Patents by Inventor Zhi-yong Yang

Zhi-yong Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination for site-specifically transforming cells in vivo comprising a double-balloon catheter and nucleic acid comprising a gene encoding P21
    Patent number: 7087582
    Abstract: The present invention provides a combination including a double-balloon catheter and a nucleic acid encoding the cyclin dependent kinase inhibitor p21. The nucleic acid may also encode HLA-B7, an immunotherapeutic agent, a cytokine or a prodrug converting enzyme.
    Type: Grant
    Filed: September 18, 2000
    Date of Patent: August 8, 2006
    Assignee: Regents of the University of Michigan
    Inventors: Gary J. Nabel, Zhi-yong Yang, Elizabeth G. Nabel
  • DEVELOPMENT OF A PREVENTIVE VACCINE FOR FILOVIRUS INFECTION IN PRIMATES
    Publication number: 20060148087
    Abstract: The present invention relates generally to viral vaccines and, more particularly, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.
    Type: Application
    Filed: November 24, 2004
    Publication date: July 6, 2006
    Inventors: Gary Nabel, Zhi-yong Yang
  • Targeting gene transfer vectors to certain cell types by pseudotyping with viral glycoprotein
    Publication number: 20050130129
    Abstract: The present invention provides compositions and methods for targeting gene transfer vectors to certain cell types by pseudotyping with a transmembrane form of viral glycoprotein, such as that from Ebola virus. The methods comprise the step of administering to a cell population a gene to be transferred operatively linked to an appropriate transfer vehicle, wherein the transfer vehicle is associated with a transmembrane form of viral glycoprotein.
    Type: Application
    Filed: June 3, 2004
    Publication date: June 16, 2005
    Inventors: Gary Nabel, Rafael Delgado, Zhi-yong Yang
  • Methods for coating stents with DNA and expression of recombinant genes from DNA coated stents in vivo
    Publication number: 20050038499
    Abstract: The present invention describes DNA coated stents and methods of using the same to treat or prevent vascular diseases, such as restenosis.
    Type: Application
    Filed: September 22, 2004
    Publication date: February 17, 2005
    Inventors: Elizabeth Nabel, Gary Nabel, Zhi-yong Yang
  • Development of a preventive vaccine for filovirus infection in primates
    Publication number: 20040259825
    Abstract: The present invention relates generally to viral vaccines and, more particularly, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.
    Type: Application
    Filed: August 23, 2004
    Publication date: December 23, 2004
    Inventors: Gary Nabel, Zhi-yong Yang, Nancy Sullivan, Anthony Sanchez
  • Methods for coating stents with DNA and expression of recombinant genes from DNA coated stents in vivo
    Patent number: 6818016
    Abstract: The present invention describes DNA coated stents and methods of using the same to treat or prevent vascular diseases, such as restenosis.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: November 16, 2004
    Assignee: The Regents of the University of Michigan
    Inventors: Elizabeth G. Nabel, Gary J. Nabel, Zhi-yong Yang
  • Methods for treating restenosis with p21
    Patent number: 6218372
    Abstract: The p21 gene encodes a cyclin dependent kinase inhibitor which affects cell cycle progression, but the role of this gene product in altering tumor growth has not been established. The present inventors have now discovered that the growth of malignant cells in vivo is inhibited by expression of p21. Expression of p21 resulted in an accumulation of cells in G0/G1, alteration in morphology, and cell differentiation.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: April 17, 2001
    Assignee: The Trustees of the University of Michigan
    Inventors: Gary J. Nabel, Zhi-yong Yang, Elizabeth G. Nabel
  • Methods for treating cancers and restenosis with p21
    Patent number: 6057300
    Abstract: The p21 gene encodes a cyclin dependent kinase inhibitor which affects cell cycle progression, but the role of this gene product in altering tumor growth has not been established. The present inventors have now discovered that the growth of malignant cells in vivo is inhibited by expression of p21. Expression of p21 resulted in an accumulation of cells in G.sub.0 /G.sub.1, alteration in morphology, and cell differentiation.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: May 2, 2000
    Assignee: University of Michigan
    Inventors: Gary J. Nabel, Zhi-yong Yang, Elizabeth G. Nabel
  • Methods for treating cancers and restenosis with P21
    Patent number: 5863904
    Abstract: The p21 gene encodes a cyclin dependent kinase inhibitor which affects cell cycle progression, but the role of this gene product in altering tumor growth has not been established. The present inventors have now discovered that the growth of malignant cells in vivo is inhibited by expression of p21. Expression of p21 resulted in an accumulation of cells in G.sub.0 /G.sub.1, alteration in morphology, and cell differentiation.
    Type: Grant
    Filed: September 26, 1995
    Date of Patent: January 26, 1999
    Assignee: The University of Michigan
    Inventors: Gary J. Nabel, Zhi-yong Yang, Elizabeth G. Nabel
  • Recombinant nucleic acids for inhibiting HIV gene expression
    Patent number: 5650306
    Abstract: This invention provides recombinant nucleic acid molecules for enhanced expression of genes that inhibit HIV gene expression. Cells transfected with these recombinant nucleic acids exhibit prolonged cell life. This invention also provides methods of treating individuals infected with HIV by introducing into them the transfected cells of this invention.
    Type: Grant
    Filed: June 7, 1993
    Date of Patent: July 22, 1997
    Assignee: University of Michigan
    Inventors: Gary J. Nabel, Zhi-Yong Yang, Jinsong Liu, Clive Woffendin