Patents by Inventor Zhi Mei Wang

Zhi Mei Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for detecting genetic mutations resulting in protease inhibitor insufficiencies
    Patent number: 5827662
    Abstract: A method of producing a recombinant serine protease inhibitor capable of effectively modulating serine protease activity is provided. Compositions capable of modulating serine protease activity and use of such compositions to regulate inflammatory processes in cells are also provided.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: October 27, 1998
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Harvey Rubin, Barry Cooperman, Norman Schechter, Michael Plotnick, Zhi Mei Wang
  • .alpha.-1-antichymotrypsin analogues having chymase inhibiting activity
    Patent number: 5723316
    Abstract: The invention provides analogues of .alpha.-1-antichymotrypsin having amino acid substitutions at position 358. .alpha.-1-antichymotrypsin analogues having amino acid substitutions at positions 356-361 and analogues having amino acid substitutions at positions 356-361 wherein the amino acid at position 358 is substituted are also within the scope of the invention. These analogues exhibit chymase inhibitory activity. Also provided are novel .alpha.-1-antichymotrypsins having an N-terminal extension of methionine-alanine-serine or alanine-serine. Expression vectors for the production of .alpha.-1-antichymotrypsins are also provided. The present invention also provides host cells and cell cultures capable of expressing analogues of .alpha.-1-antichymotrypsin, as well as protein preparations from the host cells. Methods of producing and using the analogues of .alpha.-1-antichymotrypsin to inhibit chymase activity are also provided.
    Type: Grant
    Filed: March 31, 1994
    Date of Patent: March 3, 1998
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Barry S. Cooperman, Harvey Rubin, Norman Schechter, Zhi Mei Wang
  • .alpha.-1-antichymotrypsin analogues having elastase inhibitory activity
    Patent number: 5674708
    Abstract: The present invention provides an analogue of human .alpha.-1-antichymotrypsin wherein the amino acid at position 358 is selected from the group consisting of isoleucine, valine, alanine, aspattic acid, threonine, and glutamic acid.
    Type: Grant
    Filed: March 31, 1994
    Date of Patent: October 7, 1997
    Assignee: Trustees of the University of Pennsylvania
    Inventors: Barry S. Cooperman, Harvey Rubin, Norman Schechter, Zhi Mei Wang