Abstract: A noise reduction device (100) for a respiratory apparatus (162) including a body (104) with a gas outlet (106) arranged to be mounted on the gas inlet (164) of the respiratory apparatus (162), and a cover (102) configured to be detachably engaged with the body (104) for forming a gas inlet (156) and a gas passage (138). The cover (102) includes a guiding member (136) to define at least a part of the gas passage (138) and the guiding member (136) is configured to be coupled with the body (104) to form the gas passage (138) between the body (104) and the cover (102). The noise reduction device (100) in the present invention provides a longer and smooth passage (138) for the gas to flow from the gas inlet (156) to the gas outlet (106) for reduction of turbulence and resistance of gas flow and hence reducing the noise caused by the friction between the fluctuated gas flow and the gas inlet (164) of the respiratory apparatus (162).

Abstract: A respiratory apparatus (100), comprising: a first gas inlet (202) for supplying a first gas to the respiratory apparatus (100); a second gas inlet (206) connectable to a pressurized gas source to supply a pressurized gas; a mixing chamber (204) for mixing the first gas and the pressurized gas; and a noise-damping member (216) disposed downstream of the mixing chamber (204).

Abstract: A heat plate for a humidifier contains a thermally conductive plate having a top surface and a bottom surface opposite the top surface. A temperature sensor is affixed to the bottom surface and a thermally conductive layer is directly-affixed to the bottom surface. A ceramic heating element is directly affixed to the thermally conductive layer. A humidifier and medical device may also contain such a heater plate.

Abstract: A liquid reservoir for a humidifier containing a base, a top portion opposite the base, a side wall, and a liquid presence indicator. The side wall contains a lower side wall portion adjacent to the base, and an upper side wall portion adjacent to the top portion. The liquid presence indicator interacts with the humidifier to detect the presence of liquid in the liquid reservoir. A humidifier, and/or a medical device may contain the liquid reservoir, and a method may employ the humidifier and/or medical device.

Abstract: A breathing circuit having a semipermeable membrane, an outer cage, and optionally an inner cage. The semipermeable membrane contains a poly(tetrafluoroethylene) membrane and a graphene anti-bacterial compound. The semipermeable membrane is affixed to the outer cage; optionally between the inner cage and the outer cage. Breathing circuits and breathing systems may contain such a cartridge.

Abstract: The present invention provides a humanized anti-TNF monoclonal antibody and the use thereof. The humanized anti-TNF monoclonal antibody significantly reduces the immunogenicity of murine-antibody while retaining the ability of antibody to recognize antigen, compared with conservative mouse chimeric antibody. Therefore, safety of the antibody in clinical applications has been improved.

Abstract: The present invention provides a humanized anti-TNF monoclonal antibody and the use thereof. The humanized anti-TNF monoclonal antibody significantly reduces the immunogenicity of murine-antibody while retaining the ability of antibody to recognize antigen, compared with conservative mouse chimeric antibody. Therefore, safety of the antibody in clinical applications has been improved.