Abstract: A method and system of detecting the activity of “bots” in an online community, by measuring the time elapsed between user actions and comparing this time to a timespan established as normal for users performing the same user actions without the assistance of bots. The timespan may be adjusted when other suspicion characteristics are detected. When detecting actions suspected to be bot-assisted, the method and system respond by executing one or more response instructions against the user suspected of using the bot, with the aim of preventing further bot activity. The response instructions are stored by associating them with a type of user action and a total number of suspect user actions. As a result, the response instructions may be set to increase in severity with each additional suspect act by a user.

Abstract: A method and system of detecting the activity of “bots” in an online community, by measuring the time elapsed between user actions and comparing this time to a timespan established as normal for users performing the same user actions without the assistance of bots. The timespan may be adjusted when other suspicion characteristics are detected. When detecting actions suspected to be bot-assisted, the method and system respond by executing one or more response instructions against the user suspected of using the bot, with the aim of preventing further bot activity. The response instructions are stored by associating them with a type of user action and a total number of suspect user actions. As a result, the response instructions may be set to increase in severity with each additional suspect act by a user.

Abstract: Minimal Motifs of linear B-cell epitopes in L1 structure protein from human papillomavirus type 58 (HPV 58) and their applications are disclosed. Eighteen linear epitope motifs and their extended 8-mer peptides in the L1 protein from HPV 58 are described, which can be used as antigens separately or in combination to specifically detect the serum from subjects with HPV 58 infection, or to develop preventive or therapeutic multi-epitope peptide vaccines against HPV 58 by inducing humoral immunity. Of the eighteen B-cell epitope motifs, ten of them are 100% conservative and one is highly conservative among many homologous proteins of high-risk HPVs. They can be used as candidate “universal” epitopes to develop preventive or therapeutic HPV vaccines. The amino acid sequences of the epitope motifs and the 8-mer peptide formula of the invention are shown below in SEQ ID No. 1-2, 2B, 3, 3B, 4-18, 18B, 19, 19B, and 20-32.

Abstract: Minimal Motifs of linear B-cell epitopes in L1 structure protein from human papillomavirus type 58 (HPV 58) and their applications are disclosed. Eighteen linear epitope motifs and their extended 8-mer peptides in the L1 protein from HPV 58 are described, which can be used as antigens separately or in combination to specifically detect the serum from subjects with HPV 58 infection, or to develop preventive or therapeutic multi-epitope peptide vaccines against HPV 58 by inducing humoral immunity. Of the eighteen B-cell epitope motifs, ten of them are 100% conservative and one is highly conservative among many homologous proteins of high-risk HPVs. They can be used as candidate “universal” epitopes to develop preventive or therapeutic HPV vaccines. The amino acid sequences of the epitope motifs and the 8-mer peptide formula of the invention are shown below in SEQ ID No. 1-2, 2B, 3, 3B, 4-18, 18B, 19, 19B, and 20-32.