Patents by Inventor Zhenwei Miao

Zhenwei Miao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190091345
    Abstract: An anti-HER2 antibody-drug conjugate or a pharmaceutically acceptable salt thereof, and an application of the anti-HER2 antibody-drug conjugate for preparing an antitumor pharmaceutical product.
    Type: Application
    Filed: February 4, 2017
    Publication date: March 28, 2019
    Inventors: Zhenwei MIAO, Tong ZHU, B. Khasanov ALISHER, Gang CHEN, Zhaohui LI, Sheldon CAO
  • Publication number: 20190076438
    Abstract: The present invention provides an anti-ErbB2 antibody-drug conjugate, a composition comprising the conjugate, a method for preparing the conjugate, use of the conjugate.
    Type: Application
    Filed: November 22, 2016
    Publication date: March 14, 2019
    Applicant: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.
    Inventors: Tongtong XUE, Zhenwei MIAO, Jing WANG, Gang CHEN, Yan QING, Tong ZHU, Liang XIAO, Hong ZHANG, Qiuyan YANG, Dylan Dalun DENG, Liping LIU, Hong ZENG, Li YIN, Qifeng SHI, Hongmei SONG, Xi ZHAO, Lichun WANG, Jingyi WANG
  • Publication number: 20180243438
    Abstract: In one aspect, an active agent-conjugate, methods of preparing the active agent-conjugate, and uses thereof is provided.
    Type: Application
    Filed: December 26, 2017
    Publication date: August 30, 2018
    Applicant: Concortis Biosystems, Corp.
    Inventors: Zhenwei Miao, Yufeng Hong, Tong Zhu, Alexander Wilhelm Chucholowski
  • Patent number: 9981046
    Abstract: In one aspect, an active agent-conjugate, methods of preparing the active agent-conjugate, and uses thereof is provided.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: May 29, 2018
    Assignee: Concortis Biosystems, Corp., a wholly owned subsidiary of Sorrento Therapeutics, Inc.
    Inventors: Zhenwei Miao, Yufeng Hong, Tong Zhu
  • Publication number: 20180085471
    Abstract: In certain aspects, compounds and uses thereof are provided. In certain aspects, compound-conjugates and uses thereof are provided.
    Type: Application
    Filed: August 17, 2017
    Publication date: March 29, 2018
    Inventors: Zhenwei Miao, Yufeng Hong, Tong Zhu
  • Patent number: 9884127
    Abstract: In one aspect, an active agent-conjugate, methods of preparing the active agent-conjugate, and uses thereof is provided.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: February 6, 2018
    Assignee: Concortis Biosystems, Corp.
    Inventors: Zhenwei Miao, Yufeng Hong, Tong Zhu, Alexander Wilhelm Chucholowski
  • Patent number: 9801951
    Abstract: In certain aspects, compounds and uses thereof are provided. In certain aspects, compound-conjugates and uses thereof are provided.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: October 31, 2017
    Assignee: Concortis Biosystems, Corp.
    Inventors: Zhenwei Miao, Yufeng Hong, Tong Zhu
  • Patent number: 9796754
    Abstract: Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology use.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: October 24, 2017
    Assignee: Ambrx, Inc.
    Inventors: Zhenwei Miao, Kyle Atkinson, Sandra Biroc, Timothy Buss, Melissa Neal, Vadim Kraynov, Robin Marsden, Jason Pinkstaff, Lillian Skidmore, Ying Sun, Agnieszka Szydlik, Delia Ianina Lopez De Valenta
  • Publication number: 20170281758
    Abstract: There is disclosed a calicheamicin antibody drug conjugate comprising a linking amidoacetyl group covalently bound to a sugar moiety on calicheamicin or linking to sulfur atom on calicheamicin through disulfide bond.
    Type: Application
    Filed: March 29, 2017
    Publication date: October 5, 2017
    Inventors: Gang Chen, Alisher B. Khasanov, Hong Zhang, Tong Zhu, Zhenwei Miao
  • Publication number: 20170224835
    Abstract: There is disclosed antibody drug conjugates having anthracycline derivative drug moieties that provide improved safety and cell killing efficacy, wherein the anthracycline derivative drug moieties substitute an hydroxymethyl ketone moiety for an hydrazide or hydroxamate moiety. The disclosed cytotoxic agents (i.e., drug moieties) are conjugated to an antibody via either a Cys or a Lys residue. For Lys conjugation, the DAR (drug antibody ratio) of the majority of the ADC is 2 whereas the DAR of the majority of ADC is 4 when conjugation occurs on a Cys residue.
    Type: Application
    Filed: February 5, 2016
    Publication date: August 10, 2017
    Applicant: Sorrento Therapeutics, Inc.
    Inventors: Zhenwei Miao, Gang Chen, Tong Zhu, Alisher B. Khasanov, Dylan Deng, Hong Zhang, Zheng Yan
  • Publication number: 20170190736
    Abstract: There is disclosed a Dolastatin derivative, conjugated to an antibody, comprising a Dolastatin derivative moiety of Formula IV.
    Type: Application
    Filed: January 28, 2016
    Publication date: July 6, 2017
    Applicant: Sorrento Therapeutics, Inc.
    Inventors: Zhenwei Miao, Gang Chen, Tong Zhu, Alisher B. Khasanov, Dylan Deng, Hong Zhang
  • Patent number: 9637441
    Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid of Formula (I), and methods for making such non-natural amino acids and polypeptides.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: May 2, 2017
    Assignee: AMBRX, INC.
    Inventors: Zhenwei Miao, Junjie Liu, Thea Norman, Russell Driver
  • Patent number: 9586988
    Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: March 7, 2017
    Assignee: AMBRX, INC.
    Inventors: Zhenwei Miao, Junjie Liu, Thea Norman
  • Patent number: 9488660
    Abstract: Disclosed herein are methods of detecting non-natural amino acids and polypeptides that include at least one non-natural amino acid. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of functionalities, including but not limited to oxime, carbonyl, and/or hydroxylamine groups. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, and methods for detecting such polypeptides.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: November 8, 2016
    Assignee: AMBRX, INC.
    Inventors: Zhenwei Miao, Feng Tian, Anna-Maria A. Hays Putnam, Ying Buechler
  • Publication number: 20160067350
    Abstract: In one aspect, an active agent-conjugate, methods of preparing the active agent-conjugate, and uses thereof is provided.
    Type: Application
    Filed: May 14, 2013
    Publication date: March 10, 2016
    Applicant: Concortis Biosystems, Corp., a wholly owned subsidiary of Sorrento Therapeutics, Inc.
    Inventors: Zhenwei Miao, Yufeng Hong, Tong Zhu
  • Publication number: 20160052966
    Abstract: Disclosed herein are non-natural amino acids and dolastatin analogs that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The dolastatin analogs can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology use.
    Type: Application
    Filed: May 24, 2012
    Publication date: February 25, 2016
    Applicant: AMBRX, INC.
    Inventors: Zhenwei Miao, Kyle Atkinson, Sandra Biroc, Timothy Buss, Melissa Neal, Vadim Kraynov, Robin Marsden, Jason Pinkstaff, Lillian Skidmore, Ying Sun
  • Patent number: 9239324
    Abstract: The present invention provides compositions and methods for preparing protein drug conjugate and its application to stem cell therapy and treating cancer cells. The composition is an antibody-binding-therapeutic drug conjugate that binds antibodies targeted to cancer or stem cells. The method of using the composition includes the steps of combining an antibody that targets the cancer cells or stem cells with a sample for a time sufficient to allow said antibody to bind the targeted cells present in said sample and adding the antibody-binding-drug conjugate for a time sufficient to allow binding to the antibody bound to the targeted cells. The presence of the drug reduces the number of or eliminates the targeted cancer cells or stem cells. A similar method is disclosed for selecting antibodies that may be effective antibody drug conjugates.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: January 19, 2016
    Inventors: Gang Chen, Zhenwei Miao
  • Publication number: 20150299288
    Abstract: Modified insulin polypeptides and their uses thereof are provided
    Type: Application
    Filed: December 19, 2014
    Publication date: October 22, 2015
    Applicant: AMBRX, INC.
    Inventors: Zhenwei MIAO, Denise KRAWITZ, Vadim KRAYNOV, Tian FENG, Bee-Cheng SIM, Lillian SKIDMORE, Anna-Maria A. HAYS PUTNAM, Nick KNUDSEN, Michael DEGUZMAN
  • Publication number: 20150160192
    Abstract: The present invention provides compositions and methods for preparing protein drug conjugate and its application to stem cell therapy and treating cancer cells. The composition is an antibody-binding-therapeutic drug conjugate that binds antibodies targeted to cancer or stem cells. The method of using the composition includes the steps of combining an antibody that targets the cancer cells or stem cells with a sample for a time sufficient to allow said antibody to bind the targeted cells present in said sample and adding the antibody-binding-drug conjugate for a time sufficient to allow binding to the antibody bound to the targeted cells. The presence of the drug reduces the number of or eliminates the targeted cancer cells or stem cells. A similar method is disclosed for selecting antibodies that may be effective antibody drug conjugates.
    Type: Application
    Filed: December 6, 2013
    Publication date: June 11, 2015
    Inventors: Gang Chen, Zhenwei Miao
  • Publication number: 20150141646
    Abstract: In certain aspects, compounds and uses thereof are provided. In certain aspects, compound-conjugates and uses thereof are provided.
    Type: Application
    Filed: May 14, 2013
    Publication date: May 21, 2015
    Applicant: Concortis Biosystems, Corp., a wholly owned subsidary of Sorrento Therapeutics, Inc,
    Inventors: Zhenwei Miao, Yufeng Hong, Tong Zhu