Patents by Inventor Zhicai Yang

Zhicai Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL ANTIBACTERIAL COMPOUNDS, METHODS OF MAKING THEM, AND USES THEREOF
    Publication number: 20140315255
    Abstract: The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.
    Type: Application
    Filed: February 13, 2014
    Publication date: October 23, 2014
    Applicant: Albany Molecular Research, Inc.
    Inventors: Grant J. Carr, David D. Manning, Zhicai Yang, Cheng Guo, Jun-Ho Maeng, John RABENSTEIN
  • Antibacterial compounds, methods of making them, and uses thereof
    Patent number: 8754054
    Abstract: The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: June 17, 2014
    Assignee: Albany Molecular Research, Inc.
    Inventors: Grant J. Carr, David D. Manning, Zhicai Yang, Cheng Guo, Jun-Ho Maeng, Peter C. Michels, Matthew W. Chase
  • NOVEL ANTIBACTERIAL COMPOUNDS, METHODS OF MAKING THEM, AND USES THEREOF
    Publication number: 20130237490
    Abstract: The present invention relates to novel therapeutics with antibacterial activity, processes for their preparation, and pharmaceutical, veterinary and nutritional compositions containing them as active ingredients. The present invention also relates to uses of the novel therapeutics, for example, as medicants or food additives in the treatment of bacterial infections or to aid body mass gain in a subject.
    Type: Application
    Filed: September 17, 2010
    Publication date: September 12, 2013
    Applicant: Albany Molecular Research, Inc.
    Inventors: Grant J. CARR, David D. MANNING, Zhicai YANG, Cheng GUO, Jun-Ho MAENG, John RABENSTEIN, Peter C. MICHELS, Matthew W. CHASE
  • 2-alkylbenzoxazole carboxamides as 5HT3 modulators
    Patent number: 8278301
    Abstract: Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds are useful in treating CINV, IBS-D and other diseases and conditions.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: October 2, 2012
    Assignee: Albany Molecular Research, Inc.
    Inventors: David D. Manning, Zhicai Yang
  • 2-aminobenzoxazole carboxamides as 5HT3 modulators
    Patent number: 7863271
    Abstract: Compounds of formulae I, II and III: are disclosed as 5-HT3 inhibitors. The compounds are useful in treating CINV, IBS-D and other diseases and conditions.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: January 4, 2011
    Assignee: Albany Molecular Research, Inc.
    Inventors: Zhicai Yang, David D. Manning
  • Processes for stereoselective synthesis of trans ISA247
    Patent number: 7799756
    Abstract: The present invention relates to a process for preparation of a trans ISATX247 compound of the formula: where R1?H or D; R2?H or D; and R3?H or D, by application of organozirconium chemistry. The process involves reacting an acetyl cyclosporin aldehyde with an organozirconium reagent to provide acetyl cyclosporin diene (the acetate of trans ISATX247) and deacetylating the acetyl cyclosporin diene to produce the trans-isomer of ISATX247. The present invention also relates to a process for preparing the same trans ISATX 247 compound, using olefin cross metathesis. The process involves: olefin cross metathesis of acetyl cyclosporin A to afford acetyl cyclosporin ?,?-unsaturated aldehyde; Wittig reaction of the acetyl cyclosporin ?,?-unsaturated aldehyde to provide acetyl cyclosporin diene; and deacetylation of the acetyl cyclosporin diene to produce the trans ISATX247 compound.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: September 21, 2010
    Assignee: Albany Molecular Research, Inc.
    Inventors: Bruce F. Molino, Zhicai Yang, Jun-Ho Maeng, David D. Manning
  • Benzoxazole carboxamides for treating CINV and IBS-D
    Patent number: 7781430
    Abstract: Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds that exhibit central activity are useful in treating CINV; those that inhibit peripheral receptors are useful to treat IBS-D.
    Type: Grant
    Filed: November 2, 2007
    Date of Patent: August 24, 2010
    Assignee: Albany Molecular Research, Inc.
    Inventors: David J. Fairfax, Zhicai Yang
  • Cyclosporin alkynes and their utility as pharmaceutical agents
    Patent number: 7632807
    Abstract: The compounds of the present invention are represented by the chemical structure found in Formula I: or a pharmaceutically acceptable salt thereof, with X, R0, and R1 defined herein.
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: December 15, 2009
    Assignee: Albany Molecular Research, Inc.
    Inventors: Bruce F. Molino, Zhicai Yang
  • 2-ALKYLBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS
    Publication number: 20090227576
    Abstract: Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds are useful in treating CINV, IBS-D and other diseases and conditions.
    Type: Application
    Filed: May 15, 2009
    Publication date: September 10, 2009
    Applicant: ALBANY MOLECULAR RESEARCH, INC.
    Inventors: Zhicai YANG, David D. MANNING
  • 2-alkylbenzoxazole carboxamides as 5-HTmodulators
    Patent number: 7553846
    Abstract: Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds are useful in treating CINV, IBS-D and other diseases and conditions.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: June 30, 2009
    Assignee: Albany Molecular Research, Inc.
    Inventors: Zhicai Yang, David D. Manning
  • Cyclosporins
    Patent number: 7538084
    Abstract: The compounds of the present invention are represented by the chemical structure found in Formula I: Formula I where A is an amino acid of Formula II: or a pharmaceutically acceptable salt thereof, with R0, R1, B, C, D, E, F, G, H, I, J, and K defined herein.
    Type: Grant
    Filed: March 16, 2004
    Date of Patent: May 26, 2009
    Assignee: AMR Technology, Inc.
    Inventors: Bruce F. Molino, Simon N. Haydar, Zhicai Yang, Peter C. Michels, Michael S. Hemenway, Joseph O. Rich, Yuri Khmelnitsky
  • Cyclosporin analogues and their pharmaceutical uses
    Patent number: 7511013
    Abstract: The compounds of the present invention are represented by Formula I, as shown below: or a pharmaceutically acceptable salt thereof, with X, R0, R1, and R2 defined herein.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: March 31, 2009
    Assignee: AMR Technology, Inc.
    Inventors: Bruce F. Molino, Zhicai Yang
  • 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS
    Publication number: 20080255114
    Abstract: Compounds of formulae I, II and III: are disclosed as 5-HT3 inhibitors. The compounds are useful in treating CINV, IBS-D and other diseases and conditions.
    Type: Application
    Filed: August 7, 2007
    Publication date: October 16, 2008
    Applicant: AMR TECHNOLOGY, INC.
    Inventors: Zhicai Yang, David D. Manning
  • CYCLOSPORIN ALKYNE ANALOGUES AND THEIR PHARMACEUTICAL USES
    Publication number: 20080249002
    Abstract: The compounds of the present invention are represented by the chemical structure found in Formula I: or a pharmaceutically acceptable salt thereof, with X, R0, R1, and R2 defined herein.
    Type: Application
    Filed: April 15, 2008
    Publication date: October 9, 2008
    Applicant: AMR TECHNOLOGY, INC.
    Inventors: Bruce F. Molino, Zhicai Yang
  • 2-ALKYLBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS
    Publication number: 20080214601
    Abstract: Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds are useful in treating CINV, IBS-D and other diseases and conditions.
    Type: Application
    Filed: August 7, 2007
    Publication date: September 4, 2008
    Applicant: AMR Technology, Inc.
    Inventors: Zhicai Yang, David D. Manning
  • NOVEL CYCLOSPORIN ALKYNES AND THEIR UTILITY AS PHARMACEUTICAL AGENTS
    Publication number: 20080153744
    Abstract: The compounds of the present invention are represented by the chemical structure found in Formula I: or a pharmaceutically acceptable salt thereof, with X, Ro, and R1 defined herein.
    Type: Application
    Filed: March 12, 2008
    Publication date: June 26, 2008
    Applicant: AMR TECHNOLOGY, INC.
    Inventors: Bruce F. Molino, Zhicai YANG
  • Cyclosporin alkyne analogues and their pharmaceutical uses
    Patent number: 7378391
    Abstract: The compounds of the present invention are represented by the chemical structure found in Formula I: or a pharmaceutically acceptable salt thereof, with X, R0, R1, and R2 defined herein.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: May 27, 2008
    Assignee: AMR Technology, Inc.
    Inventors: Bruce F. Molino, Zhicai Yang
  • Benzoxazole Carboxamides For Treating CINV and IBS-D
    Publication number: 20080108609
    Abstract: Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds that exhibit central activity are useful in treating CINV; those that inhibit peripheral receptors are useful to treat IBS-D.
    Type: Application
    Filed: November 2, 2007
    Publication date: May 8, 2008
    Applicant: AMR TECHNOLOGY, INC.
    Inventors: David Fairfax, Zhicai Yang
  • Cyclosporin alkynes and their utility as pharmaceutical agents
    Patent number: 7361636
    Abstract: The compounds of the present invention are represented by the chemical structure found in Formula I: or a pharmaceutically acceptable salt thereof, with X, R0, and R1 defined herein.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: April 22, 2008
    Assignee: AMR Technology, Inc.
    Inventors: Bruce F. Molino, Zhicai Yang
  • NOVEL PROCESSES FOR STEREOSELECTIVE SYNTHESIS OF TRANS ISATX247
    Publication number: 20080021197
    Abstract: The present invention relates to a process for preparation of a trans ISATX247 compound of the formula: where R1?H or D; R2?H or D; and R3?H or D, by application of organozirconium chemistry. The process involves reacting an acetyl cyclosporin aldehyde with an organozirconium reagent to provide acetyl cyclosporin diene (the acetate of trans ISATX247) and deacetylating the acetyl cyclosporin diene to produce the trans-isomer of ISATX247. The present invention also relates to a process for preparing the same trans ISATX 247 compound, using olefin cross metathesis. The process involves: olefin cross metathesis of acetyl cyclosporin A to afford acetyl cyclosporin ?,?-unsaturated aldehyde; Wittig reaction of the acetyl cyclosporin ?,?-unsaturated aldehyde to provide acetyl cyclosporin diene; and deacetylation of the acetyl cyclosporin diene to produce the trans ISATX247 compound.
    Type: Application
    Filed: July 26, 2005
    Publication date: January 24, 2008
    Inventors: Bruce Molino, Zhicai Yang, Jun-Ho Maeng, David Manning