Abstract: The present application belongs to the technical field of proteolysis-targeting chimeras (PROTACs), and discloses a PROTAC molecule and a preparation method and use thereof. A ligand for a target protein in the PROTAC molecule of the present application is a pyridine carboxylic acid-1-oxide derivative. In cell and zebrafish experiments, the PROTAC molecule exhibits no toxic and side effects at a drug concentration allowing a desired effect. At a cellular level, an inhibition level of the PROTAC molecule for human tyrosinase (TYR) reaches less than or equal to 1 ?mol/L. The PROTAC molecule in the present application can significantly reduce the generation of melanin by degrading TYR, and has excellent solubility, safety, and efficacy and a low effective concentration.

Abstract: A building control device includes a printed circuit board (PCB) assembly with a controller. A lighting assembly is operatively coupled to the PCB and is controlled by the controller. The lighting assembly includes a light guide that extends around a periphery of an interposing region. The light guide having a front face and one or more light sources optically coupled to the light guide such that light provided by the one or more light sources enters the light guide and is distributed to the front face of the light guide to provide a diffuse light output. A cover forms at least part of a front face of the building control device and includes a transparent region in registration with at least part of the front face of the light guide.

Abstract: A display panel and a display device. The display panel includes: a driving substrate, a pixel defining layer, and repeating units. Each repeating unit includes: an electrically conductive isolation structure, including a first electrically conductive isolation structure and a second electrically conductive isolation structure; wherein the first electrically conductive isolation structure forms a first pixel holding region and a second pixel holding region; a side of the second electrically conductive isolation structure toward the first electrically conductive isolation structure is formed with a third pixel holding region.

Abstract: The present disclosure provides an efficient phosphorus-containing toughening reactive flame retardant and a preparation method thereof, and a flame-retardant thermosetting resin, and relates to the technical field of material flame retardancy. In the present disclosure, the reactive flame retardant includes phosphorus, and can improve a flame-retardant performance of the thermosetting resin; meanwhile, the flame retardant further includes reactive N—H activated bonds that can participate in a curing reaction of the thermosetting resin, increasing a degree of cross-linking of the thermosetting resin to further improve tensile properties; in addition, the reactive flame retardant further includes a sacrificial bond structure to improve an impact performance of the thermosetting resin.

Abstract: Provided are a pressure-pump cartridge and a pressure pump, where the pressure-pump cartridge includes a cylinder, where the cylinder has a first chamber, a piston chamber and a second chamber hat are in communication in sequence, and the piston chamber is used for being in sealing fit with a piston. An end of the first chamber remote from the piston chamber is provided with a first opening allowing entry of the piston, and during installation, the piston enters the first chamber by the first opening and enters the piston chamber after passing through the first chamber, and meanwhile, the first chamber is configured to be in a clearance fit with the piston, such that the size of the first chamber is larger than that of the piston.

Abstract: A display panel includes a driving substrate, a conductive enclosure structure arranged on the driving substrate and including an insulation layer and a plurality of first metal layers, and a touch control electrode layer arranged on a side of the conductive enclosure structure away from the driving substrate. The insulation layer and the plurality of first metal layers are stacked in sequence along a direction away from the driving substrate. The plurality of first metal layers are arranged on a same plane at intervals. The touch control electrode layer includes a plurality of first touch control electrodes. The plurality of first touch control electrodes extend to the plurality of first metal layers, and adjacent electrodes of the plurality of first touch control electrodes are bridged through the corresponding one of the plurality of first metal layers. A display device is also provided.

Abstract: The present invention belongs to the technical field of fluorine chemical industry, specifically relates to a preparation method of trans-1,1,1,4,4,4-hexafluoro-2-butene, comprising the following steps: preheating trans-2-ethoxy-1,1,1,4,4,4-hexafluoro-2-butene, mixing with hydrogen, reacting to obtain trans-1,1,1,4,4,4-hexafluoro-2-butene under the action of a catalyst. The selectivity of trans 1,1,1,4,4,4-hexafluoro-2-butene prepared by the preparation method of the present invention can reach 99%, the preparation method adopts moderate reaction temperature and produces less three wastes. The trans 1,1,1,4,4,4-hexafluoro-2-butene prepared by the preparation method has great application value in electric power, electrical appliances and electronics industries.

Abstract: A wireless communications method and device are provided. The method and device lower bit overheads and reduce the complexity of terminal processing in the sending of a synchronization signal (SS) block. The method includes determining that a first indication field in a physical broadcasting channel (PBCH) included in a first SS block is used to indicate a physical resource block (PRB) grid offset between channels or signals of an SS block and a non-SS block or indicate resource information of a second SS block. The method further includes sending the first SS block, wherein when it is determined that the first indication field is used to indicate the resource information of the second SS block, the first indication field in the first SS block indicates the resource information of the second SS block.

Abstract: A medical device for causing the hemostasis of a blood vessel for use through an endoscope comprises: a handle; a sheath device, which is attached to the handle; a clamp device including a clamp housing provided on the distal end of the sheath device and at least two, in particular exactly two clamp arms; a control wire extending through the sheath device and reversibly movable in the distal and proximal direction; an actuator coupled to the proximal end of the control wire and actuable to reversibly move the control wire in the distal and proximal direction; wherein the clamp arms are each coupled to the distal end of the control wire.

Abstract: The present disclosure discloses an organic electroluminescent compound, a composition, a light emitting device and an application. The organic electroluminescent compound is a compound M having a structure shown in Formula (2), and Formula (2) is: in Formula (2), X1-X14 are selected from N or CR8, and R8 is selected from hydrogen or deuterium; L is selected from a connecting bond, substituted or unsubstituted C6-C30 arylenyl, and substituted or unsubstituted C3-C30 heteroarylenyl; Ar8-Ar9 are each independently selected from substituted or unsubstituted C6-C30 aryl and substituted or unsubstituted C3-C30 heteroaryl; and substituents are selected from one of or a combination of two of deuterium, halogen, cyano, C1-C6 alkyl, C3-C30 cycloalkyl, C6-C30 aryl and C3-C30 heteroaryl.

Abstract: A medical device for causing the hemostasis of a blood vessel for use through an endoscope comprises: a handle; a sheath device; a clamp device including a clamp housing defining a longitudinal direction with a clamp base in particular in the form of a sleeve provided on the distal end of the sheath device and at least two, in particular exactly two clamp arms, said clamp housing defining an interior space; a control wire extending through the sheath device and reversibly movable in the distal and proximal direction; and an actuator coupled to the proximal end of the control wire and actuable to reversibly move the control wire in the distal and proximal direction; wherein the clamp arms are each coupled to the distal end of the control wire and wherein the clamp device is actuable to open and close the clamp arms.

Abstract: A slide slot type multi-arm clamp includes a handle, a catheter, a clamping portion, a spring tube and a control line. In practical applications, a surgical operator applies an axial thrust and a pulling force to the handle to drive the control line to move, so as to open/close and lock the clamping portion. Moreover, side clamp arms and a clamp base in the clamping portion can be easily separated from the catheter or the spring tube to stay in a human body so as to achieve the functions of hemostasis and tissue suture. The side slot type multi-arm clamp can achieve the effect of minimizing the length of the instrument retained in the human body by the cooperation between the side clamp arms and the clamp base.

Abstract: Provided is a multifunctional high-frequency electric knife, comprising processing portion, sheath portion, and operating portion. The processing portion is provided with an electrode and a clip component; the electrode is provided with a hollow tubular portion; the electrode can be pushed out or retracted relative to far end of the sheath portion; the clip component can be pushed out or retracted relative to far end of the sheath portion; the sheath portion is disposed at near end of the processing portion and comprises a hollow pull rod and a spring tube; and the operating part is located at near end of the sheath portion and comprises a high-frequency joint connected to the electrode by wire, a component driving, by operating line, the electrode to move, a member driving the hollow pull rod to move, and a liquid inlet allowing liquid to flow to the hollow tubular portion of the electrode.

Abstract: Dual-channel injection bipolar high frequency electrosurgical knife comprises an electrode part, a main part and an operation part. The electrode part comprises an active electrode, an insulating part and an inert electrode. The active electrode has a hollow tubular portion, which can cut the target lesion tissue when power on. The main part comprises a protective tube, an insulation sheath and an insulation coated screw, connector, seal. The insulation coated screw includes a conductive screw and an insulating coating on the surface. The operation part comprises a positioning structure, a slider, a core rod, a connection sheath, an infusion tube and a connection cable. 6% Luer tapers are attached to both the positioning structure and the infusion tube. Liquid can flow out from the dual-channel, a solution can be injected in submucosal layer to elevate the mucous membrane tissue or clean hemorrhage site.

Abstract: An electrode for electrochemical applications is coated with a layer of a-C, wherein the layer of a-C comprises at least 10 each of first and second sub-layers, being—(i) first sub-layers having high conductivity with a sp2 content of 60-95%, alternating with—(ii) second sub-layers having high corrosion resistance with a sp2 content of 50-90%, wherein the sp2 content of the first sub-layers is at least 3% greater than the sp2 content of the second sub-layers. A method of making such electrodes comprises: —a) depositing a first sub-layer comprising a-C, —b) depositing a second sub-layer comprising a-C wherein the sp2 content of the first sub-layer is at least 3% greater than the sp2 content of the second sub-layer, and—c) repeating the steps above to deposit at least 10 first sub-layers alternating with 10 second sub-layers, so as to produce the electrodes.

Abstract: An electrode for electrochemical applications is coated with a layer of a-C, wherein the layer of a-C comprises at least 10 each of first and second sub-layers, being (i) first sub-layers having high conductivity with a sp2 content of 60-95%, alternating with (ii) second sub-layers having high corrosion resistance with a sp2 content of 50-90%, wherein the sp2 content of the first sub-layers is at least 3% greater than the sp2 content of the second sub-layers. A method of making such electrodes comprises:?a) depositing a first sub-layer comprising a-C, ?b) depositing a second sub-layer comprising a-C wherein the sp2 content of the first sub-layer is at least 3% greater than the sp2 content of the second sub-layer, and ?c) repeating the steps above to deposit at least 10 first sub-layers alternating with 10 second sub-layers, so as to produce the electrodes.

Abstract: An anastomosis clamp (1) and a delivery system thereof, where the anastomosis clamp (1) includes inner lancets (102, 602), round corners (103, 603), and outer rings (101, 601) that are sequentially connected; the delivery system may be used in cooperation with the anastomosis clamp (1); and the delivery system includes a distal end (2), a middle flexible sheath (3), and a handle (4).

Abstract: A bipolar plate for a PEM hydrogen fuel cell is coated with a carbon-containing coating, the carbon-containing coating comprising in order: a) a titanium seed layer; b) a titanium nitride interfacial layer; and c) a a-C top layer, and wherein the bipolar plate is formed from stainless steel. Methods for making such coated plates are described. The a-C has a density of greater than 2.0 g/cm3, a molar hydrogen content of 5% or less, an sp2 carbon content of 40% to 80% and an sp3 carbon content of 20% to 60%. The coated plates possess good electrical conductivity and are resistant to corrosion.

Abstract: A cold snare includes a spring tube, a drive wire, and a loop. The cable passes through the spring tube, and can perform reciprocating motion in a direction of a longitudinal axis of the spring tube. The loop is fixedly connected to a distal end of the drive wire. Therefore, when the drive wire performs reciprocating motion in the direction of the longitudinal axis of the spring tube, the loop synchronously performs reciprocating motion in the direction of the longitudinal axis of the spring tube along with the drive wire to achieve the purpose of controlling the loop to enter and exit the spring tube by the drive wire. By using a spring tube as an outer tube, the strength of the spring tube is higher than that of a plastic outer tube of an existing cold snare, which is helpful for the loop to cut when grabbing large polyps.

Abstract: A clip device with separable connection and having variable connection force, comprising a clipping portion and a delivery portion. The clipping portion comprises at least two side clipping arms and a clipping base. The side clipping arms are provided in the clipping base, and the proximal ends of the side clipping arms are connected to a control wire. A connection member for fixation and a connection member for separation are provided on the clipping portion. A distal end of the control wire is provided with a releaser, and the tail ends of the side clipping arms are connected to the releaser. During a clipping process, the side clipping arms may apply a larger gripping force on clipped tissues. During a releasing process, the control wire is ensured to apply a smaller dragging force, so as to separate the tail ends of the side clipping arms and the releaser.