Abstract: Provided herein are novel heterocyclic compounds, for example, compounds having Formula I. Also provided herein are methods of preparing the compounds and methods of using the same, for example, in inhibiting TGF-beta mediated signaling and/or for treating cancer.

Abstract: A system includes a focal plane array having multiple pixel circuit elements. Each pixel circuit element includes a photodetector configured to generate an electrical current based on received illumination. Each pixel circuit element also includes a capacitor configured to be charged by the electrical current and generate a voltage. Each pixel circuit element further includes a controller configured to sense whether the voltage on the capacitor exceeds a threshold during a sampling period. In addition, each pixel circuit element includes a timer configured to generate an estimate or measure of an amount of time within the sampling period during which the voltage on the capacitor does not exceed the threshold.

Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12C in a cell, and/or in treating various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (e.g., non-small cell lung cancer).

Abstract: A controller coupled to plural mobile devices through a mobile communications environment including multiple available networks at a location remote from the plural mobile devices. The plural mobile devices are simultaneously connected to plural networks and collecting network data for each simultaneously connected plural multiple networks. The controller includes a receiver receiving from each mobile device the collected network data, where each mobile device is connected to the receiver via an active one of the simultaneously connected plural multiple networks for transmitting the collected network data; a processor configured to evaluate the collected network data from each mobile device and, based upon respective rules established for each mobile device, to produce respective sets of operating parameters for the plural mobile devices; and a transmitter to transmit to each mobile device the respective sets of operating parameters.

Abstract: A controller and method of controlling a mobile device. The controller is coupled to a mobile device through a mobile communications environment. The controller is coupled to the mobile communications environment at a location remote from the mobile device, and includes a receiver that receives data from the mobile device, a processor that evaluates the data received from the mobile device based upon rules for the mobile device, and a transmitter that sends data to the mobile device to at least one of alert the user to a condition and modify current operating parameters on the mobile device.

Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I), Formula (A), Formula (II), Formula (III), Formula (IV), or Formula (V), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRASG12D in a cancer cell, and/or in treating various cancer such as pancreatic cancer, colorectal cancer, lung cancer (e.g., non-small cell lung cancer) or endometrial cancer.

Abstract: Provided herein are novel heterocyclic compounds, for example, compounds having Formula I. Also provided herein are methods of preparing the compounds and methods of using the same, for example, in inhibiting TGF-beta mediated signaling and/or for treating cancer.

Abstract: An environment-friendly construction waste treatment equipment for civil engineering is provided, including a main frame, a wringing frame, first fixing columns, a second fixing column, an electric motor, etc. wherein the first fixing column is provided on each of front and rear sides of a left side of an upper portion of the main frame, the wringing frame is provided between the first fixing columns, the second fixing column is provided on rear and left sides of the upper portion of the main frame, and the electric motor is provided on the second fixing column. The electric motor is turned on, the wringing wheels wring the construction waste, the wringed construction waste falls onto the conveying belt, and then is transferred to the filtering plate via the conveying belt. In this way, as the construction waste is conveyed via the conveying belt, the equipment is prevented from being blocked.

Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I), Formula (II), or Formula (III), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRASG12D in a cancer cell, and/or in treating various cancer such as pancreatic cancer, colorectal cancer, lung cancer or endometrial cancer.

Abstract: Provided herein are novel heterocyclic compounds, for example, compounds having Formula I. Also provided herein are methods of preparing the compounds and methods of using the same, for example, in inhibiting TGF-beta mediated signaling and/or for treating cancer.

Abstract: Provided herein are novel C-terminal Srk Kinase (CSK) inhibitors, e.g., having Formula G, I, II, or III. Also provided are methods of preparing the novel CSK inhibitors and method of using the novel CSK inhibitors for treating diseases or disorder such as cancer or for promoting immune response in a subject in need thereof.

Abstract: Provided herein are novel thyroid hormone receptor (TR) agonists e.g., having Formula I, II, or III. Also provided are methods of preparing the novel TR agonists and method of using the novel TR agonists for treating diseases or disorder modulated by TR agonists, such as NAFLD, NASH, diabetes, hyperlipidemia and/or hypercholesterolemia.

Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12C in a cell, and/or in treating various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (e.g., non-small cell lung cancer).

Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12C in a cell, and/or in treating various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (e.g., non-small cell lung cancer).

Abstract: Provided herein are novel heterocyclic compounds, for example, compounds having Formula I. Also provided herein are methods of preparing the compounds and methods of using the same, for example, in inhibiting TGF-beta mediated signaling and/or for treating cancer.

Abstract: A wireless network performance management system and method. The system includes at least one collection agent for collecting data related to at least one of service coverage; service quality; and usage of public and/or private data networks for enterprise clients, and a reporting unit to graphically represent the collected data to at least one of track, troubleshoot, and analyze the one of the service coverage; the service quality; and the usage of public and/or private data networks for the enterprise clients.

Abstract: The present invention reveals a new biasing method which can be used in solid state audio power amplifier design despite of the Class of operation. The proposed biasing technology relies only on traditional electrical feedback to build up and maintain the desired biasing current and doesn't need thermal coupling or thermal tracking techniques in order to overcome power transistor device's temperature dependent input-output characteristics as required by traditional approach. An ingenious current sensing and amplification circuit is devised in order to generate an voltage output which is only corresponding to the quiescent biasing current of the output stage. This voltage output is then used as an representative of the power stage biasing current to be regulated by a feedback loop comprising a traditional voltage multiplier, the output stage and the aforementioned current sensing and amplification circuit.

Abstract: The present invention reveals a new biasing method which can be used in solid state audio power amplifier design despite of the Class of operation. The proposed biasing technology relies only on traditional electrical feedback to build up and maintain the desired biasing current and doesn't need thermal coupling or thermal tracking techniques in order to overcome power transistor device's temperature dependent input-output characteristics as required by traditional approach. An ingenious current sensing and amplification circuit is devised in order to generate an voltage output which is only corresponding to the quiescent biasing current of the output stage. This voltage output is then used as an representative of the power stage biasing current to be regulated by a feedback loop comprising a traditional voltage multiplier, the output stage and the aforementioned current sensing and amplification circuit.

Abstract: Mobile user auditing system and method for monitoring at least one available network accessible by a mobile user within a mobile communications environment. The mobile user auditing system includes an acquisition device to acquire, from the mobile user, data related to at least one of: service coverage for the mobile user in the at least one available network; service quality for the mobile user in the at least one available network; and service usage for the mobile user in the at least one available network, and a plotter to identify on an audit map locations within the at least one available network from which the acquired data was received.