Abstract: A flange integrated tuned mass damper, including a main shaft structure, a plurality of wire rope isolators, and a mass ring. Flange plates are installed on the main shaft structure, and the mass ring is located below and connected to the flange plates through the plurality of wire rope isolators uniformly distributed in a circumferential direction. The plurality of wire rope isolators are uniformly distributed outside the main shaft structure in the circumferential direction, and the wire rope isolators directly carries the mass ring and are in a tensile deformation state, with both spring and damper functions. The wire rope isolators can bear tensile, compressive, rolling, and shearing loads, thus ensuring the degree of freedom of the mass ring in any horizontal direction.

Abstract: A wave-direction-adaptive wave focusing type wave energy convertor with multiple water channels, comprising an energy acquisition system, an energy conversion system and a support system. Wave focusing is carried out through double water channels, so that the movement amplitude of water particles behind a box is doubled. A device is connected with a fixed pile through universal bearings, so that an opening of the device is always faced to a wave flow direction, which adapts to different seasons and water conditions, has low environmental requirements, and can be used in a wide sea area. Several coils of pretension spring compression are arranged in a winding barrel, so that a nylon rope connected to a buoy is ensured to be always in a straightened state and not derail from pulley blocks to work abnormally due to looseness whether the buoy is at a wave crest or a wave trough.

Abstract: A method for stabilizing fluorides and arsenic in soil includes: step 1, adding a calcium-containing compound to the soil contaminated by fluorides and arsenic, stirring uniformly, and standing for curing; step 2, adding an iron-containing compound to the mixture obtained in step 1, stirring uniformly, and standing for curing; and step 3, adding water to the mixture obtained in step 2, optionally adding a pH adjusting agent to adjust the gravimetric water content to 30%-40%, and standing for curing. The method uses calcium-containing and iron-containing compounds in a step-by-step manner, makes full use of the advantages of different passivation materials, combines the advantages of all reagents, and establishes an economical, efficient and environmentally friendly method for stabilizing fluorides and arsenic in soil to achieve effective remediation of contaminated soil.

Abstract: A method for stabilizing fluorides and arsenic in soil includes: step 1, adding a calcium-containing compound to the soil contaminated by fluorides and arsenic, stirring uniformly, and standing for curing; step 2, adding an iron-containing compound to the mixture obtained in step 1, stirring uniformly, and standing for curing; and step 3, adding water to the mixture obtained in step 2, optionally adding a pH adjusting agent to adjust the gravimetric water content to 30%-40%, and standing for curing. The method uses calcium-containing and iron-containing compounds in a step-by-step manner, makes full use of the advantages of different passivation materials, combines the advantages of all reagents, and establishes an economical, efficient and environmentally friendly method for stabilizing fluorides and arsenic in soil to achieve effective remediation of contaminated soil.

Abstract: A wave-direction-adaptive wave focusing type wave energy convertor with multiple water channels, comprising an energy acquisition system, an energy conversion system and a support system. Wave focusing is carried out through double water channels, so that the movement amplitude of water particles behind a box is doubled. A device is connected with a fixed pile through universal bearings, so that an opening of the device is always faced to a wave flow direction, which adapts to different seasons and water conditions, has low environmental requirements, and can be used in a wide sea area. Several coils of pretension spring compression are arranged in a winding barrel, so that a nylon rope connected to a buoy is ensured to be always in a straightened state and not derail from pulley blocks to work abnormally due to looseness whether the buoy is at a wave crest or a wave trough.

Abstract: The present invention provides methods, systems, and kits for evaluating the sensitivity and/or resistance of tumor specimens to one or a combination of chemotherapeutic agents. Particularly, the invention provides malignant cell gene signatures that are predictive of a tumor's response to candidate chemotherapeutic regimens.

Abstract: The present invention provides methods for preparing drug response and/or resistance profiles for breast tumor specimens, or cells derived therefrom. The drug response and/or resistance profiles are useful for determining effective chemotherapeutic agents for treatment of the tumor or cell to thereby individualize patient therapy. In other aspects, the invention provides a method for identifying a pathway or gene expression signature indicative of a breast cancer cell's sensitivity to a chemotherapeutic agent, which is useful for identifying a population response rate, or patient sub-population likely to respond to the drug candidate.

Abstract: The present invention provides methods for preparing a gene expression profile of a breast cancer cell, tumor, or cell line, where the gene expression profile may be evaluated for one or more gene expression signatures indicative of multidrug resistance. The signature may be indicative of resistance to one or more chemotherapeutic agents selected from a Taxol (e.g., Docetaxel or Paclitaxel), an antibiotic (e.g., Doxorubicin or Epirubicin), an antimetabolite (e.g., Fluorouracil and/or Gemcitabine), and an alkylating agent (e.g., Cyclophosphamide). Generally, the gene expression profile contains the level of expression for a plurality of genes listed in FIGS. 3, 4, and/or 5. Gene expression profiles for evaluating multidrug resistance for ER positive and ER negative breast cancers are also provided.

Abstract: The present invention provides methods, systems, and kits for evaluating the sensitivity and/or resistance of tumor specimens to one or a combination of chemotherapeutic agents. Particularly, the invention provides malignant cell gene signatures that are predictive of a tumor's response to candidate chemotherapeutic regimens.