Abstract: Disclosed are a polyethylene glycol conjugate drug, and a preparation method therefor and the use thereof. Specifically, the present invention relates to a polyethylene glycol conjugate drug represented by formula A or a pharmaceutically acceptable salt thereof, a method for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, and the use of the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof in the preparation of a drug.

Abstract: The present disclosure relates to Alkynylphenylbenzamide compounds and the applications thereof. The said Alkynylphenylbenzamide compounds have the structure shown in Formula (I). The compounds can be used as protein kinase inhibitors, which can effectively inhibit the activity of TRK protein kinase and the proliferation, migration and invasion of various tumor cells. At the same time, it has the characteristics of good pharmacokinetics and low toxicity.

Abstract: A refrigerator production line and a method for upgrading a refrigerator software of an assembled refrigerator on the refrigerator production line are provided. The refrigerator production line includes a conveying device for conveying an assembled refrigerator; a scanning device for scanning and confirming an identification code of the assembled refrigerator and an address code of a communication module in the assembled refrigerator; and a local server for saving the identification code of the assembled refrigerator and the address code of the communication module and further acquiring, in response to a firmware upgrade request, a firmware upgrading package for the assembled refrigerator that corresponds to the identification code. After the assembled refrigerator is powered on, the communication module receives the firmware upgrade package, and a control module upgrades a public version software program according to the firmware upgrade package.

Abstract: A polyethylene glycol conjugate drug synergist, a preparation method therefor, and use thereof, specifically relating to a polyethylene glycol conjugate drug synergist as shown in formula I or a pharmaceutically acceptable salt thereof, a preparation method for the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylent glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, a composition containing the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof, and use of the polyethylene glycol conjugate drug synergist or the pharmaceutically acceptable salt thereof in preparation of a drug.

Abstract: The present disclosure relates to Alkynylphenylbenzamide compounds and the applications thereof. The said Alkynylphenylbenzamide compounds have the structure shown in Formula (I). The compounds can be used as protein kinase inhibitors, which can effectively inhibit the activity of TRK protein kinase and the proliferation, migration and invasion of various tumor cells. At the same time, it has the characteristics of good pharmacokinetics and low toxicity.

Abstract: An acid phosphatase mutant, and method for preparing nicotinamide riboside by same. The mutant is a protein of the following (a), (b) or (c): (a) a protein, having an amino acid sequence shown in SEQ ID NO: 3; (b) a protein, derived from (a), having catalytic activity higher than an acid phosphatase parent having an amino acid sequence shown in SEQ ID NO: 2, obtained by substituting, deleting or adding several amino acids in the amino acid sequence shown in SEQ ID NO: 3, using nicotinamide mononucleotide as a substrate; (c) a protein, having catalytic activity higher than the acid phosphatase shown in SEQ ID NO: 2, having 90% or more homology with the amino acid sequence of the protein defined by (a) or (b), and using nicotinamide mononucleotide as a substrate. It is used to prepare nicotinamide riboside and the conversion rate can be 99%.

Abstract: A refrigerator production line and a method for upgrading a refrigerator software of an assembled refrigerator on the refrigerator production line are provided. The refrigerator production line includes a conveying device for conveying an assembled refrigerator; a scanning device for scanning and confirming an identification code of the assembled refrigerator and an address code of a communication module in the assembled refrigerator; and a local server for saving the identification code of the assembled refrigerator and the address code of the communication module and further acquiring, in response to a firmware upgrade request, a firmware upgrading package for the assembled refrigerator that corresponds to the identification code. After the assembled refrigerator is powered on, the communication module receives the firmware upgrade package, and a control module upgrades a public version software program according to the firmware upgrade package.

Abstract: A nicotinamide riboside composition and preparation method thereof, the icotinamide riboside composition comprises nicotinamide riboside and/or a salt thereof and konjac glucomannan or rebaudioside A. The nicotinamide riboside composition provided by the present invention, used to increase the concentration of NAD in cells, thereby preventing and improving various unhealthy conditions caused by NAD deficiency. is stable in property and easy to store and transport.

Abstract: A nicotinamide riboside composition and preparation method thereof, the icotinamide riboside composition comprises nicotinamide riboside and/or a salt thereof and konjac glucomannan or rebaudioside A. The nicotinamide riboside composition provided by the present invention, used to increase the concentration of NAD in cells, thereby preventing and improving various unhealthy conditions caused by NAD deficiency. is stable in property and easy to store and transport.

Abstract: An acid phosphatase mutant, and method for preparing nicotinamide riboside by same. The mutant is a protein of the following (a), (b) or (c): (a) a protein, having an amino acid sequence shown in SEQ ID NO: 3; (b) a protein, derived from (a), having catalytic activity higher than an acid phosphatase parent having an amino acid sequence shown in SEQ ID NO: 2, obtained by substituting, deleting or adding several amino acids in the amino acid sequence shown in SEQ ID NO: 3, using nicotinamide mononucleotide as a substrate; (c) a protein, having catalytic activity higher than the acid phosphatase shown in SEQ ID NO: 2, having 90% or more homology with the amino acid sequence of the protein defined by (a) or (b), and using nicotinamide mononucleotide as a substrate. It is used to prepare nicotinamide riboside and the conversion rate can be 99%.

Abstract: The invention provides an aqueous enzyme slurry comprising enzyme particles, a water-soluble salt, and a natural polymeric viscosity regulating agent.

Abstract: The disclosure provides a simple and efficient method for producing a compound of Formula I.

Abstract: A pouch comprising a wall forming a chamber, the wall comprising a water-soluble polymer, and the chamber containing a particulate solid comprising an enzyme, and a liquid comprising a surfactant and/or a polyol. A method of preparing a pouch and a method of preparing an enzyme-containing detergent composition are disclosed.

Abstract: The present disclosure relates to the field of silica gel, and discloses a liquid optical silica gel composition, optical silica gel, a double-glazed photovoltaic assembly and a fabrication method of the optical silica gel. The present disclosure discloses a liquid optical silica gel composition. The composition contains vinyl silicone oil, hydrogen-containing silicone oil, hydrogen-containing MQ silicone resin, a catalyst, an inhibitor and a tackifier. The weight ratio between the vinyl silicone oil, the hydrogen-containing silicone oil, the hydrogen-containing MQ silicone resin and the tackifier is 1:(0.001-0.1):(0.0001-0.08):(0.001-0.05). The hydrogen-containing silicone oil contains first hydrogen-containing silicone oil and second hydrogen-containing silicone oil. The first hydrogen-containing silicone oil has a hydrogen content of 0.1 to 1 percent by weight. The second hydrogen-containing silicone oil has a hydrogen content of 0.01 to 0.1 percent by weight.

Abstract: The disclosure provides a simple and efficient method for producing a compound of Formula I.

Abstract: The present invention provides a cable TV broadband access system with distributed deployment and centralized control, which comprises: a system terminal end, configured to receive and transmit uplink and downlink service data, and receive and respond to access control data and management control data; a system access end, configured to implement data format transformation and data forwarding or processing for said uplink and downlink service data, said access control data and said management control data of said system terminal end, and transmit, receive and respond to management control data of said system access end; a system head end, configured to implement management control and access control for said system access end and said system terminal end, and process, converge and forward said uplink and downlink service data.

Abstract: The disclosure provides a process for the preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylate and its analogs. The process includes a reaction workup method for Claisen condensation, wherein the enolate salt is acidified after removing remaining starting material and byproducts such as, ethanol and excessive ethyl acetate. The process also includes a method for completely drying alkyl difluoroacetoacetate and its analogs before use in the next step by reacting trialkyl orthoformate with the residual water. The process includes using Na2CO3 and/or K2CO3 to promote the ring-closure reaction to produce the alkyl 3-di-fluoromethyl-1-methyl-1H-pyrazole-4- carboxylate. The process also includes effectively removing the regioisomer, alkyl 3-difluoro methyl-2-methyl-1H-pyrazole-4-carboxylate formed as a byproduct of the ring closure by a precipitation in a mixed solvent system and thereby eliminating the need for recrystallization of the final product.

Abstract: The disclosure provides a process for the preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-caboxylate and its analogs. The process includes a reaction workup method for Claisen condensation, wherein the enolate salt is acidified after removing remaining starting material and byproducts such as, ethanol and excessive ethyl acetate. The process also includes a method for completely drying alkyl difluoroacetoacetate and its analogs before use in the next step by reacting trialkyl orthoformate with the residual water. The process includes using Na2CO3 and/or K2CO3 to promote the ring-closure reaction to produce the alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylate. The process also includes effectively removing the regioisomer, alkyl 3-difluoromethyl-2-methyl-1H-pyrazole-4-caboxylate formed as a byproduct of the ring closure by a precipitation in a mixed solvent system and thereby eliminating the need for recrystallization of the final product.

Abstract: The disclosure provides a process for the preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylate and its analogs. The process includes a reaction workup method for Claisen condensation, wherein the enolate salt is acidified after removing remaining starting material and byproducts such as, ethanol and excessive ethyl acetate. The process also includes a method for completely drying alkyl difluoroacetoacetate and its analogs before use in the next step by reacting trialkyl orthoformate with the residual water. The process includes using Na2CO3 and/or K2CO3 to promote the ring-closure reaction to produce the alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylate. The process also includes effectively removing the regioisomer, alkyl 3-difluoromethyl-2-methyl-1H-pyrazole-4-carboxylate formed as a byproduct of the ring closure by a precipitation in a mixed solvent system and thereby eliminating the need for recrystallization of the final product.

Abstract: The present invention provides a cable TV broadband access system with distributed deployment and centralized control, which comprises: a system terminal end, configured to receive and transmit uplink and downlink service data, and receive and respond to access control data and management control data; a system access end, configured to implement data format transformation and data forwarding or processing for said uplink and downlink service data, said access control data and said management control data of said system terminal end, and transmit, receive and respond to management control data of said system access end; a system head end, configured to implement management control and access control for said system access end and said system terminal end, and process, converge and forward said uplink and downlink service data.