Patents by Inventor Zhenlan DU

Zhenlan DU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inducible chimeric antigen receptor and application thereof
    Patent number: 12752007
    Abstract: An inducible chimeric antigen receptor and its application relate to the field of immune therapy. The inducible antigen receptor includes a single-chain variable fragment (scFv) antibody against human CSF1R, a truncated hIgG1 hinge region SH, a T cell co-stimulatory signaling molecule, and a T cell cytoplasmic signaling domain. Transcription of the chimeric antigen receptor is regulated by an inducible expression element tet operator. The induce chimeric antigen receptor molecules can be used to modify T lymphocytes, eliminating the cytokine storm problem of CAR-T cells in the treatment of Alzheimer's disease (AD), and achieving target treatment of AD.
    Type: Grant
    Filed: March 6, 2023
    Date of Patent: October 6, 2026
    Assignee: Beijing Tiantan Hospital, Capital Medical University
    Inventors: Jun Xu, Yanli Wang, Jiwei Jiang, Zhongli Du, Zhenlan Du
  • INDUCIBLE CHIMERIC ANTIGEN RECEPTOR AND APPLICATION THEREOF
    Publication number: 20240058445
    Abstract: An inducible chimeric antigen receptor and its application relate to the field of immune therapy. The inducible antigen receptor includes a single-chain variable fragment (scFv) antibody against human CSF1R, a truncated hIgG1 hinge region SH, a T cell co-stimulatory signaling molecule, and a T cell cytoplasmic signaling domain. Transcription of the chimeric antigen receptor is regulated by an inducible expression element tet operator. The induce chimeric antigen receptor molecules can be used to modify T lymphocytes, eliminating the cytokine storm problem of CAR-T cells in the treatment of Alzheimer's disease (AD), and achieving target treatment of AD.
    Type: Application
    Filed: March 6, 2023
    Publication date: February 22, 2024
    Inventors: Jun XU, Yanli WANG, Jiwei JIANG, Zhongli DU, Zhenlan DU