Patents by Inventor Zhi-Cheng Xiao

Zhi-Cheng Xiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nogo, Caspr, F3 NB-3 useful in the treatment of injury and disease to the central nervous system
    Patent number: 8273855
    Abstract: The application provides materials and methods for promoting myelination of neuronal axons in the CNS. These derive from the findings first that the molecules Nogo and Caspr interact with one another during establishment and maintenance of the axoglial junction, and secondly that the molecules F3 and NB-3 are capable of promoting oligodendrocyte maturation via interaction with Notch. The materials and methods provided may be used in the treatment of CNS damage, in particular the treatment of spinal cord injury, multiple sclerosis, epilepsy and stroke.
    Type: Grant
    Filed: June 25, 2007
    Date of Patent: September 25, 2012
    Assignee: Jiangsu Novavac Bio-Tec Co., Ltd.
    Inventor: Zhi-Cheng Xiao
  • Materials and methods relating to treatment of injury and disease to the central nervous system
    Publication number: 20100015099
    Abstract: The application provides materials and methods for promoting myelination of neuronal axons in the CNS. These derive from the findings first that the molecules Nogo and Caspr interact with one another during establishment and maintenance of the axoglial junction, and secondly that the molecules F3 and NB-3 are capable of promoting oligodendrocyte maturation via interaction with Notch. The materials and methods provided may be used in the treatment of CNS damage, in particular the treatment of spinal cord injury, multiple sclerosis, epilepsy and stroke.
    Type: Application
    Filed: June 25, 2007
    Publication date: January 21, 2010
    Inventor: Zhi-Cheng Xiao
  • Peptides, antibodies thereto, and their use in treatment of central nervous system, damage
    Patent number: 7408028
    Abstract: The application provides peptides that interact with the inhibitory domains of the myelin proteins Nogo, TNR, and MAG. These may be used in the treatment of CNS damage, and for the development of further treatments. Also provided are methods and materials for immunizing subjects against the inhibitory domains of the myelin proteins, for the treatment of CNS damage.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: August 5, 2008
    Assignee: Sinapore General Hospital Pte Ltd.
    Inventor: Zhi-Cheng Xiao
  • Central nervous system damage
    Publication number: 20060205668
    Abstract: The application provides peptides that interact with the inhibitory domains of the myelin proteins Nogo, TNR, and MAG. These may be used in the treatment of CNS damage, and for the development of further treatments. Also provided are methods and materials for immunizing subjects against the inhibitory domains of the myelin proteins, for the treatment of CNS damage.
    Type: Application
    Filed: December 5, 2003
    Publication date: September 14, 2006
    Inventor: Zhi-Cheng Xiao
  • Nogo, caspr, f3 nb-3 useful in the treatment of injury and disease to the central nervous system
    Publication number: 20060122110
    Abstract: The application provides materials and methods for promoting myelination of neuronal axons in the CNS. These derive from the findings firstly that the molecules Nogo and Caspr interact with one another during establishment and maintenance of the axoglial junction, and secondly that the molecules F3 and NB-3 are capable of promoting oligodendrocyte maturation via interaction with Notch. The materials and methods provided may be used in the treatment of CNS damage, in particular the treatment of spinal cord injury, multiple sclerosis, epilepsy and stroke.
    Type: Application
    Filed: December 5, 2003
    Publication date: June 8, 2006
    Inventor: Zhi-Cheng Xiao