Patents by Inventor Zhicang YE
Zhicang YE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11779663Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.Type: GrantFiled: November 9, 2020Date of Patent: October 10, 2023Assignee: HANGZHOU DAC BIOTECH CO., LTD.Inventors: Robert Yongxin Zhao, Qingliang Yang, Yuanyuan Huang, Shun Gai, Linyao Zhao, Hangbo Ye, Huihui Guo, Qianqian Tong, Minjun Cao, Junxiang Jia, Chengyu Yang, Wenjun Li, Xiaomai Zhou, Hongsheng Xie, Chen Lin, Zhixiang Guo, Zhicang Ye
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Publication number: 20230010108Abstract: The present invention relates to a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (a dual-linker) containing a 2,3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.Type: ApplicationFiled: October 12, 2018Publication date: January 12, 2023Applicant: Hangzhou DAC Biotech Co., Ltd.Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Linyao ZHAO, Hangbo YE, Xiaotao ZHUO, Chengyu YANG, Jun LEI, Yifang XU, Huihui GUO, Wenjun LI, Shun GAI, Lu BAI, Zhixiang GUO, Junxiang JIA, Jun ZHENG, Xiaomai ZHOU, Hongsheng XIE, Qianqian TONG, Mingjun CHAO, Yanhong TONG, Zhicang YE, Chen LIN, Yanlei YANG, Binbin CHEN
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Publication number: 20230001001Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.Type: ApplicationFiled: July 30, 2021Publication date: January 5, 2023Applicant: Hangzhou DAC Biotech Co., Ltd.Inventors: Robert Yongxin ZHAO, Yuanyuan HUANG, Qingliang YANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Yifang XU, Huihui GUO, Minjun CHAO, Qianqian TONG, Wenjun LI, Xiang CAI, Xiaomai ZHOU, Hongsheng XIE, Junxiang JIA, Haifeng ZHU, Zhixiang GUO, Shuihong GAO, Chunyan WANG, Chen LIN, Yanlei YANG, Zhicang YE, Jie PENG, Jun XU, Xiaotao ZUO, Qingyu SU
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Publication number: 20220378951Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.Type: ApplicationFiled: June 23, 2021Publication date: December 1, 2022Applicant: Hangzhou DAC Biotech Co., Ltd.Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Linyao ZHAO, Hangbo YE, Huihui GUO, Qianqian TONG, Minjun CAO, Junxiang JIA, Chengyu YANG, Wenjun LI, Xiaomai ZHOU, Hongsheng XIE, Chen LIN, Zhixiang GUO, Zhicang YE
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Publication number: 20210393790Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.Type: ApplicationFiled: July 30, 2021Publication date: December 23, 2021Applicant: Hangzhou DAC Biotech Co., Ltd.Inventors: Robert Yongxin ZHAO, Yuanyuan HUANG, Qingliang YANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Yifang XU, Huihui GUO, Minjun CHAO, Qianqian TONG, Wenjun LI, Xiang CAI, Xiaomai ZHOU, Hongsheng XIE, Junxiang JIA, Haifeng ZHU, Zhixiang GUO, Shuihong GAO, Chunyan WANG, Chen LIN, Yanlei YANG, Zhicang YE, Jie PENG, Jun XU, Xiaotao ZUO, Qingyu SU
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Publication number: 20210369855Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.Type: ApplicationFiled: July 28, 2021Publication date: December 2, 2021Applicant: Hangzhou DAC Biotech Co., Ltd.Inventors: Robert Yongxin ZHAO, Yuanyuan HUANG, Qingliang YANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Yifang XU, Huihui GUO, Minjun CHAO, Qianqian TONG, Wenjun LI, Xiang CAI, Xiaomai ZHOU, Hongsheng XIE, Junxiang JIA, Haifeng ZHU, Zhixiang GUO, Shuihong GAO, Chunyan WANG, Chen LIN, Yanlei YANG, Zhicang YE, Jie PENG, Jun XU, Xiaotao ZUO, Qingyu SU
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Publication number: 20210353777Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.Type: ApplicationFiled: July 13, 2021Publication date: November 18, 2021Applicant: Hangzhou DAC Biotech Co., Ltd.Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Linyao ZHAO, Hangbo YE, Huihui GUO, Qianqian TONG, Minjun CAO, Junxiang JIA, Chengyu YANG, Wenjun LI, Xiaomai ZHOU, Hongsheng XIE, Chen LIN, Zhixiang GUO, Zhicang YE
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Publication number: 20210346523Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.Type: ApplicationFiled: July 13, 2021Publication date: November 11, 2021Applicant: Hangzhou DAC Biotech Co., Ltd.Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Linyao ZHAO, Hangbo YE, Huihui GUO, Qianqian TONG, Minjun CAO, Junxiang JIA, Chengyu YANG, Wenjun LI, Xiaomai ZHOU, Hongsheng XIE, Chen LIN, Zhixiang GUO, Zhicang YE
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Patent number: 11129910Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.Type: GrantFiled: February 4, 2016Date of Patent: September 28, 2021Assignee: HANGZHOU DAC BIOTECH CO., LTD.Inventors: Robert Yongxin Zhao, Qingliang Yang, Yuanyuan Huang, Shun Gai, Linyao Zhao, Hangbo Ye, Huihui Guo, Qianqian Tong, Minjun Cao, Junxiang Jia, Chengyu Yang, Wenjun Li, Xiaomai Zhou, Hongsheng Xie, Chen Lin, Zhixiang Guo, Zhicang Ye
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Publication number: 20210169896Abstract: The present invention relates to novel cross-linked cytotoxic agents, pyrrolobenzodiazepine dimer (PBD) derivatives, and their conjugates to a cell-binding molecule, a method for preparation of the conjugates and the therapeutic use of the conjugates.Type: ApplicationFiled: July 5, 2018Publication date: June 10, 2021Inventors: Robert Yongxin ZHAO, Xiaotao ZHUO, Qingliang YANG, Linyao ZHAO, Yuanyuan HUANG, Hangbo YE, Chengyu YANG, Jun LEI, Shun GAI, Huihui GUO, Junxiang JIA, Lu BAI, Hongsheng XIE, Xiaomai ZHOU, Zhixiang GUO, Wenjun LI, Mingjun CAO, Jun ZHENG, Zhicang YE, Yanlei YANG
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Publication number: 20210052747Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)-or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.Type: ApplicationFiled: November 9, 2020Publication date: February 25, 2021Applicant: Hangzhou DAC Biotech Co., Ltd.Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Linyao ZHAO, Hangbo YE, Huihui GUO, Qianqian TONG, Minjun CAO, Junxiang JIA, Chengyu YANG, Wenjun LI, Xiaomai ZHOU, Hongsheng XIE, Chen LIN, Zhixiang GUO, Zhicang YE
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Publication number: 20200215206Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.Type: ApplicationFiled: February 4, 2016Publication date: July 9, 2020Applicants: SUZHOU M-CONJ BIOTECH CO., LTD., HANGZHOU DAC BIOTECH CO., LTD.Inventors: Robert Yongxin Zhao, Qingliang Yang, Yuanyuan Huang, Shun Gai, Linyao Zhao, Hangbo Ye, Huihui Guo, Qianqian Tong, Minjun Cao, Junxiang Jia, Chengyu Yang, Wenjun Li, Xiaomai Zhou, Hongsheng Xie, Chen Lin, Zhixiang Guo, Zhicang Ye
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Publication number: 20200069814Abstract: A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease. wherein “” is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.Type: ApplicationFiled: April 6, 2017Publication date: March 5, 2020Applicant: Hangzhou DAC Biotech Co., Ltd.Inventors: Robert Yongxin ZHAO, Yuanyuan HUANG, Qingliang YANG, Shun GAI, Hangbo YE, Linyao ZHAO, Chengyu YANG, Yifang XU, Huihui GUO, Minjun CHAO, Qianqian TONG, Wenjun LI, Xiang CAI, Xiaomai ZHOU, Hongsheng XIE, Junxiang JIA, Haifeng ZHU, Zhixiang GUO, Shuihong GAO, Chunyan WANG, Chen LIN, Yanlei YANG, Zhicang YE, Jie PENG, Jun XU, Xiaotao ZUO, Qingyu SU