Patents by Inventor Zhibiao Wang
Zhibiao Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200385750Abstract: This invention relates to the identification of a regulator protein (termed CYP78A6, or EOD3) which controls the size of plant seeds and organs in Arabidopsis and other plants. Manipulation of CYP78A protein expression may useful, for example, in improving crop yield and increasing plant biomass.Type: ApplicationFiled: August 14, 2020Publication date: December 10, 2020Inventors: Yunhai Li, Wenjuan Fang, Zhibiao Wang, Rongfeng Cui
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Patent number: 10787676Abstract: This invention relates to the identification of a regulator protein (termed CYP78A6, or EOD3) which controls the size of plant seeds and organs in Arabidopsis and other plants. Manipulation of CYP78A protein expression may useful, for example, in improving crop yield and increasing plant biomass.Type: GrantFiled: June 20, 2017Date of Patent: September 29, 2020Assignee: Institute of Genetics and Development Biology Chinese Academy of SciencesInventors: Yunhai Li, Wenjuan Fang, Zhibiao Wang, Rongfeng Cui
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Publication number: 20170298377Abstract: This invention relates to the identification of a regulator protein (termed CYP78A6, or EOD3) which controls the size of plant seeds and organs in Arabidopsis and other plants. Manipulation of CYP78A protein expression may useful, for example, in improving crop yield and increasing plant biomass.Type: ApplicationFiled: June 20, 2017Publication date: October 19, 2017Inventors: Yunhai Li, Wenjuan Fang, Zhibiao Wang, Rongfeng Cui
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Patent number: 9708625Abstract: This invention relates to the identification of a regulator protein (termed CYP78A6, or EOD3) which controls the size of plant seeds and organs in Arabidopsis and other plants. Manipulation of CYP78A protein expression may useful, for example, in improving crop yield and increasing plant biomass.Type: GrantFiled: January 15, 2013Date of Patent: July 18, 2017Assignee: Institute of Genetics and Developmental Biology Chinese Academy of SciencesInventors: Yunhai Li, Wenjuan Fang, Zhibiao Wang, Rongfeng Cui
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Patent number: 9242121Abstract: An ultrasonic transducer is disclosed, which includes one or a plurality of ultrasonic emitting units. Wavefronts of the ultrasonic waves emitted by the one or the plurality of ultrasonic emitting units are sphere surfaces with uniform radius, and the one or the plurality of ultrasonic emitting units can reflect ultrasound. The one ultrasonic emitting unit is configured to form a spherical resonant cavity, or the plurality of ultrasonic emitting units are configured to form a spherical resonant cavity collectively. An internal cavity of the spherical resonant cavity has a spherical shell shape or a cross-sectional spherical shell shape with a spherical center therein. The ultrasonic waves emitted by the one or the plurality of ultrasonic emitting units are focused on an area in which the spherical center of the spherical resonant cavity is located.Type: GrantFiled: April 2, 2011Date of Patent: January 26, 2016Assignee: CHONGQING HAIFU MEDICAL TECHNOLOGY CO., LTD.Inventors: Zhibiao Wang, Hua Wang, Deping Zeng, Chunliang Zhao, Fangwei Ye, Sanyong Li, Guihua Xu, Xiaobo Gong
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Publication number: 20140366221Abstract: This invention relates to the identification of a regulator protein (termed CYP78A6, or EOD3) which controls the size of plant seeds and organs in Arabidopsis and other plants. Manipulation of CYP78A protein expression may useful, for example, in improving crop yield and increasing plant biomass.Type: ApplicationFiled: January 15, 2013Publication date: December 11, 2014Applicant: Institute of Genetics and Developmental BiologyInventors: Yunhai Li, Wenjuan Fang, Zhibiao Wang, Rongfeng Cui
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Publication number: 20130023801Abstract: An ultrasonic transducer is disclosed, which includes one or a plurality of ultrasonic emitting units. Wavefronts of the ultrasonic waves emitted by the one or the plurality of ultrasonic emitting units are sphere surfaces with uniform radius, and the one or the plurality of ultrasonic emitting units can reflect ultrasound. The one ultrasonic emitting unit is configured to form a spherical resonant cavity, or the plurality of ultrasonic emitting units are configured to form a spherical resonant cavity collectively. An internal cavity of the spherical resonant cavity has a spherical shell shape or a cross-sectional spherical shell shape with a spherical center therein. The ultrasonic waves emitted by the one or the plurality of ultrasonic emitting units are focused on an area in which the spherical center of the spherical resonant cavity is located.Type: ApplicationFiled: April 2, 2011Publication date: January 24, 2013Applicant: CHONGQING HAIFU (HIFU) TECHNOLOGY CO. LTD.Inventors: Zhibiao Wang, Hua Wang, Deping Zeng, Chunliang Zhao, Fangwei Ye, Sanyong Li, Guihua Xu, Xiaobo Gong
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Patent number: 8251929Abstract: The present invention is to provide an integrated ultrasound therapy transducer. It includes a piezoelectric transducer to generate therapy ultrasound, a support to support the piezoelectric transducer, a power amplifying module to drive the piezoelectric transducer. Wherein both the power amplifying module and the piezoelectric transducer are installed within the enclosure of the therapy transducer. The advantages of the integrated ultrasound therapy transducer assembly of the present invention include minimizing ultrasound therapy equipment and to decrease its volume and weight; reducing the electromagnetic interference and radiation greatly; and realizing the consistent performances of the ultrasound therapy equipments in mass productions and making the ultrasound therapy equipments have interchangeability.Type: GrantFiled: September 2, 2005Date of Patent: August 28, 2012Assignee: Chongqing Haifu (Hifu) Technology Co., Ltd.Inventors: Chunliang Zhao, Zhibiao Wang, Zhilong Wang, Jin Bai
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Publication number: 20090117052Abstract: The present invention discloses an enhancement agent for high intensity focused ultrasound (HIFU) treatment, which is administered to a patient before HIFU treatment and can reduce the level of EEF at the target location to be treated with HIFU. EEF is presented by the expression: EEF=?Pt/V (unit: J/mm3), and refers to the HIFU energy needed to effectively treat a tumor per unit volume of the tumor, wherein, ?=0.7; P refers to the total acoustic power of HIFU source (unit: W); t refers to the total time of HIFU treatment (unit: s); V refers to the volume of HIFU-induced lesions (unit: mm3). If the amount of EEF at the target location before administration of the enhancement agent is defined as EEF(base) and the amount of EEF at the target location after administration of the enhancement agent is defined as EEF(measurement), the ratio between EEF(base) and EEF(measurement) is more than 1, preferably more than 2, and more preferably over 4.Type: ApplicationFiled: August 30, 2005Publication date: May 7, 2009Inventors: Zhibiao Wang, Faqi Li, Yanbing Xiao, Ziwen Xiao, Liping Liu, Zhilong Wang
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Publication number: 20090054772Abstract: The present invention pertains to an ultrasound therapy system and more specifically, to a high-intensity focused ultrasound (HIFU) therapy apparatus guided by image registration and fusion method. The therapy system of the present invention comprises a central control means; an acoustic energy applicator; a mechanical driving and locating means of said acoustic energy applicator; a real-time B-mode ultrasound image guiding device. Further the therapy system of the present invention comprises an immobilization means for body position. By the help of this immobilization means for body position, real-time B-mode ultrasound images can be registered with diagnosis images, and then on the basis of registration, said B-mode ultrasound images are fused with said diagnosis images for guiding said therapy.Type: ApplicationFiled: August 26, 2005Publication date: February 26, 2009Applicant: CHONGQING HAIFU(HIFU) TECHNOLOGY CO., LTD.Inventors: Tao Lin, Wenzhi Chen, Yingang Wen, Zhibiao Wang, Zhilong Wang
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Publication number: 20080287835Abstract: The present invention is to provide an integrated ultrasound therapy transducer. It includes a piezoelectric transducer to generate therapy ultrasound, a support to support the piezoelectric transducer, a power amplifying module to drive the piezoelectric transducer. Wherein both the power amplifying module and the piezoelectric transducer are installed within the enclosure of the therapy transducer. The advantages of the integrated ultrasound therapy transducer assembly of the present invention include minimizing ultrasound therapy equipment and to decrease its volume and weight; reducing the electromagnetic interference and radiation greatly; and realizing the consistent performances of the ultrasound therapy equipments in mass productions and making the ultrasound therapy equipments have interchangeability.Type: ApplicationFiled: September 2, 2005Publication date: November 20, 2008Applicant: Chongqing Haifu (HIFU) Technology Co., Ltd.Inventors: Chunliang Zhao, Zhibiao Wang, Zhilong Wang, Jin Bai
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Publication number: 20080281252Abstract: The present invention generally relates to a medical apparatus. More particularly, the present invention relates to an apparatus for delivering a medium to body cavity of mammals including a human, especially to an apparatus for expanding rectum. Specifically, the present invention relates to the field of focused ultrasound treatment with a main purpose to provide an auxiliary device for ultrasound therapy applied to uterine myoma so as to avoid damage by ultrasound after focused within body. Therefore, the present invention provides an apparatus for blocking ultrasound, comprising (1) lead-in means for entering into said body cavity; and (2) accommodation means for containing ultrasound blocking medium, which enwraps the lead-in means outside.Type: ApplicationFiled: August 31, 2005Publication date: November 13, 2008Applicant: CHONGQING HAIFU(HIFU) TECHNOLOGY CO., LTD.Inventors: Zhilong Wang, Zhibiao Wang, Jin Bai, Zhengai Xiong
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Publication number: 20080260790Abstract: The present invention discloses a plasmid enhancement agent for high intensity focused ultrasound (HIFU) treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a nanometer-sized biocompatible solid. The present invention also discloses another plasmid enhancement agent for HIFU treatment, wherein, the enhancement agent comprises a discontinuous phase is comprised of a core material encapsulated by a membrane-forming material, and a continuous phase comprised of aqueous medium; the discontinuous phase is uniformly dispersed in the continuous phase and has a particle size ranging from 10-1000 nm; the amount of the membrane-forming material in the enhancement agent is 0.1-100g/L; and the core material comprises nanometer-sized biocompatible solid selected from the group consisting of magnetic biomaterials, hydroxylapatite, and calcium carbonate, and the amount of the core material in the enhancement agent is 0.1-150 g/L.Type: ApplicationFiled: August 30, 2005Publication date: October 23, 2008Applicant: CHONGQING HAIFU(HIFU) TECHNOLOGY CO., LTD.Inventors: Zhibiao Wang, Faqi Li, Liping Liu, Yanbing Xiao, Ziwen Xiao, Zhilong Wang
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Publication number: 20080188745Abstract: The apparatus for high-intensity focused ultrasound therapy of the present invention usually comprises a ultrasound transducer, an image acquisition device, a driving unit for driving said ultrasound transducer and mechanical drive means for mechanically driving said ultrasound transducer and image acquisition device together. Additionally, this apparatus for high-intensity focused ultrasound therapy further comprises a signal processing unit connected to image acquisition device for receiving and saving the original images of the target area prior to treatment and for receiving and saving the images of the target area in a certain time during high-intensity focused ultrasound (HIFU) treatment and for evaluating the therapeutic effects according to the images of the target area before and after treatment, and a control unit respectively connected to signal processing unit, driving unit and mechanical driving means.Type: ApplicationFiled: August 2, 2005Publication date: August 7, 2008Applicant: CHONGQING HAIFU (HIFU) TECHNOLOGY CO., LTD.Inventors: Wenzhi Chen, Zhibiao Wang, Zhilong Wang, Tao Lin, Chunliang Zhao
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Publication number: 20080139973Abstract: The present invention discloses a particle enhancement agent for high intensity focused ultrasound (HIFU) treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a discontinuous phase comprised of a core material encapsulated by a membrane-forming material and a continuous phase comprising of aqueous medium. The discontinuous phase is uniformly dispersed in the continuous phase and the particle size of the discontinuous phase ranges from 0.1-8 ?m; the amount of the membrane-forming material in the enhancement agent is 0.1-100 g/L; the core material is comprised of a liquid that does not undergo a liquid-gas phase transition at 38-100° C., and the amount of core material in the enhancement agent is 5-200 g/L.Type: ApplicationFiled: September 2, 2005Publication date: June 12, 2008Applicant: CHONGQING HAIFU(HIFU) TECHNOLOGY CO., LTD.Inventors: Zhibiao Wang, Faqi Li, Yanbing Xiao, Ziwen Xiao, Liping Liu, Zhilong Wang
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Publication number: 20080138290Abstract: The present invention discloses a fluorocarbon emulsion enhancement agent for HIFU treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a discontinuous phase comprising of a core material encapsulated by a membrane-forming material and a continuous phase comprised of aqueous medium; the discontinuous phase is uniformly dispersed in the continuous phase and the particle size of the discontinuous phase ranges from 0.1-2 ?m; the amount of the membrane-forming material in the enhancement agent is 0.1-100 g/L; the core material is comprised of a liquid that undergoes a liquid-gas phase transition at 38-100° C., and the amount of the core material in the enhancement agent is 5-200 ml/L. The fluorocarbon emulsion enhancement agent for HIFU treatment of the present invention can significantly change the acoustic environment of the target location and can increase acoustic energy deposition at the target location during HIFU treatment.Type: ApplicationFiled: September 2, 2005Publication date: June 12, 2008Applicant: CHONGQING HAIFU (HIFU) TECHNOLOGY CO., LTD.Inventors: Zhibiao Wang, Faqi Li, Ziwen Xiao, Yanbing Xiao, Liping Liu, Zhilong Wang
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Publication number: 20050080359Abstract: The invention provides an ultrasound therapeutic apparatus for treating skin lesions of human being, comprising a controlling device, an ultrasound transducer transmitting the therapeutic ultrasound beam to the subject, a focusing means. Said controlling device is the electrical control system of the ultrasound therapeutic apparatus. Said ultrasound transducer and said focusing means are placed in an ultrasound applicator, which can be held by hand. The ultrasound applicator, which can be held by hand, includes a handle and a housing forming a lumen and the said ultrasound transducer and said focusing means are placed in the said lumen. The ultrasound applicator can be held by clinicians' hand, performing a treatment on skin lesions of human being including the skin lesions of gynecology more conveniently.Type: ApplicationFiled: December 16, 2002Publication date: April 14, 2005Inventors: Chunliang Zhao, Zhibiao Wang, Zhilong Wang, Fangwei Ye
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Patent number: 6685639Abstract: A high intensity focused ultrasound system for scanning and treating tumor, having a combined probe, a power source, a B-mode ultrasound scanner, a multi-dimensional digit-controlled motional apparatus, a vacuum degassor apparatus, a therapeutic bed, and a computer. The combined probe comprises a B-mode ultrasound probe and a therapeutic head which generates therapeutic focused ultrasound; its ultrasound-emitting end is mounted on the multi-dimensional motional apparatus, and the motional apparatus carries out scanning movement outside the body under the control of the computer, causing the high sound intensity focal region (space-point) generated by the therapeutic head to carry out scanning within the body. By the action of high sound intensity, the temperature of the tissues in the focal region instantaneously rises to over 70 degrees centigrade and the tissues are affected by the mechanical action of cavitation, so degeneration and necrosis occur.Type: GrantFiled: September 11, 2000Date of Patent: February 3, 2004Assignee: Chongqing HifuInventors: Zhilong Wang, Zhibiao Wang, Feng Wu, Jin Bai