Patents by Inventor ZhiGang Cai

ZhiGang Cai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11766211
    Abstract: The present invention provides a uterus OCT catheter, comprising: a catheter body; the catheter body comprises an outer sleeve, an OCT imaging catheter and a Luer connector; the outer sleeve is provided with an exit window; the reflecting surface of the reflecting prism in the OCT imaging catheter faces the exit window. The present invention further provides a uterus OCT equipment with pull-back function, comprising a pull-back device and the catheter body, the pull-back device comprises a first housing, a driving connector, a fixing sleeve and a catheter fixing tube. The invention adopts the way that the outer sleeve wraps the OCT imaging catheter to increase the overall strength and diameter; a pull-back device is adopted, the pull-back process is stable and in uniform speed, and can effectively prevent complications during human operation and damage to human tissue during pull-back process.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: September 26, 2023
    Assignee: GUANGZHOU WINSTAR MEDICAL TECHNOLOGY COMPANY LIMITED
    Inventors: Liyan Song, Weiliang Liang, Jiangfan Pan, Bailing Li, Jun Gao, Zhigang Cai
  • Publication number: 20230272442
    Abstract: The present invention provides a 5-methylfolate producing microorganism which a) has been modified to have a decreased expression and/or activity of a polypeptide having both dihydrofolate synthase activity and folylpolyglutamate synthetase activity compared to an otherwise identical microorganism (reference microorganism); b) has been (further) modified to express a heterologous polypeptide having only dihydrofolate synthase activity; c) has been (further) modified to have an increased expression level of at least one enzyme (such as at least two, at least three, at least four, at least five, at least six, at least seven or at least eight) enzymes involved in the biosynthesis of a 5-methylfolate compared to an otherwise identical microorganism (reference microorganism); and/or d) has been (further) modified to have a decreased expression and/or activity of a polypeptide having 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity compared to an otherwise identical microorganism (ref
    Type: Application
    Filed: June 30, 2021
    Publication date: August 31, 2023
    Inventors: Mingan Shi, Xin Xiong, Jia Sun, Jing Zuo, Yunchong Xia, Zailing Zhu, Zhigang Cai, Guoying Zhang, Marko Blazlc, Tina Kogej, Gregor Kosec, Mirjan Svageij, Jaka Horvat, Stefan Fujs
  • Publication number: 20220282207
    Abstract: Provided is a folate producing strain and the preparation and application thereof, in particular, the expression level of the endogenous folC gene in the engineered strain of the present invention is decreased, and the exogenous folC gene is introduced, and the production capacity of the folate, the precursor, or the intermediate thereof in the engineered strain is significantly improved compared to the starting strain.
    Type: Application
    Filed: May 13, 2020
    Publication date: September 8, 2022
    Inventors: Ming'An SHI, Jia SUN, Xiangyu SUN, Fei SHAO, Zhigang CAI, Guoyin ZHANG, Marko BLAZIC, Tina KOGEJ, Gregor KOSEC, Stefan FUJS, Alen CUSAK, Jaka HORVAT
  • Patent number: 11219369
    Abstract: The invention discloses an OCT probe used for human open lumen system, comprising a probe protector, a probe body, an oily liquid, a metal coil, a probe guard tip and a light-guided optical fiber; the probe body is match mounted will the metal coil, and the metal coil is mounted on the rear end of the probe body; the light-guided optical fiber is fixed inside the probe body; the probe guard tip is sleeved on the probe body, the probe protector is sleeved on the probe guard tip and sleeved on the metal coil; the oily liquid is filled between the probe guard tip and the probe protector, and between the metal coil and the probe protector. The invention effectively remedy for the defect that the image is unclear by filling the oily liquid between the probe protector and the probe body.
    Type: Grant
    Filed: March 23, 2019
    Date of Patent: January 11, 2022
    Assignee: GUANGZHOU WINSTAR MEDICAL TECHNOLOGY COMPANY LIMITED
    Inventors: Zhigang Cai, Guanyue Kong, Jun Gao, Hongjian Ma, Ziyi Chen, Jiaoyang Li, Bailing Li
  • Publication number: 20200367752
    Abstract: The present invention provides an OCT catheter for the respiratory tract. An optical fiber connecting part is connected to an optical fiber, a guide wire assembly is sleeved outside the optical fiber connected to an optical fiber interface, an end of the guide wire assembly is sleeved inside the optical fiber interface connected to an optical fiber coupler, the optical fiber coupler is sleeved inside a connector sleeved inside a fixing head, an end of the fixing head is sleeved inside a sealing assembly, and the guide wire assembly sequentially passes through the connector, the fixing head and the sealing assembly. The OCT catheter is connected to the SC-type optical fiber interface through the SC-SC optical fiber coupler of a driving module. By adopting a guide wire with a small diameter, the medical OCT catheter can be applied to higher-generation bronchi, thereby expanding the application range.
    Type: Application
    Filed: August 10, 2020
    Publication date: November 26, 2020
    Inventors: Liyan SONG, Bailing LI, Weiliang LIANG, Jun GAO, Zhigang CAI, Jiaoyang LI
  • Publication number: 20200305724
    Abstract: The present invention provides a uterus OCT catheter, comprising: a catheter body; the catheter body comprises an outer sleeve, an OCT imaging catheter and a Luer connector; the outer sleeve is provided with an exit window; the reflecting surface of the reflecting prism in the OCT imaging catheter faces the exit window. The present invention further provides a uterus OCT equipment with pull-back function, comprising a pull-back device and the catheter body, the pull-back device comprises a first housing, a driving connector, a fixing sleeve and a catheter fixing tube. The invention adopts the way that the outer sleeve wraps the OCT imaging catheter to increase the overall strength and diameter; a pull-back device is adopted, the pull-back process is stable and in uniform speed, and can effectively prevent complications during human operation and damage to human tissue during pull-back process.
    Type: Application
    Filed: November 3, 2017
    Publication date: October 1, 2020
    Inventors: LIYAN SONG, WEILIANG LIANG, JIANGFAN PAN, BAILING LI, JUN GAO, ZHIGANG CAI
  • Publication number: 20190216324
    Abstract: The invention discloses an OCT probe used for human open lumen system, comprising a probe protector, a probe body, an oily liquid, a metal coil, a probe guard tip and a light-guided optical fiber; the probe body is match mounted will the metal coil, and the metal coil is mounted on the rear end of the probe body; the light-guided optical fiber is fixed inside the probe body; the probe guard tip is sleeved on the probe body, the probe protector is sleeved on the probe guard tip and sleeved on the metal coil; the oily liquid is filled between the probe guard tip and the probe protector, and between the metal coil and the probe protector. The invention effectively remedy for the defect that the image is unclear by filling the oily liquid between the probe protector and the probe body.
    Type: Application
    Filed: March 23, 2019
    Publication date: July 18, 2019
    Inventors: Zhigang Cai, Guanyue Kong, Jun Gao, Hongjian Ma, Ziyi Chen, Jiaoyang Li, Bailing Li
  • Patent number: 6722924
    Abstract: A cable connector assembly (1) includes a housing (10), a pair of first electrical connectors (20), a pair of second electrical connectors (30), a shielding member (40), a pair of first cables (50) and a second cable (50). The housing has an elongate base (103). The base has a mating face (105) and a rear face (106) opposite to the mating face. The base defines a pair of first cavities (101) and a pair of second cavities (102) arranged side by side and extending inwardly from the mating face. The first cables and the second cable respectively electrically and mechanically connects with the first electrical connectors and the second electrical connectors and extend beyond the rear face for being mounted on a mother board of an electronic apparatus. The shielding member is assembled on the housing. The cable connector assembly can be fastened on a panel of the electronic apparatus for providing input/output ports.
    Type: Grant
    Filed: December 24, 2002
    Date of Patent: April 20, 2004
    Assignee: Hon Hai Precision Ind. Co., Ltd.
    Inventors: Hong Bin Zhou, Zhigang Cai
  • Patent number: D501828
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: February 15, 2005
    Assignee: Hon Hai Precision Ind. Co., Ltd.
    Inventors: Hongbin Zhou, ZhiGang Cai, Yao Jun Wang