Patents by Inventor Zhi-Hui Lu

Zhi-Hui Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8975447
    Abstract: Disclosed are a process and catalysts useful for carrying out asymmetric methlyallylations. The catalysts used in the invention have the formula (IV): wherein X1, X2, R3 and R4 are as defined herein. Compounds made by the process of the invention can be used to prepare pharmaceutically active compounds such as 11-?-hydroxysteroid hydrogenase type 1 (11-?-HSD1) inhibitors including 1,3-disubstituted oxazinan-2-ones.
    Type: Grant
    Filed: March 6, 2012
    Date of Patent: March 10, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Wenjie Li, Zhi-Hui Lu, Chris Hugh Senanayake, Yongda Zhang
  • Patent number: 8916701
    Abstract: Disclosed is a process for making diastereomeric compound of the formula (I): wherein m, n and R1 to R4 are as defined herein. The process of the invention provides the compound of formula (I) in high yield and substantially free of the corresponding diastereomers. The compounds of formula (I) prepared by the process of the invention are useful for making pharmaceutically active compounds such as 11-?-hydroxysteroid hydrogenase type 1 (11-?-HSD1) inhibitors.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: December 23, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Daniel Robert Fandrick, Zhi-Hui Lu, Diana Reeves, Jonathan Reeves, Chris Hugh Senanayake, Jinhua Jeff Song, Yongda Zhang
  • Publication number: 20140171692
    Abstract: Disclosed are a process and catalysts useful for carrying out asymmetric methlyallylations. The catalysts used in the invention have the formula (IV): wherein X1, X2, R3 and R4 are as defined herein. Compounds made by the process of the invention can be used to prepare pharmaceutically active compounds such as 11-?-hydroxysteroid hydrogenase type 1 (11-?-HSD1) inhibitors including 1,3-disubstituted oxazinan-2-ones.
    Type: Application
    Filed: March 6, 2012
    Publication date: June 19, 2014
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Wenjie Li, Zhi-Hui Lu, Chris Hugh Senanayake, Yongda Zhang
  • Publication number: 20140135493
    Abstract: Disclosed is a process for making diastereomeric compound of the formula (I): wherein m, n and R1 to R4 are as defined herein. The process of the invention provides the compound of formula (I) in high yield and substantially free of the corresponding diastereomers. The compounds of formula (I) prepared by the process of the invention are useful for making pharmaceutically active compounds such as 11-?-hydroxysteroid hydrogenase type 1 (11-?-HSD1) inhibitors.
    Type: Application
    Filed: December 15, 2011
    Publication date: May 15, 2014
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Daniel Robert Fandrick, Zhi-Hui Lu, Diana Crimhilda Reeves, Jonathan Timothy Reeves, Chris Hugh Senanayake, Jinhua J. Song, Yongda Zhang
  • Publication number: 20140094609
    Abstract: The present invention is directed to an improved process for the preparation of Compounds of Formula (I), which are useful in the treatment of HIV infection. In particular, the present invention is directed to an improved process for the preparation of (2S)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid, which is useful in the treatment of HIV infection.
    Type: Application
    Filed: October 2, 2013
    Publication date: April 3, 2014
    Inventors: Brandon H. Brown, Xiang Wang, Keith R. Fandrick, Joe Ju Gao, Nizar Haddad, Serge R. Landry, Wenjie Li, Zhi-Hui Lu, Bo Qu, Diana C. Reeves, Carl Thibeault, Yongda Zhang
  • Publication number: 20140094610
    Abstract: The present invention is directed to an improved process for the preparation of Compounds of Formula (I) or salts thereof which are useful in the treatment of HIV infection. In particular, the present invention is directed to an improved process for the preparation of (2S)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid or salt thereof which is useful in the treatment of HIV infection.
    Type: Application
    Filed: October 3, 2013
    Publication date: April 3, 2014
    Inventors: Wenjie LI, Philomen DECROOS, Keith R. FANDRICK, Joe Ju GAO, Nizar HADDAD, Zhi-Hui LU, Bo QU, Sonia RODRIGUEZ, Chris H. SENANAYAKE, Yongda ZHANG, Wenjun TANG
  • Publication number: 20140057928
    Abstract: This invention relates to novel sodium salt forms of the following Compound (1), and methods for the preparation thereof, pharmaceutical compositions thereof, and their use in the treatment of Hepatitis C Viral (HCV) infection:
    Type: Application
    Filed: October 30, 2013
    Publication date: February 27, 2014
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Rolf-Stefan BRICKL, Shirlynn CHEN, Jihchin CHUNG, Mayur Suryakant DUDHEDIA, Danping LI, Zhi-Hui LU, Siddharthya MUJUMDAR, Chitra TELANG, Richard J. VARSOLONA, Zeren WANG
  • Patent number: 8598183
    Abstract: This invention relates to novel sodium salt forms of the following Compound (1), and methods for the preparation thereof, pharmaceutical compositions thereof, and their use in the treatment of Hepatitis C Viral (HCV) infection:
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: December 3, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Rolf-Stefan Brickl, Shirlynn Chen, Jihchin Chung, Mayur Suryakant Dudhedia, Danping Li, Zhi-Hui Lu, Siddharthya Mujumdar, Chitra Telang, Richard J. Varsolona, Zeren Wang
  • Patent number: 8487094
    Abstract: Disclosed are syntheses of 11?-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: July 16, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Keith R. Fandrick, Joe Ju Gao, Wenjie Li, Zhi-Hui Lu, Yongda Zhang
  • Publication number: 20120122887
    Abstract: This invention relates to novel sodium salt forms of the following Compound (1), and methods for the preparation thereof, pharmaceutical compositions thereof, and their use in the treatment of Hepatitis C Viral (HCV) infection:
    Type: Application
    Filed: September 23, 2011
    Publication date: May 17, 2012
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Rolf-Stefan BRICKL, Shirlynn CHEN, Jihchin CHUNG, Mayur Suryakant DUDHEDIA, Danping LI, Zhi-Hui LU, Siddharthya MUJUMDAR, Chitra TELANG, Richard J. VARSOLONA, Zeren WANG
  • Publication number: 20110269957
    Abstract: Disclosed are syntheses of 11?-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).
    Type: Application
    Filed: July 23, 2009
    Publication date: November 3, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Keith R. Fandrick, Joe Ju Gao, Wenjie Li, Zhi-Hui Lu, Yongda Zhang
  • Patent number: 7851625
    Abstract: Disclosed are processes for making 2, 3 disubstituted indole compounds such as compounds of general formula I comprised of the steps of a) reacting a bromoindole compound (i) with a dialkoxyl C1-5 borane in the presence of a ligand, a palladium catalyst and a base to make a compound of general formula (ii); or alternatively reacting compound (i) with a trialkyl magnesiate reagent, followed by treatment with a borate; b) reacting the product of step a with a R2-Hal where R2-Hal is defined herein.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: December 14, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Ahmad Khodabocus, Zhi-Hui Lu, Chris Hugh Senanayake, Hanxun Wei, Yongda Zhang
  • Patent number: 7642352
    Abstract: Disclosed are processes for making 2,3 disubstituted indole compounds such as compounds of general formula I comprised of the steps of a) reacting a bromoindole compound (i) with a dialkoxyl C1-5 borane in the presence of a ligand, a palladium catalyst and a base to make a compound of general formula (ii); or alternatively reacting compound (i) with a trialkyl magnesiate reagent, followed by treatment with a borate; b) reacting the product of step a with a R2-Hal where R2-Hal is defined herein.
    Type: Grant
    Filed: February 10, 2006
    Date of Patent: January 5, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Ahmad Khodabocus, Zhi-Hui Lu, Chris Hugh Senanayake, Hanxun Wei, Yongda Zhang
  • Publication number: 20090264655
    Abstract: Disclosed are processes for making 2, 3 disubstituted indole compounds such as compounds of general formula I comprised of the steps of a) reacting a bromoindole compound (i) with a dialkoxyl C1-5 borane in the presence of a ligand, a palladium catalyst and a base to make a compound of general formula (ii); or alternatively reacting compound (i) with a trialkyl magnesiate reagent, followed by treatment with a borate; b) reacting the product of step a with a R2-Hal where R2-Hal is defined herein.
    Type: Application
    Filed: June 19, 2009
    Publication date: October 22, 2009
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Ahmad KHODABOCUS, Zhi-Hui Lu, Chris Hugh Senanayake, Hanxun Wei, Yongda Zhang
  • Publication number: 20080214870
    Abstract: This invention provides intermediates useful in a method of preparing amine stereoisomers. It also provides a method of preparing sulfoxide and sulfinylamine stereoisomers using certain of the intermediates.
    Type: Application
    Filed: February 18, 2008
    Publication date: September 4, 2008
    Inventors: Zhengxu Han, Dhileepkumar Krishnamurthy, Chris Hugh Senanayake, Zhi-Hui Lu
  • Patent number: 7408076
    Abstract: Disclosed are 2-bromoaniline or 2-chloroaniline compounds of formula (I): wherein R, R1 and X are as defined. The compounds are useful as intermediates for preparing indole compounds.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: August 5, 2008
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Guisheng Li, Jianxiu Liu, Zhi-Hui Lu, Frank Roschangar, Chris Hugh Senanayake, Ming Shen
  • Patent number: 7332614
    Abstract: The present invention provides a process for making a compound of general formula I: wherein: R=H or C1-8alkyl X=C3-C8cycloalkyl, C3-C8aryl or C3-C8alkyl; Y=heteroaryl or aryl; Z=H, HO2Cā€”, C1-8alkyl O2Cā€”, C1-6alkyl HNC(O)ā€”, and as described herein.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: February 19, 2008
    Assignee: Boehringer Ingelheim International, GmbH
    Inventors: Ahmad Khodabocus, Guisheng Li, Zhi-Hui Lu, Frank Roschangar, Chris Hugh Senanayake, Ming Shen
  • Patent number: 7332610
    Abstract: This invention provides intermediates useful in a method of preparing amine stereoisomers. It also provides a method of preparing sulfoxide and sulfinylamine stereoisomers using certain of the intermediates.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: February 19, 2008
    Assignee: Apsinterm LLC
    Inventors: Zhengxu Han, Dhileepkumar Krishnamurthy, Chris Hugh Senanayake, Zhi-Hui Lu
  • Publication number: 20070021330
    Abstract: The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt, ester, or prodrug, thereof, which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Application
    Filed: May 19, 2004
    Publication date: January 25, 2007
    Applicant: Enanta Pharmaceuticals, Inc.
    Inventors: Frank Wu, Suanne Nakajima, Yat Or, Zhi-Hui Lu, Ying Sun, Zhenwei Miao, Zhe Wang
  • Publication number: 20060287376
    Abstract: The present invention provides indole compounds of general formula III comprising the compounds of formula (III); wherein R, and R1-3 a defined herein.
    Type: Application
    Filed: August 29, 2006
    Publication date: December 21, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Guisheng LI, Jianxiu Liu, Zhi-Hui Lu, Frank Roschangar, Chris Senanayake, Ming Shen