Abstract: The present disclosure belongs to the field of steel materials, and relates to a steel wire rod for producing alloy tools with high fatigue life and high impact resistance and an application thereof. Chemical compositions of the steel include, by weight percentage: [C] 0.83%-0.92%, [Si] 2.30%-2.60%, [Mn] 0.40%-0.80%, [Cr] 0.70%-1.05%, [Ni] 1.31%-1.61%, [V] 0.14%-0.30%, [Al] 0.025%-0.060%, [P]?0.025%, [S]?0.020%, with the rest being Fe and unavoidable impurities. The alloy tool steel wire rod obtained in the present disclosure is suitable for producing screwdriver bits, screwdrivers, hex wrenches, etc., requiring high fatigue life and high impact resistance, and has the following properties: hardness within a range of 60-62 HRC, fatigue life of not less than 30,000 cycles, and impact resistance of not less than 60 seconds.

Abstract: The present disclosure belongs to the field of steel materials, and relates to a steel wire rod for producing alloy tools with high fatigue life and high impact resistance and an application thereof. Chemical compositions of the steel include, by weight percentage: [C] 0.83%-0.92%, [Si] 2.30%-2.60%, [Mn] 0.40%-0.80%, [Cr] 0.70%-1.05%, [Ni] 1.31%-1.61%, [V] 0.14%-0.30%, [Al] 0.025%-0.060%, [P]?0.025%, [S]?0.020%, with the rest being Fe and unavoidable impurities. The alloy tool steel wire rod obtained in the present disclosure is suitable for producing screwdriver bits, screwdrivers, hex wrenches, etc., requiring high fatigue life and high impact resistance, and has the following properties: hardness within a range of 60-62 HRC, fatigue life of not less than 30,000 cycles, and impact resistance of not less than 60 seconds.

Abstract: The present invention provides methods and compositions relating to an assay for hERG channel protein sensitivity to small molecule pharmacological agents. In one embodiment, the invention includes an engineered hERG channel protein. In another embodiment, the invention includes a method of identifying small molecule pharmacological agents that interfere with repolarization of cardiac cells.

Abstract: The present invention provides methods and compositions relating to an assay for hERG channel protein sensitivity to small molecule pharmacological agents. In one embodiment, the invention includes an engineered hERG channel protein. In another embodiment, the invention includes a method of identifying small molecule pharmacological agents that interfere with repolarization of cardiac cells.