Abstract: The invention relates to synthetic liver-specific promoters and expression constructs for producing polypeptides and functional nucleic acids in the liver of a subject. The invention further relates to Factor VIII proteins containing modifications in the amino acid sequence of the Factor VIII protein, as well as nucleic acid constructs encoding the Factor VIII proteins and methods of using these compositions to treat a bleeding disorder.

Abstract: The invention relates to synthetic liver-specific promoters and expression constructs for producing polypeptides and functional nucleic acids in the liver of a subject. The invention further relates to Factor VIII proteins containing modifications in the amino acid sequence of the Factor VIII protein, as well as nucleic acid constructs encoding the Factor VIII proteins and methods of using these compositions to treat a bleeding disorder.

Abstract: The technology of this application relates to a package substrate that includes a substrate body. Each unit region includes at least one solder ball group. The solder ball group includes a first solder ball, a second solder ball, a third solder ball, a fourth solder ball, a fifth solder ball, and a sixth solder ball that are arranged at spacings. The first solder ball, the second solder ball, the third solder ball, and the fourth solder ball are respectively located at four vertices of a parallelogram, and the second solder ball and the third solder ball each are adjacent to the first solder ball. The fifth solder ball is provided on a side of the parallelogram and is located between the first solder ball and the third solder ball. The sixth solder ball is provided on another side of the parallelogram and is located between the second solder ball and the fourth solder ball.

Abstract: A package substrate includes a substrate body and a plurality of unit regions disposed on the substrate body. The unit region includes two first solder ball structures. The first solder ball structure includes six first solder balls. The six first solder balls are arranged, with two of them in a row, to form three parallel rows of two solder balls: a first row of solder balls, a second row of solder balls, and a third row of solder balls. Four first solder balls in the first row of solder balls and the second row of solder balls are respectively located at four vertices of one parallelogram, and four first solder balls in the second row of solder balls and the third row of solder balls are respectively located at four vertices of the other parallelogram, and the two parallelograms are arranged axisymmetric about the second row of solder balls.

Abstract: A skin surface indwelling device for guiding punctures includes: an indwelling tube (13) having an inside tunnel (P) substantially extending along the longitudinal direction of the indwelling tube (13), the tunnel (P) is used for guiding needle (N), the indwelling tube (13) has a proximal end positioned above the skin surface (S) and a distal end positioned under the skin surface (S) in indwelling state; a support (11) having a bottom surface on its bottom that directly or indirectly contacts with the skin surface (S), the support (11) supports and fixates the indwelling tube (13); and a sealing elements (141,142) configured to seal the tunnel (P). The skin surface indwelling device for guiding punctures can shorten the time of establishing a puncture tunnel in the buttonhole puncture method, and help to build the puncture tunnel. In addition, the skin surface indwelling device can also guide the puncture needle (N) when puncturing, and protect the immature puncture tunnel.

Abstract: The invention relates to synthetic adeno-associated virus capsids targeted to the liver and vims vectors comprising the same. The invention further relates to methods of using the vectors to target the liver and provide liver-specific expression, as well as transduce human primary hepatocytes and cell lines.

Abstract: The invention relates to synthetic liver-specific promoters and expression constructs for producing polypeptides and functional nucleic acids in the liver of a subject. The invention further relates to Factor VIII proteins containing modifications in the amino acid sequence of the Factor VIII protein, as well as nucleic acid constructs encoding the Factor VIII proteins and methods of using these compositions to treat a bleeding disorder.

Abstract: The invention relates to synthetic liver-specific promoters and expression constructs for producing polypeptides and functional nucleic acids in the liver of a subject. The invention further relates to Factor VIII proteins containing modifications in the amino acid sequence of the Factor VIII protein, as well as nucleic acid constructs encoding the Factor VIII proteins and methods of using these compositions to treat a bleeding disorder.

Abstract: A skin surface indwelling device for guiding punctures includes: an indwelling tube (13) having an inside tunnel (P) substantially extending along the longitudinal direction of the indwelling tube (13), the tunnel (P) is used for guiding needle (N), the indwelling tube (13) has a proximal end positioned above the skin surface (S) and a distal end positioned under the skin surface (S) in indwelling state; a support (11) having a bottom surface on its bottom that directly or indirectly contacts with the skin surface (S), the support (11) supports and fixates the indwelling tube (13); and a sealing elements (141,142) configured to seal the tunnel (P). The skin surface indwelling device for guiding punctures can shorten the time of establishing a puncture tunnel in the buttonhole puncture method, and help to build the puncture tunnel. In addition, the skin surface indwelling device can also guide the puncture needle (N) when puncturing, and protect the immature puncture tunnel.

Abstract: The invention relates to synthetic liver-specific promoters and expression constructs for producing polypeptides and functional nucleic acids in the liver of a subject. The invention further relates to Factor VIII proteins containing modifications in the amino acid sequence of the Factor VIII protein, as well as nucleic acid constructs encoding the Factor VIII proteins and methods of using these compositions to treat a bleeding disorder.

Abstract: Disclosed herein is a composition of matter comprising a blend of discontinuous thermoplastic starch domains in a synthetic polymer, said composition of matter being characterized by an average diameter of thermoplastic starch domains of about 0.2 to about 1.5 microns. Also disclosed are compositions of matter comprising a blend of discontinuous thermoplastic starch domains in a synthetic polymer and being characterized by finished articles having key mechanical properties which are essentially maintained or in some cases improved over pure synthetic polymers. In yet another aspect, the present invention provides a method for making the material of the present invention. In a related aspect, the present invention provides the novel materials issued from the method of making the material. In other aspects, the present invention provides novel finished article compositions in the form of films or molded articles.

Abstract: The present invention relates to a highly controlled method of preparation of a microporous biodegradable polymeric article. Firstly, at least one biodegradable polymer A, one polymer B, biodegradable or not, partially or totally immiscible with A, and a compatibilizer C for A and B are selected. Secondly, the selected polymers are melt-blended, thereby preparing a polymer blend, wherein said polymers A and B have an essentially continuous morphology. Thirdly, after cooling, polymer B and compatibilizer C are selectively extracted from the polymer blend by dissolution in a solvent that is a non-solvent of polymer A. The resulting polymeric article has an essentially continuous porosity with a void volume between 10 and 90% and a unimodal diameter distribution set to a predefined unimodal peak location. It can be used in tissue engineering, for controlled release applications or as an implantable medical device.

Abstract: Disclosed herein is a composition of matter comprising a blend of discontinuous thermoplastic starch domains in a synthetic polymer, said composition of matter being characterized by an average diameter of thermoplastic starch domains of about 0.2 to about 1.5 microns. Also disclosed are compositions of matter comprising a blend of discontinuous thermoplastic starch domains in a synthetic polymer and being characterized by finished articles having key mechanical properties which are essentially maintained or in some cases improved over pure synthetic polymers. In yet another aspect, the present invention provides a method for making the material of the present invention. In a related aspect, the present invention provides the novel materials issued from the method of making the material. In other aspects, the present invention provides novel finished article compositions in the form of films or molded articles.

Abstract: The present invention relates to a highly controlled method of preparation of a microporous biodegradable polymeric article. Firstly, at least one biodegradable polymer A, one polymer B, biodegradable or not, partially or totally immiscible with A, and a compatibilizer C for A and B are selected. Secondly, the selected polymers are melt-blended, thereby preparing a polymer blend; wherein said polymers A and B have an essentially continuous morphology. Thirdly, after cooling, polymer B and compatibilizer C are selectively extracted from the polymer blend by dissolution in a solvent that is a non-solvent of polymer A. The resulting polymeric article has an essentially continuous porosity with a void volume between 10 and 90% and a unimodal diameter distribution set to a predefined unimodal peak location. It can be used in tissue engineering, for controlled release applications or as an implantable medical device.