Abstract: A method is described for building a numerical model. The method includes (a) defining a plurality of objective functions; (b) defining a plurality of parameters and obtaining a plurality of values for the plurality of parameters; (c) determining a plurality of simulation candidates from a plurality of iterations; and (d) filtering the plurality of simulation candidates from the plurality of iterations to select at least one numerical model for generating a prediction. For each iteration, the method includes: creating a plurality of proxies for each objective function and selecting a created proxy for each objective function, where at least one created proxy for each objective function includes a machine learning proxy, performing Monte Carlo sampling using the selected proxies and the defined plurality of parameters, and rejecting a subset of the created plurality of Monte Carlo samples responsive to the plurality of objective functions and acceptance criteria.

Abstract: The present disclosure provides compositions and methods related to engineered extracellular vesicles (EVs). In particular, the present disclosure provides a novel delivery platform for administering therapeutic agents to a subject using engineered EVs. As provided herein, EVs can be used to deliver biologically active cargo (e.g., mRNA, tumor antigens, small molecule drugs) to a subject to treat and/or prevent disease (e.g., viral infection, cancer, etc.).

Abstract: A method of calculating Water Movement from Child well to Parent well. The method includes obtaining hydraulic fracturing data; constructing a structured grid model using the obtained hydraulic fracturing data, where the structured grid model includes time-varying connectivity equivalent to the at least one parent well hydraulic fracture and the at least one child well hydraulic fracture to represent dynamically changing connectivity between wells and capture hydraulic fracturing growth; embedding fracture flow-based parameters into the structured grid model to generate a fine scale grid of permeability values; upscaling the fine scale grid of permeability values into a coarse scale grid of permeability values to determine a single connectivity value for each well pair; constructing a time varying connectivity curve for each well pair using the determined connectivity values for each well pair; and utilizing the time varying connectivity curve to calculate the Water Movement from Child well to Parent well.

Abstract: Provided is a camptothecin compound, which is a compound represented by structural formula I or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof. An antibody-drug conjugate comprising the camptothecin compound is also provided.

Abstract: A method for synthesizing 5,8-diamino-3,4-dihydro-2H-1-naphthalenone (Compound I), which method comprises: subjecting 2,5-diprotected aminophenylbutyric acid to the Friedel-Crafts reaction for ring closure, and then removing a protecting group on the amino group to obtain Compound I.

Abstract: This application provides a foreign object detection method and apparatus, and a wireless charging system. The foreign object detection apparatus includes a coil array and a foreign object detection circuit. The coil array includes at least one coil group, and each coil group includes four detection coils whose locations are symmetrical to each other. The foreign object detection circuit determine an abnormal-value threshold of each coil group based on induction signals of each coil group and that are obtained in a first time period, and detect, based on the abnormal-value threshold and the induction signals of each coil group, whether there is a foreign object; when it is determined that there is no foreign object, detect, based on the signal threshold of each coil group and induction signals that are of each coil group and that are obtained in a second time period, whether there is a foreign object.

Abstract: A pharmaceutical composition for the treatment of eczema is disclosed. Also disclosed are methods of treating eczema in a subject by administering a pharmaceutical composition.

Abstract: The present disclosure provides a display panel having a display area and including: a plurality of infrared emitting units and a plurality of infrared receiving units in the display area. The plurality of infrared emitting units are configured to emit infrared light to outside of the display panel, and the plurality of infrared receiving units are configured to receive the infrared light reflected by an object outside the display panel and output an electrical signal according to the received infrared light.

Abstract: A preparation method for a bis-substituted bridging antibody-drug conjugate, comprising: hydrolyzing an antibody coupling product obtained by coupling an antibody to a compound as represented by formula I. Also provided is an antibody coupling product obtained by the preparation method.

Abstract: Embodiments for generating a reservoir performance forecast are provided. The embodiments may be executed by a computer system. In one embodiment, a method includes obtaining inflow performance relationship data generated from a physics-based subsurface-surface coupled simulation model having a surface, a subsurface, and one or more wells fluidly connecting the subsurface to the surface. The inflow performance relationship data comprises performance data for at least one phase of fluid for each well. The method also includes generating a performance forecast for the reservoir using a subsurface simulator and a surface simulator. The subsurface simulator uses the inflow performance relationship data to represent the subsurface during generation of the performance forecast, and the performance forecast satisfies constraints solved by the surface simulator. In one embodiment, a method does not utilize a surface simulator.

Abstract: A method for evaluating adverse reaction of sesquiterpenoids in zedoary turmeric oil is performed successively according to the following steps: (1) preparing a hemoglobin (Hb) solution and a to-be-determined solution; (2) taking Hb solutions with a same volume and respectively adding the same volume of the to-be-determined solution or normal saline thereto, mixing well and standing; (3) determining absorbance with a microplate reader, and comparing the absorbance of a to-be-determined solution group with the absorbance of a normal saline group to obtain a value r; wherein if r>1.5, then the result indicates that the concentration of the to-be-determined solution has a risk of causing dyspnea; wherein, r = OD OD Hb ; in the formula, OD is an absorbance at 280 nm wavelength of the to-be-determined solution after interacting with Hb; ODHb, is an absorbance at 280 nm wavelength of a blank control of normal saline after interacting with Hb.

Abstract: A neural network, trained on a plurality of random size data samples, can receive a plurality of inference data samples including samples of different sizes. The neural network can generate feature maps of the plurality of inference data samples. Pooling can be utilized to generate feature maps having a fixed size. The fixed size feature maps can be utilized to generate an indication of a class for each of the plurality of inference data samples.

Abstract: This application provides a foreign object detection method and apparatus, and a wireless charging system. The foreign object detection apparatus includes a coil array and a foreign object detection circuit. The coil array includes at least one coil group, and each coil group includes four detection coils whose locations are symmetrical to each other. The foreign object detection circuit determine an abnormal-value threshold of each coil group based on induction signals of each coil group and that are obtained in a first time period, and detect, based on the abnormal-value threshold and the induction signals of each coil group, whether there is a foreign object; when it is determined that there is no foreign object, detect, based on the signal threshold of each coil group and induction signals that are of each coil group and that are obtained in a second time period, whether there is a foreign object.

Abstract: The present disclosure provides a display panel having a display area and including: a plurality of infrared emitting units and a plurality of infrared receiving units in the display area. The plurality of infrared emitting units are configured to emit infrared light to outside of the display panel, and the plurality of infrared receiving units are configured to receive the infrared light reflected by an object outside the display panel and output an electrical signal according to the received infrared light.

Abstract: The present disclosure relates to a system and method for machine learning from partial compressed representation. In some embodiments, an exemplary machine learning system includes: a compressor having circuitry configured to use a compression neural network to compress an image into a compressed representation, the compressed representation comprising a sequence of compressed channels; a selector having circuitry configured to select a part of the compressed channels from the compressed representation; and a learning module having circuitry configured to perform a learning task on the selected compressed channels.

Abstract: A neural network, trained on a plurality of random size data samples, can receive a plurality of inference data samples including samples of different sizes. The neural network can generate feature maps of the plurality of inference data samples. Pooling can be utilized to generate feature maps having a fixed size. The fixed size feature maps can be utilized to generate an indication of a class for each of the plurality of inference data samples.

Abstract: A single-fiber bidirectional optical transceiver subassembly, related to technology of optical communications, including an optical transmitting subassembly, an optical receiving subassembly and an optical splitting and filtering unit. The optical transmitting subassembly is coupled with an optical input port of the optical splitting and filtering unit. The optical receiving subassembly is coupled with an optical output port of the optical splitting and filtering unit. A bidirectional port of the optical splitting and filtering unit is coupled with a single-mode fiber. Each optical element in the optical transmitting subassembly, the optical receiving subassembly, and the optical splitting and filtering unit is a spatial optical element. Single-fiber bidirectional transmission is implemented with small channel spacing, by improving the optical splitting and filtering unit.

Abstract: A single-fiber bidirectional optical transceiver subassembly, related to technology of optical communications, including an optical transmitting subassembly, an optical receiving subassembly and an optical splitting and filtering unit. The optical transmitting subassembly is coupled with an optical input port of the optical splitting and filtering unit. The optical receiving subassembly is coupled with an optical output port of the optical splitting and filtering unit. A bidirectional port of the optical splitting and filtering unit is coupled with a single-mode fiber. Each optical element in the optical transmitting subassembly, the optical receiving subassembly, and the optical splitting and filtering unit is a spatial optical element. Single-fiber bidirectional transmission is implemented with small channel spacing, by improving the optical splitting and filtering unit.

Abstract: A system, method and computer-readable medium for testing a service-based application identifies a set of use cases for the service-based application. Each use case in the set is mapped to a test case to generate a first set of test cases. Each of the test cases is refined to generate an updated set of test cases and the updated set of test cases is executed.