Abstract: A message sending method includes receiving a first message, where the first message includes review comment information corresponding to a first code, the first code is uploaded by a first user to a code repository via a first client, the review comment information includes related information of a comment provided by a second user for the first code, and the second user is a developer corresponding to the first code; and sending a second message to the first client, where the second message includes the review comment information, and the second message indicates the first client to synchronously display the review comment information and the first code based on a development environment of the first code.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: The present disclosure discloses an automatic leveling control method for a four-leg support working platform, which comprises the steps: determining the mass center position of the working platform, determining the main bearing quadrant and distinguishing active legs from the driven leg; adjusting the driven leg to weak state, controlling all legs to synchronously actuate for leveling; calculating the limit compensating actuation length of the driven leg, and performing compensating actuation until accomplishing the leveling process. The method is advantageous in: high speed, high robustness, no repeated oscillation. The mass center always stays within the bearing zone of the active legs, thus completely eliminating capsizing risk of the working platform. The compensating actuation of the driven leg ensures there is no weak leg, and hence high attitude and load-bearing stability of the working platform is achieved.

Abstract: Provided are a three-dimensional stack field-effect transistor (3DS FET) and a method of manufacturing the same. According to embodiments, the 3DS FET includes: a lower active region arranged on a substrate, an upper active region above the lower active region and a gate stack. The lower active region includes: a fin extending in a first direction on the substrate, and lower source/drain portions at two opposite ends of the fin in the first direction, respectively. The upper active region includes: one or more nanosheets, a lowest nanosheet is spaced apart from the fin in a vertical direction relative to the substrate, and upper source/drain portions at two opposite ends of the one or more nanosheets in the first direction, respectively. The gate stack extends in a second direction intersecting with the first direction so as to intersect with the fin and the one or more nanosheets.

Abstract: The disclosure provides a sealing system applicable for an ocean power generation device, which includes at least one first seal and a water leakage protection device. The water leakage protection device is located at a side of at least one first seal away from seawater, and includes a sealed water storage tank and a drain pipe. The sealed water storage tank collects and stores seawater leaked from the at least one first seal. One end of the drain pipe is communicated with the sealed water storage tank, and the seawater stored in the sealed water storage tank is discharged through the drain pipe.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: A polypeptide comprising two or three VEGF binding domains; and a domain that binds to an angiopoietin, and a gene therapy for delivering such a polypeptide.

Abstract: The invention provides a disperse dye color paste for waterless dyeing, which comprises, by weight, 10%-40% of disperse dye filter cakes, 2%-35% of a dispersant, 5%-20% of a dyeing auxiliary, 0.1-0.5% of a surfactant, and 20%-88% of a solvent. The disperse dye color paste for waterless dyeing of the invention has a small particle size; and after waterless dyeing, a textile does not contain cleavable carcinogenic aromatic amine azo dyes, allergenic dyes, forbidden aromatic amine or bioactive substances. The disperse dye color paste for waterless dyeing of the invention can be stably stored for 6-12 months which is beneficial to the transportation of dyes and the production management of dyeing factories. Moreover, a dyeing effect featuring a high fixation rate is realized after the disperse dye color paste for waterless dyeing is applied to textiles.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Provided are a method and system for visualization of a 3D electronic device. The method includes: a structural and/or electrical characteristic of the electronic device is simulated to obtain first visualization data, the electronic device including a semiconductor device and/or an integrated circuit and the first visualization data including 3D grid position information of the electronic device and/or a physical quantity at a grid point; the 3D grid position information and/or physical quantity at the grid point in the first visualization data are/is converted into second visualization data suitable for virtual 3D displaying according to a data type; and the second visualization data is rendered in a virtual space to display a structure and/or physical quantity of the electronic device in the virtual space.

Abstract: The present invention provides an anti-SIRP? antibody and an antigen binding fragment thereof, being capable of effectively blocking the binding of SIRP? and CD47, thereby effectively promoting the phagocytosis of macrophages to tumor cells, effectively inhibiting the growth of tumors, and having a good pharmaceutical prospect.

Abstract: The present invention provides composites with controllable superhydrophilic and superhydrophobic performances, a 3D printing method and 3D printed parts. The composites with controllable superhydrophilic and superhydrophobic interface performances comprise hydrophobic powder and/or hydrophilic powder and jointing phase powder, wherein the jointing phase powder is thermoplastic polymers. The present invention can print the parts with a continuous wettability change from superhydrophilic to superhydrophobic performances by regulating the mass percentage of the hydrophobic powder, the hydrophilic powder and the jointing phase powder. Furthermore, the present invention can prepare the models with various shapes according to different application scenes, and regulate the interface wettability performances of the models.

Abstract: The present invention provides composites with controllable superhydrophilic and superhydrophobic performances, a 3D printing method and 3D printed parts. The composites with controllable superhydrophilic and superhydrophobic interface performances comprise hydrophobic powder and/or hydrophilic powder and jointing phase powder, wherein the jointing phase powder is thermoplastic polymers. The present invention can print the parts with a continuous wettability change from superhydrophilic to superhydrophobic performances by regulating the mass percentage of the hydrophobic powder, the hydrophilic powder and the jointing phase powder. Furthermore, the present invention can prepare the models with various shapes according to different application scenes, and regulate the interface wettability performances of the models.

Abstract: A compound represented by the following general formula, a preparation method thereof, a pharmaceutical composition containing the compound, and a use of the compound in preparation of drugs for preventing and/or treating EGFR kinase-mediated cancers and other diseases.

Abstract: A nucleic acid comprising a first nucleic acid region comprising a nucleic acid sequence encoding a SMN protein or variant thereof; and a second nucleic acid region comprising one or more target segment(s) of one or more endogenous microRNA(s), wherein the second nucleic acid region is at 3? of the first nucleic acid region.

Abstract: The present invention relates to an alkenyl pyrimidine compound, a preparation method therefor, and an application thereof. Particularly, the present invention relates to a compound having EGFR inhibitory activity and a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, a preparation method thereof, a pharmaceutical composition containing the compound, and a use of the compound in the preparation of drugs for preventing and/or treating cancer and other diseases mediated by EGFR kinase.

Abstract: The present disclosure discloses an automatic leveling control method for a four-leg support working platform, which comprises the steps: determining the mass center position of the working platform, determining the main bearing quadrant and distinguishing active legs from the driven leg; adjusting the driven leg to weak state, controlling all legs to synchronously actuate for leveling; calculating the limit compensating actuation length of the driven leg, and performing compensating actuation until accomplishing the leveling process. The method is advantageous in: high speed, high robustness, no repeated oscillation. The mass center always stays within the bearing zone of the active legs, thus completely eliminating capsizing risk of the working platform. The compensating actuation of the driven leg ensures there is no weak leg, and hence high attitude and load-bearing stability of the working platform is achieved.