Abstract: Systems and methods for determining a target multi-source model of a radiation source corresponding to an energy spectrum is provided. The systems may obtain an initial multi-source model of the radiation source, which includes an initial phase space file that includes information of a plurality of simulated particles of a plurality of energy levels. The systems may estimate, based on the initial phase space file, a plurality of component PDD curves corresponding to the plurality of energy levels. The systems may obtain a measured PDD curve corresponding to radiation of the energy spectrum. For each energy level, the systems may determine, based on the plurality of component PDD curves and the measured PDD curve, a weight for the each energy level. The systems may further determine the target multi-source model of the radiation source based at least in part on the initial multi-source model and the weights.

Abstract: Systems and methods for determining a target multi-source model of a radiation source corresponding to an energy spectrum is provided. The systems may obtain an initial multi-source model of the radiation source, which includes an initial phase space file that includes information of a plurality of simulated particles of a plurality of energy levels. The systems may estimate, based on the initial phase space file, a plurality of component PDD curves corresponding to the plurality of energy levels. The systems may obtain a measured PDD curve corresponding to radiation of the energy spectrum. For each energy level, the systems may determine, based on the plurality of component PDD curves and the measured PDD curve, a weight for the each energy level. The systems may further determine the target multi-source model of the radiation source based at least in part on the initial multi-source model and the weights.

Abstract: The present invention includes a foam-forming composition for use in enhanced heavy oil recovery, and a method of using said foam-forming composition for recovering heavy oil and/or bitumen. The foam-forming composition of the present invention comprises a mixture of (di)alkyl diphenyloxide (di)sulfonate compounds and the process of heavy oil recovery is performed at elevated temperatures using steam.

Abstract: The present invention includes a foam-forming composition for use in enhanced heavy oil recovery, and a method of using said foam-forming composition for recovering heavy oil and/or bitumen. The foam-forming composition of the present invention comprises a mixture of (di)alkyl diphenyloxide (di)sulfonate compounds and the process of heavy oil recovery is performed at elevated temperatures using steam.

Abstract: A system and method can support buffer allocation in a shared memory queue. The shared memory queue can be associated with a shared memory, to which one or more communication peers are attached. One or more processes can travel through a plurality of memory blocks in the shared memory, and can allocate one or more message buffers in the shared memory mutual exclusively. The allocated message buffers can be used to contain one or more messages for the one or more communication peers. Furthermore, a said process can allocate the message buffers based on an atomic operation on the memory block at the instruction level.

Abstract: A system and method can support intra-node communication based on a shared memory queue. A transactional middleware machine can provide a complex structure with a plurality of blocks in the shared memory, wherein the shared memory is associated with one or more communication peers, and wherein the communication peers include a sender and a receiver of a message that includes the complex structure. Furthermore, the sender can link a head block of the complex structure to a shared memory queue associated with the receiver, wherein the head block is selected from the plurality of blocks in the complex structure. Then, the receiver can access the complex structure based on the head block of the complex structure.

Abstract: The present invention relates to methods of treating multidrug resistance in cancerous cells with phosphodiesterase (PDE) inhibitors, e.g., PDE5 inhibitors. More specifically, the invention relates to methods of treating multidrug resistance that arises, e.g., during administration of chemotherapeutic/antineoplastic (anticancer) agents for treatment of cancer, with a PDE5 inhibitor (e.g., sildenafil, vardenafil, and tadalafil). The invention also relates to methods of treating cancer, e.g., multidrug resistant cancer, using a PDE5 inhibitor in combination with an antineoplastic therapeutic agent. Further, the invention relates to pharmaceutical compositions for treating multidrug resistant cancers comprising a PDE5 inhibitor, or a combination of a PDE5 inhibitor and an antineoplastic agent.

Abstract: The present invention relates to methods of treating multidrug resistance in cancerous cells with phosphodiesterase (PDE) inhibitors, e.g., PDE5 inhibitors. More specifically, the invention relates to methods of treating multidrug resistance that arises, e.g., during administration of chemotherapeutic/antineoplastic (anticancer) agents for treatment of cancer, with a PDE5 inhibitor (e.g., sildenafil, vardenafil, and tadalafil). The invention also relates to methods of treating cancer, e.g., multidrug resistant cancer, using a PDE5 inhibitor in combination with an antineoplastic therapeutic agent. Further, the invention relates to pharmaceutical compositions for treating multidrug resistant cancers comprising a PDE5 inhibitor, or a combination of a PDE5 inhibitor and an antineoplastic agent.

Abstract: A system and method can support intra-node communication based on a shared memory queue. A transactional middleware machine can provide a complex structure with a plurality of blocks in the shared memory, wherein the shared memory is associated with one or more communication peers, and wherein the communication peers include a sender and a receiver of a message that includes the complex structure. Furthermore, the sender can link a head block of the complex structure to a shared memory queue associated with the receiver, wherein the head block is selected from the plurality of blocks in the complex structure. Then, the receiver can access the complex structure based on the head block of the complex structure.

Abstract: A system and method can support buffer allocation in a shared memory queue. The shared memory queue can be associated with a shared memory, to which one or more communication peers are attached. One or more processes can travel through a plurality of memory blocks in the shared memory, and can allocate one or more message buffers in the shared memory mutual exclusively. The allocated message buffers can be used to contain one or more messages for the one or more communication peers. Furthermore, a said process can allocate the message buffers based on an atomic operation on the memory block at the instruction level.

Abstract: The present invention relates to methods of treating multidrug resistance in cancerous cells with phosphodiesterase (PDE) inhibitors, e.g., PDE5 inhibitors. More specifically, the invention relates to methods of treating multidrug resistance that arises, e.g., during administration of chemotherapeutic/antineoplastic (anticancer) agents for treatment of cancer, with a PDE5 inhibitor (e.g., sildenafil, vardenafil, and tadalafil). The invention also relates to methods of treating cancer, e.g., multidrug resistant cancer, using a PDE5 inhibitor in combination with an antineoplastic therapeutic agent. Further, the invention relates to pharmaceutical compositions for treating multidrug resistant cancers comprising a PDE5 inhibitor, or a combination of a PDE5 inhibitor and an antineoplastic agent.

Abstract: An automatic bulk filling process for filling a large number of liquid containers (20) simultaneously which consists of placing the open-topped liquid containers upside down in a rack (22). The rack is then inserted into a vacuum chamber (28) and positioned directly above a tray (38) that contains a liquid medicinal product (40). The next step is to evacuate the chamber to a predetermined level below atmospheric pressure and then lowering the rack until the containers are partially immersed in the liquid product. Following that step, nitrogen is introduced into the vacuum chamber at a predetermined gradual rate, thereby quickly forcing the medicinal liquid product into the containers. The rack is then raised from the tray containing the liquid medicinal product and removed from the chamber as another rack full of containers is simultaneously inserted into the chamber from the other end.

Abstract: Novel methods for positron emission tomography or single photon emission spectroscopy using tracer compounds having the structure: ##STR1## where X in .beta. configuration isphenyl, naphthyl; 2,3 or 4-iodophenyl; 2,3 or 4-(trimethylsilyl)phenyl; 3,4,5 or 6-iodonaphthyl; 3,4,5 or 6-(trimethylsilyl)naphthyl; 2,3 or 4-(trialkylstannyl)phenyl; or 3,4,5 or 6-(trialkylstannyl)napthylY in .beta. configuration is2-fluoroethoxy, 3-fluoropropoxy, 4-fluorobutoxy, 2-fluorocyclopropoxy, 2 or 3-fluorocyclobutoxy, R,S 1'-fluoroisopropoxy, R 1'-fluoroisopropoxy, S 1'-fluoroisopropoxy, 1',3'-difluoroisopropoxy, R,S 1'-fluoroisobutoxy, R 1'-fluoroisobutoxy, S 1'-fluoroisobutoxy, R,S 4'-fluoroisobutoxy, R 4'-fluoroisobutoxy, S 4'-fluoroisobutoxy, or 1',1'-di(fluoromethyl)isobutoxy,The compounds bind dopamine transporter protein and can be labeled with .sup.18 F or .sup.123 I for imaging.

Abstract: Novel compounds having the structure: ##STR1## where X in .beta. configuration is phenyl, naphthyl; 2,3 or 4-iodophenyl; 2,3 or 4-(trimethylsilyl)phenyl; 3,4,5 or 6-iodonaphthyl; 3,4,5 or 6-(trimethylsilyl)naphthyl; 2,3 or 4-(trialkylstannyl)phenyl; or 3,4,5 or 6-(trialkylstannyl)naphthylY in .beta. configuration is Y.sub.1 or Y.sub.2,whereY.sub.1 is 2-fluoroethoxy, 3-fluoropropoxy, 4-fluorobutoxy, 2-fluorocyclopropoxy, 2 or 3-fluorocyclobutoxy, R,S 1'-fluoroisopropoxy, R 1'-fluoroisopropoxy, S 1'-fluoroisopropoxy, 1',3'-difluoroisopropoxy, R,S 1'-fluoroisobutoxy, R 1'-fluoroisobutoxy, S 1'-fluoroisobutoxy, R,S 4'-fluoroisobutoxy, R 4'-fluoroisobutoxy, S 4'-fluoroisobutoxy, or 1',1'-di(fluoromethyl)isobutoxy, andY.sub.