Patents by Inventor Zhibiao Fu

Zhibiao Fu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions for treating bacterial infections
    Patent number: 9999617
    Abstract: The present invention is antibiotic compositions having the ability to disrupt a MazEF complex in S. aureus. The compositions also have the ability to inhibit growth of S. aureus and as such are useful as antibiotic compounds.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: June 19, 2018
    Assignee: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Ambrose Cheung, Zhibiao Fu
  • METHODS FOR SCREENING ANTIBIOTIC COMPOUNDS
    Publication number: 20130295017
    Abstract: The present invention is a method for screening drugs or antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.
    Type: Application
    Filed: November 22, 2011
    Publication date: November 7, 2013
    Applicant: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Ambrose Cheung, Zhibiao Fu
  • Compositions for Treating Bacterial Infections
    Publication number: 20120122877
    Abstract: The present invention is antibiotic compositions having the ability to disrupt a MazEF complex in S. aureus. The compositions also have the ability to inhibit growth of S. aureus and as such are useful as antibiotic compounds.
    Type: Application
    Filed: July 1, 2010
    Publication date: May 17, 2012
    Applicant: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Ambrose Cheung, Zhibiao Fu
  • Methods for Screening for Antibiotic Compounds
    Publication number: 20120115157
    Abstract: The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.
    Type: Application
    Filed: July 1, 2010
    Publication date: May 10, 2012
    Applicant: Trustees of Dartmouth College
    Inventors: Ambrose Cheung, Zhibiao Fu
  • Methods for Screening for Antibiotic Compounds
    Publication number: 20110158911
    Abstract: The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.
    Type: Application
    Filed: December 15, 2010
    Publication date: June 30, 2011
    Applicant: Trustees of Dartmouth College
    Inventors: Ambrose Cheung, Zhibiao Fu
  • Production of protease from Bacillus stearothermophilus F1
    Publication number: 20050186661
    Abstract: A biologically pure strain of Bacillus stearothermophilus F1 capable of Producing protease which is tolerant to any organic compound selected from the group leucine, cysteine, arginine, glycine, asparagine (BDH) and aspartic acid. Peptone iv derived from soybean was the best organic compound for the enzyme production. Sodium nitrate, ammonium salts and amino acids as sole nitrogen sources interfered with protease formation. In addition Bacteriocin-release-protein (BRP) system was used for the release of heterologous proteins from Escherichia coli into culture medium. The gene from the alkaline protease was cloned from Bacillus stearothermophilus F1 and the recombinant F1 protease was efficiently excreted into the culture medium using two vectors pTrcHis bearing the protease gene and pJL3 containing the BRPs. The recombinant enzyme was purified through single-step heat treatment at 70° C. for 3 hours at pH level from 8 to 10.
    Type: Application
    Filed: February 18, 2005
    Publication date: August 25, 2005
    Inventors: Raja Noor Zaliha Rahman, Abu Salleh, Mahiran Basri, Che Nyonya Razak, Kamaruzaman Ampon, Khatijah Yusoff, Suhaili Hamid, Zhibiao Fu