Abstract: Disclosed are a series of compounds with a nitrogen-containing spiro structure and an application thereof in the preparation of an RET kinase inhibitor. Specifically, disclosed is a compound as shown in formula (II) or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed are a non-fluorinated quinolone compound and use thereof, specifically relating to a compound represented by formula (II) and a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to the technical field of drug synthesis. Disclosed are a crystal form of a macrocyclic compound, and a preparation method therefor and the use thereof. The macrocyclic compound is (6R,16R)-9-fluoro-16-methyl-13-oxa-2,17,21,25-tetraazapentane [16.6.2.02,6.07,12.022,26]dihexadecane-1(25),7,9,11,18(26),19,21,23-octane-19-carbonitrile. The X-ray diffraction pattern of the crystal form has characteristic peaks at 2? values of 9.49±0.2, 10.60±0.2, 11.54±0.2, 14.10±0.2, 17.09±0.2, 19.15±0.2, 20.30±0.2, 22.85±0.2, 23.89±0.2 and 27.74±0.2. The crystal form is hygroscopicity-free, has a good stability and pharmacokinetic properties.

Abstract: A class of piperazine derivatives and application thereof, specifically compound represented by formula (III) or pharmaceutically acceptable salt thereof.

Abstract: Provided are crystal forms of compounds represented by formula(II)-formula (VIII) and formula (I)-formula (VIII-1), a preparation method therefor and an application of the compounds and crystal forms in the preparation of a drug for treating a related disease.

Abstract: Disclosed are a class of compounds represented by formula (II), and isomers or pharmaceutically acceptable salts thereof.

Abstract: A new method for extracting lithium from salt lake brine, comprising the following steps: a salt lake old brine raw material, desorption liquid, low-magnesium water, and adsorption tail liquid pass through an old brine feeding pipe (2), a desorption liquid feeding pipe (4), a low-magnesium water top desorption liquid feeding pipe (3), and an adsorption tail liquid top desorption liquid feeding pipe (11), respectively, which are located above and below a rotary disc of a multi-way valve system (1); and after respectively entering corresponding adsorption columns (6) by means of a duct and channel within the multi-way valve system (1), the entire process procedure is completed from an adsorption tail liquid discharge pipe (7), a qualified desorption liquid discharge pipe (10), a lithium-containing old brine discharge pipe (8), and an adsorption tail liquid top desorption liquid discharge pipe (5); and the adsorption columns (6) are connected in series or in parallel by means of channels located in the multi-way

Abstract: Disclosed is a series of pyrazolopyridine compounds, and application thereof in the preparation of RET kinase inhibitors for treatment. Specifically disclosed is the compound represented by formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed are a series of compounds with a nitrogen-containing spiro structure and an application thereof in the preparation of an RET kinase inhibitor. Specifically, disclosed is a compound as shown in formula (II) or a pharmaceutically acceptable salt thereof.