Patents by Inventor Zhi-Fu Tao

Zhi-Fu Tao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
    Publication number: 20100184750
    Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
    Type: Application
    Filed: January 18, 2010
    Publication date: July 22, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Laura A. Hexamer, Hong Ding, Steven W. Elmore, Aaron R. Kunzer, Xiaohong Song, Andrew J. Souers, Gerard M. Sullivan, Zhi-Fu Tao, Michael D. Wendt
  • APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
    Publication number: 20100160322
    Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
    Type: Application
    Filed: December 4, 2009
    Publication date: June 24, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Milan Bruncko, Yujia Dai, Hong Ding, George A. Doherty, Steven W. Elmore, Lisa Hasvold, Laura Hexamer, Aaron Kunzer, Robert A. Mantei, William J. McClellan, Chang H. Park, Cheol-Min Park, Andrew M. Petros, Xiaohong Song, Andrew J. Souers, Gerard M. Sullivan, Zhi-Fu Tao, Gary T. Wang, Le Wang, Xilu Wang, Michael D. Wendt
  • BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES
    Publication number: 20100152183
    Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
    Type: Application
    Filed: December 4, 2009
    Publication date: June 17, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Milan Bruncko, Hong Ding, George A. Doherty, Steven W. Elmore, Lisa Hasvold, Laura Hexamer, Aaron Kunzer, Robert A. Mantei, William J. McClellan, Chang H. Park, Cheol-Min Park, Andrew M. Petros, Xiaohong Song, Andrew J. Souers, Gerard M. Sullivan, Zhi-Fu Tao, Gary T. Wang, Le Wang, Xilu Wang, Michael D. Wendt
  • 7-NONSUBSTITUTED INDOLE MCL-1 INHIBITORS
    Publication number: 20090124616
    Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
    Type: Application
    Filed: April 16, 2008
    Publication date: May 14, 2009
    Applicant: Abbott Laboratories
    Inventors: Xiaohong Song, Hong Ding, Steven W. Elmore, Milan Bruncko, David J. Madar, Andrew J. Souers, Cheol-Min Park, Zhi-Fu Tao, Xilu Wang, Aaron R. Kunzer
  • 7-SUBSTITUTED INDOLE MCL-1 INHIBITORS
    Publication number: 20090054402
    Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
    Type: Application
    Filed: April 16, 2008
    Publication date: February 26, 2009
    Applicant: Abbott Laboratories
    Inventors: Xilu Wang, Xiaohong Song, Steven W. Elmore, Milan Bruncko, David J. Madar, Andrew J. Souers, Lisa A. Hasvold, Le Wang, Zhi-Fu Tao, Aaron R. Kunzer
  • PIM KINASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS
    Publication number: 20090030196
    Abstract: Inhibitors of Pim kinases, ways to make them and methods of treating patients using them are disclosed.
    Type: Application
    Filed: June 5, 2008
    Publication date: January 29, 2009
    Applicant: Abbott Laboratories
    Inventors: Le Wang, Lisa A. Hasvold, Zhi-Fu Tao, Laura Hexamer, Thomas D. Penning
  • PIM KINASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS
    Publication number: 20080161559
    Abstract: Inhibitors of Pim kinases, ways to make them and methods of treating patients using them are disclosed.
    Type: Application
    Filed: December 6, 2007
    Publication date: July 3, 2008
    Applicant: ABBOTT LABORATORIES
    Inventors: Thomas D. Penning, Lisa A. Hasvold, Laura A. Hexamer, Vincent L. Giranda, Nan-horng Lin, Zhi-Fu Tao, Le Wang
  • Fused tri and tetra-cyclic pyrazole kinase inhibitors
    Patent number: 7320986
    Abstract: Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: January 22, 2008
    Assignee: Abbott Labortories
    Inventors: Yunsong Tong, Akiyo K. Claiborne, Gaoquan Li, Nan-Horng Lin, Hing L. Sham, Thomas J. Sowin, Zhi-Fu Tao
  • INHIBITORS OF POLO-LIKE KINASES
    Publication number: 20080015192
    Abstract: Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Application
    Filed: May 24, 2007
    Publication date: January 17, 2008
    Inventors: Robert Diebold, Stevan Djuric, Vincent Giranda, Laura Hexamer, Nan-Horng Lin, Julie Miyashiro, Thomas Penning, Magdalena Przytulinska, Thomas Sowin, Gerard Sullivan, Zhi-Fu Tao, Yunsong Tong, Anil Vasudevan, Le Wang, Keith Woods, Zhiren Xia, Henry Zhang
  • Macrocyclic kinase inhibitors
    Patent number: 7163939
    Abstract: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: January 16, 2007
    Assignee: Abbott Laboratories
    Inventors: Nan-Horng Lin, Gaoquan Li, Magdalena K. Przytulinska, Thomas J. Sowin, Gerard M. Sullivan, Zhi-Fu Tao, Yunsong Tong, Le Wang
  • Macrocyclic kinase inhibitors
    Publication number: 20050215556
    Abstract: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Application
    Filed: November 3, 2004
    Publication date: September 29, 2005
    Inventors: Nan-Horng Lin, Gaoquan Li, Magdalenna Przytulinska, Thomas Sowin, Gerard Sullivan, Zhi-Fu Tao, Yunsong Tong, Le Wang
  • Macrocyclic kinase inhibitors
    Publication number: 20050096324
    Abstract: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Application
    Filed: November 5, 2003
    Publication date: May 5, 2005
    Inventors: Zhi-Fu Tao, Nan-Horng Lin, Le Wang, Thomas Sowin
  • Fused tri and tetra-cyclic pyrazole kinase inhibitors
    Publication number: 20040259904
    Abstract: Compounds having the formula (I) 1
    Type: Application
    Filed: March 3, 2004
    Publication date: December 23, 2004
    Inventors: Yunsong Tong, Akiyo K. Claiborne, Gaoquan Li, Nan-Horng Lin, Hing L. Sham, Thomas J. Sowin, Zhi-Fu Tao
  • Compounds capable of cleaving double-stranded DNA and method of utilization of the same
    Patent number: 6713633
    Abstract: Novel chemical species capable of simultaneously alkylating double-stranded DNA and cleaving the same; methods for alkylating and cleaving DNA by using these species; and anticancer agents with the use of these compounds. Compounds represented by the following general formula (I) which are capable of simultaneously alkylating double-stranded DNA and cleaving the same; a method for alkylating DNA and a method for cleaving double stranded DNA by using these compounds; and medicinal compositions with the use of these compounds: B—L—A(I) wherein B represents a chemical structure capable of recognizing the base sequence of DNA, for example, optionally substituted pyrrole-imidazole polyamide; A represents a chemical structure capable of binding to one base of DNA, for example, the alkylation moiety of duocarmycin A; and L represents a linker capable of binding the chemical structures A and B, for example, vinyl.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: March 30, 2004
    Assignee: Japan Science and Technology Corporation
    Inventors: Hiroshi Sugiyama, Zhi-Fu Tao, Isao Saito
  • Compounds alkylating specific base sequence of DNA and method for synthesizing the same
    Patent number: 6566336
    Abstract: The invention provides a compound recognizing the minor group of hydrogen bonds between base pairs and being capable of forming a covalent bond with bases. The inventive compound can recognize a specific nucleotide sequence and can strongly bind to adjacent bases via covalent bonding, to regulate the expression of a DNA with the nucleotide sequence. The invention provides a DNA alkylating agent comprising a compound represented by the general formula I: wherein R represents a lower amyl group or a polyamide group; and X represents nitrogen or CH.
    Type: Grant
    Filed: May 30, 2000
    Date of Patent: May 20, 2003
    Assignee: Japan Science and Technology Corporation
    Inventors: Hiroshi Sugiyama, Zhi Fu Tao, Isao Saito