Abstract: Disclosed are an antibody drug conjugate, a preparation method therefor and an application thereof, which are in particular, a conjugate of an anti-PD-L1 antibody and a TLR7 and/or TLR8 agonist, a pharmaceutical composition thereof, a preparation method therefor and an application thereof. In the present invention, a modified anti-PD-L1 antibody having mutated cysteine is obtained by means of gene editing, basically retains the structure of the original antibody, and may be used for the construction of antibody drug conjugates. By means of anti-tumor experiments, it has been discovered that the obtained antibody drug conjugate has good activity, such as strong anti-tumor activity, which may significantly improve the survival rate of tumor-bearing animals, and significantly reduce toxicity.

Abstract: Disclosed in the present invention are a pyridine-2-amine derivative and a pharmaceutical composition and use thereof. The pyridine-2-amine derivative can be used as a TLR8 selective agonist, has the characteristics of high selectivity, strong activity and high safety, can be used for preventing and/or treating diseases related to TLR activity, for example, diseases caused by or related to pathogen infection, immunological diseases, inflammation, and tumors, can also be used for preparing a vaccine adjuvant to enhance immune response, and has better application prospects and research and development value.

Abstract: A method, a device and a storage medium for processing a communication service in a circuit switch domain are provided. The method may include: judging, when a communication service being currently processed by a communication terminal is a voice call service or a short message service in a circuit switch domain, whether a switching condition for switching the communication service onto a real-time communication tool in a packet switch domain of the communication terminal is met; if it is met, switching the communication service onto the real-time communication tool in the packet switch domain of the communication terminal.

Abstract: A method, a device and a storage medium for processing a communication service in a circuit switch domain are provided. The method may include: judging, when a communication service being currently processed by a communication terminal is a voice call service or a short message service in a circuit switch domain, whether a switching condition for switching the communication service onto a real-time communication tool in a packet switch domain of the communication terminal is met; if it is met, switching the communication service onto the real-time communication tool in the packet switch domain of the communication terminal.

Abstract: This invention provides method and device for blind transfer service. The method comprises the following steps: first, user A establishes a call with user B, then, user B originates a call transfer request to request to transfer the call with user A to user C; application server of user B heads off the request and returns an accept response to user B; the application server of user B firstly originates a call invitation to user C and acquires media parameter information of user C; the application server of user B originates a call re-invitation to user A, provides the media parameter information of user C, instructs user A to carry out media switch, and acquires media parameter information of user A; the application server of user B provides the media parameter information of user A to user C, and instructs user C to establish a media stream connection with user A.

Abstract: This invention provides consultative transfer service method and apparatus.

Abstract: A method for enhanced Capon beamforming includes the steps of providing a sensor array including a plurality of sensor elements where an array steering vector corresponding to a signal of interest (SOI) is unknown. A covariance matrix fitting relation is bounded for the unknown array steering vector by constraining the array steering vector using a constant norm and a spherical uncertainty set. The matrix fitting relation is then solved to provide an estimate of said array steering vector.

Abstract: A method for enhanced Capon beamforming includes the steps of providing a sensor array including a plurality of sensor elements where an array steering vector corresponding to a signal of interest (SOI) is unknown. A covariance matrix fitting relation is bounded for the unknown array steering vector by constraining the array steering vector using a constant norm and a spherical uncertainty set. The matrix fitting relation is then solved to provide an estimate of said array steering vector.

Abstract: A method for enhanced Capon beamforming, referred to herein as an advanced robust Capon beamformer (advanced RCB), includes the steps of providing a sensor array including a plurality of sensor elements, wherein an array steering vector corresponding to a signal of interest (SOI) is unknown. The array steering vector is represented by an ellipsoidal uncertainty set. A covariance fitting relation for the array steering vector is bounded with the uncertainty ellipsoid. The matrix fitting relation is solved to provide an estimate of the array steering vector.

Abstract: A method for enhanced Capon beamforming, referred to herein as an advanced robust Capon beamformer (advanced RCB), includes the steps of providing a sensor array including a plurality of sensor elements, wherein an array steering vector corresponding to a signal of interest (SOI) is unknown. The array steering vector is represented by an ellipsoidal uncertainty set. A covariance fitting relation for the array steering vector is bounded with the uncertainty ellipsoid. The matrix fitting relation is solved to provide an estimate of the array steering vector.