances comprise hydrophobic powder and/or hydrophilic powder and jointing phase powder, wherein the jointing phase powder is thermoplastic polymers. The present invention can print the parts with a continuous wettability change from superhydrophilic to superhydrophobic performances by regulating the mass percentage of the hydrophobic powder, the hydrophilic powder and the jointing phase powder. Furthermore, the present invention can prepare the models with various shapes according to different application scenes, and regulate the interface wettability performances of the models.

Abstract: A compound represented by the following general formula, a preparation method thereof, a pharmaceutical composition containing the compound, and a use of the compound in preparation of drugs for preventing and/or treating EGFR kinase-mediated cancers and other diseases.

Abstract: A nucleic acid comprising a first nucleic acid region comprising a nucleic acid sequence encoding a SMN protein or variant thereof; and a second nucleic acid region comprising one or more target segment(s) of one or more endogenous microRNA(s), wherein the second nucleic acid region is at 3? of the first nucleic acid region.

Abstract: The present invention relates to an alkenyl pyrimidine compound, a preparation method therefor, and an application thereof. Particularly, the present invention relates to a compound having EGFR inhibitory activity and a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, a preparation method thereof, a pharmaceutical composition containing the compound, and a use of the compound in the preparation of drugs for preventing and/or treating cancer and other diseases mediated by EGFR kinase.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.