Patents by Inventor Zhibing Zheng

Zhibing Zheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120149695
    Abstract: Disclosed are dihydropyrimidine compounds and preparation methods, pharmaceutical compositions and uses thereof. Specifically, the compounds described herein in general formula (I), or their isomers, pharmaceutically acceptable salts or hydrates are provided, wherein each variable has the meaning as defined in the description. Also provided are a process for preparing the compounds of the general formula (I), the use of the compounds, an isomer thereof, a pharmaceutically acceptable salt thereof or a hydrate thereof as a medicament, in particular as a medicament for the treatment and/or prevention of Hepatitis B.
    Type: Application
    Filed: May 27, 2010
    Publication date: June 14, 2012
    Applicant: INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A.
    Inventors: Song Li, Xiaoqian Xu, Guoming Zhao, Lili Wang, Hua Guan, Junhai Xiao, Wu Zhong, Zhibing Zheng, Yunde Xie, Xingzhou Li, Xiaokui Wang, Xinbo Zhou, Hongying Liu
  • Patent number: 8188091
    Abstract: The present invention relates to a compound of formula (I) or isomers thereof, or pharmaceutically acceptable salts or hydrates thereof. The present invention further relates to processes for the preparation of the compounds of formula (I) and optical isomers, and to the use of the compounds of formula (I), or isomers thereof, or pharmaceutically acceptable salts or hydrates thereof as medicaments, in particular as medicaments for the treatment and prevention of Hepatitis B.
    Type: Grant
    Filed: January 3, 2008
    Date of Patent: May 29, 2012
    Assignee: Beijing Molecule Science and Technology Co., Ltd.
    Inventors: Song Li, Xuejun Zhu, Guoming Zhao, Lili Wang, Wu Zhong, Zhibing Zheng, Junhai Xiao
  • Publication number: 20120122914
    Abstract: The present invention relates to a sustained-release composition containing 2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole or a pharmaceutically acceptable salt thereof as an active ingredient, preparation thereof and the compound. The composition is suitable for oral administration by one time per day, and achieves the peak plasma concentration at 1.0 to 3 hours after oral administration. The composition is suitable for manufacturing a medicament for treatment of cognitive dysfunction syndrome, Alzheimer's disease, Parkinson's disease, Huntington's disease, or senile dementia.
    Type: Application
    Filed: March 29, 2010
    Publication date: May 17, 2012
    Applicant: INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCE P.L.A.CHINA
    Inventors: Song Li, Wu Zhong, Zhibing Zheng, Junhai Xiao, Bing Li, Yunde Xie, Xinbo Zhou
  • Patent number: 8173643
    Abstract: The present invention relates to N-Substituted thiomorpholine compounds of formula I, the possible isomers, the pharmaceutically acceptable salts, the solvates, the hydrates or the prodrugs thereof as inhibitors of dipeptidyl peptidase IV (DPP-IV); and to a method for preparing the compounds of formula I, pharmaceutical compositions comprising the compounds of formula I and use of the compounds of formula II in medical field, particularly in the preparation of medicaments for treating and preventing diabetes (in particular type II diabetes), hyperglycemia, X syndrome, hyperinsulinemia, obesity, atherosclerosis and all kinds of diseases modulated by immune system.
    Type: Grant
    Filed: June 1, 2007
    Date of Patent: May 8, 2012
    Assignee: Beijing Molecule Science and Technology Co., Ltd.
    Inventors: Song Li, Wu Zhong, Junhai Xiao, Xinghai Ma, Lili Wang, Hongying Liu, Zhibing Zheng
  • Patent number: 8168642
    Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, to a process for preparing the compound of formula (I), and to use of the compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis.
    Type: Grant
    Filed: July 9, 2007
    Date of Patent: May 1, 2012
    Assignee: Beijing Molecule Science and Technology Co., Ltd.
    Inventors: Song Li, Guoming Zhao, Guangqiang Xia, Lili Wang, Zhibing Zheng, Yunde Xie, Wu Zhong, Junhai Xiao, Xingzhou Li, Hao Cui
  • Patent number: 8106196
    Abstract: The present invention relates to compounds of the formula (I) or pharmaceutically acceptable salts or hydrates thereof. The present invention further relates to processes for the preparation of the compounds of formula (I) and optical isomers and to use of the compounds of formula (I), isomers, pharmaceutically acceptable salts or hydrates thereof as medicaments, in particular as medicaments for the treatment and prevention of Hepatitis B.
    Type: Grant
    Filed: January 3, 2008
    Date of Patent: January 31, 2012
    Assignee: Beijing Molecule Science and Technology Co., Ltd
    Inventors: Song Li, Xuejun Zhu, Guoming Zhao, Lili Wang, Wu Zhong, Zhibing Zheng, Junhai Xiao
  • Patent number: 8076339
    Abstract: The present invention relates to substituted pyridazinylamine derivatives of the formula I or pharmaceutically acceptable salts or hydrates thereof, wherein the substituents are defined as in the description, their preparation process, pharmaceutical compositions comprising them, and uses of the said compounds as picorna virus inhibitors for prevention and/or treatment of diseases caused by picorna viruses.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: December 13, 2011
    Assignee: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China of Beijing
    Inventors: Song Li, Chunlai Mi, Zhibing Zheng, Guoming Zhao, Xinbo Zhou, Zehui Gong
  • Patent number: 8030323
    Abstract: A compound of formula (I) or pharmaceutically acceptable salts and/or solvates or hydrates thereof. A process for preparing the compound, a pharmaceutical composition comprising the compound and an application for resisting cannabinoid CB1 receptor are provided.
    Type: Grant
    Filed: January 10, 2007
    Date of Patent: October 4, 2011
    Assignee: Beijing Molecule Science and Technology Co., Ltd.
    Inventors: Song Li, Mengjia Liu, Zhibing Zheng
  • Publication number: 20110178141
    Abstract: The present invention relates to a composition of a thiazolium compound of formula I or a solvate thereof, wherein the definitions of groups in the formula I are as those given in the claims:
    Type: Application
    Filed: October 15, 2009
    Publication date: July 21, 2011
    Inventors: Song Li, Wu Zhong, Lili Wang, Zhibing Zheng, Hao Cui, Junhai Xiao, Gang Cheng, Yunde Xie, Bing Zhang
  • Publication number: 20110065795
    Abstract: The present invention relates to (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-1-carboxylic acid hydrates compounds, preparing methods thereof, pharmaceutical compositions containing said compounds and preparing methods thereof, and the clinical uses of said compounds as neuramidinase inhibitors for anti-influenza.
    Type: Application
    Filed: August 13, 2008
    Publication date: March 17, 2011
    Inventors: Song Li, Wu Zhong, Zhibing Zheng, Xinbo Zhou, Junhai Xiao, Yunde Xie, Lili Wang, Xingzhou Li, Guoming Zhao, Xiaokui Wang, Hongying Liu
  • Publication number: 20110059978
    Abstract: The present invention relates to substituted pyridazinylamine derivatives of the formula I or pharmaceutically acceptable salts or hydrates thereof, wherein the substituents are defined as in the description, their preparation process, pharmaceutical compositions comprising them, and uses of the said compounds as picorna virus inhibitors for prevention and/or treatment of diseases caused by picorna viruses.
    Type: Application
    Filed: November 15, 2010
    Publication date: March 10, 2011
    Inventors: Song LI, Chunlai MI, Zhibing ZHENG, Guoming ZHAO, Xinbo ZHOU, Zehui GONG
  • Publication number: 20110009427
    Abstract: The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof. Various substituents in the formula (I) are as defined in the specification. The present invention also relates to a pharmaceutical composition comprising the compound of formula (I), the preparation method of compound of formula (I), and the use of the compound for the preparation of a medicament for treating and/or preventing human peroxisome proliferators activated receptor ? (hPPAR?)-associated diseases and risk factors.
    Type: Application
    Filed: July 18, 2008
    Publication date: January 13, 2011
    Applicant: INSTITUE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA
    Inventors: Song Li, Yanbo Yang, Junhai Xiao, Wu Zhong, Zhibing Zheng, Xingzhou Li, Yunde Xie, Lili Wang, Hongying Liu
  • Publication number: 20100331345
    Abstract: The present invention relates to compounds represented by formula (I), or isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof: in which each substituent of formula (I) is as defined in the specification. The present invention also relates to preparation methods of compounds represented by formula (I), a pharmaceutical composition comprising compounds represented by formula (I) and usage of compounds represented by formula (I) for treating chronic neurodegenerative diseases such as Alzheimer's disease and other diseases induced by aggregation or deposition of ?-amyloid peptide.
    Type: Application
    Filed: February 5, 2007
    Publication date: December 30, 2010
    Inventors: Song Li, Guochao Liao, Junhai Xiao, Aihua Nie, Lili Wang, Wu Zhong, Zhibing Zheng
  • Publication number: 20100179116
    Abstract: The present invention relates to arene connected polyamine macrocyclic derivatives represented by general formula I, pharmaceutically acceptable salts or hydrates thereof which have anti-HIV activities, in which the definitions of substituents are as defined in the description; to preparation methods of the compounds of formula I; to pharmaceutical compositions containing the compounds of formula I or their pharmaceutically acceptable salts or hydrates; to the use of the compounds of formula I or their pharmaceutically acceptable salts or hydrates for the preparation of a medicament for the treatment and prevention of HIV-associated diseases.
    Type: Application
    Filed: May 30, 2008
    Publication date: July 15, 2010
    Inventors: Song Li, Jing Su, Yao Liu, Junhai Xiao, Lili Wang, Wu Zhong, Zhibing Zheng, Yunde Kie, Xingzhou Li, Guoming Zhao, Xiaokui Wang, Xinbo Zhou, Hongying Liu
  • Publication number: 20100160383
    Abstract: A compound of formula (I) or pharmaceutically acceptable salts and/or solvates or hydrates thereof. A process for preparing the compound, a pharmaceutical composition comprising the compound and an application for resisting cannabinoid CB1 receptor are provided.
    Type: Application
    Filed: January 10, 2007
    Publication date: June 24, 2010
    Applicant: BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD
    Inventors: Song Li, Mengjia Liu, Zhibing Zheng
  • Publication number: 20100113433
    Abstract: The present invention relates to N-Substituted thiomorpholine compounds of formula I, the possible isomers, the pharmaceutically acceptable salts, the solvates, the hydrates or the prodrugs thereof as inhibitors of dipeptidyl peptidase IV (DPP-IV); and to a method for preparing the compounds of formula I, pharmaceutical compositions comprising the compounds of formula I and use of the compounds of formula II in medical field, particularly in the preparation of medicaments for treating and preventing diabetes (in particular type II diabetes), hyperglycemia, X syndrome, hyperinsulinemia, obesity, atherosclerosis and all kinds of diseases modulated by immune system.
    Type: Application
    Filed: June 1, 2007
    Publication date: May 6, 2010
    Inventors: Song Li, Wu Zhong, Junhai Xiao, Xinghai Ma, Lili Wang, Hongying Liu, Zhibing Zheng
  • Publication number: 20100087448
    Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, to a process for preparing the compound of formula (I), and to use of the compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis.
    Type: Application
    Filed: July 9, 2007
    Publication date: April 8, 2010
    Inventors: Song Li, Guoming Zhao, Guangqiang Xia, Lili Wang, Zhibing Zheng, Yunde Xie, Wu Zhong, Junhai Xiao, Xingzhou Li, Hao Cui
  • Publication number: 20100075988
    Abstract: The present invention relates to a compound of formula (I) or isomers thereof, or pharmaceutically acceptable salts or hydrates thereof. The present invention further relates to processes for the preparation of the compounds of formula (I) and optical isomers, and to the use of the compounds of formula (I), or isomers thereof, or pharmaceutically acceptable salts or hydrates thereof as medicaments, in particular as medicaments for the treatment and prevention of Hepatitis B.
    Type: Application
    Filed: January 3, 2008
    Publication date: March 25, 2010
    Applicant: BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD
    Inventors: Song Li, Xuejun Zhu, Guoming Zhao, Lili Wang, Wu Zhong, Zhibing Zheng, Junhai Xiao
  • Publication number: 20100010013
    Abstract: The present invention relates to compounds of the formula (I) or pharmaceutically acceptable salts or hydrates thereof. The present invention further relates to processes for the preparation of the compounds of formula (I) and optical isomers and to use of the compounds of formula (I), isomers, pharmaceutically acceptable salts or hydrates thereof as medicaments, in particular as medicaments for the treatment and prevention of Hepatitis B.
    Type: Application
    Filed: January 3, 2008
    Publication date: January 14, 2010
    Applicant: BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD.
    Inventors: Song Li, Xuejun Zhu, Guoming Zhao, Lili Wang, Wu Zhong, Zhibing Zheng, Junhai Xiao
  • Publication number: 20100004268
    Abstract: The present invention relates to an optically pure compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, a process for preparing the optically pure compound of formula (I), and use of the optically pure compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis.
    Type: Application
    Filed: July 9, 2007
    Publication date: January 7, 2010
    Inventors: Song Li, Guangqiang Xia, Guoming Zhao, Lili Wang, Zhibing Zheng, Yunde Xie, Wu Zhong, Junhai Xiao, Xingzhou Li, Hao Cui