Abstract: A sulfonamide pharmaceutical composition. The present invention relates to a sulfonamide compound injectable preparation comprising a sulfonamide compound or a derivative thereof. The injectable preparation is prepared from the sulfonamide compound and a pharmaceutically acceptable carrier through certain preparation technologies. The sulfonamide compound injectable preparation involved in the present invention is stable and controllable in quality and effective.

Abstract: A FEA model representing a product/part with certain finite elements for metal portion, metal necking failure criteria (critical and fracture strain values defined in form of loading path diagram) and the neck's characteristics (neck's width and a profile of strain values within the width) are received in a computer system. At each solution cycle of a time-marching simulation of a deep draw metal forming process using the FEA model, following operations are performed at each integration point of every finite element: identifying major and minor strain values and corresponding directions from the computed strain values, calculating an equivalent metal necking failure strain value (?e) in the major strain direction with a formula based on corresponding critical and fracture strain values, the neck's characteristics and a characteristic dimension in the major strain direction, and determining metal necking failure, which occurs when the major strain value is greater than ?e.

Abstract: Systems and methods of calculating friction/tied-interface effects in time-marching simulation for improvement of a product/part are disclosed. FEA model, representing a product/part, contains first and second sub-models connected with each other via a friction/tied-interface. The friction/tied-interface connects at least one perimeter nodal point in the first sub-model to at least one element face in the second sub-model. Each perimeter nodal point is associated with a particular one of the at least one element face. Numerically-calculated structural behaviors of the product/part under a design condition are obtained by conducting a time-marching simulation using the FEA model. Numerically-calculated structural behaviors at each of a number of solution cycle include effects from respective sets of counterbalance corner nodal forces applied on the at least one element face.

Abstract: A sulfonamide pharmaceutical composition. The present invention relates to a sulfonamide compound injectable preparation comprising a sulfonamide compound or a derivative thereof. The injectable preparation is prepared from the sulfonamide compound and a pharmaceutically acceptable carrier through certain preparation technologies. The sulfonamide compound injectable preparation involved in the present invention is stable and controllable in quality and effective.

Abstract: A FEA model representing a product/part with certain finite elements for metal portion, metal necking failure criteria (critical and fracture strain values defined in form of loading path diagram) and the neck's characteristics (neck's width and a profile of strain values within the width) are received in a computer system. At each solution cycle of a time-marching simulation of a deep draw metal forming process using the FEA model, following operations are performed at each integration point of every finite element: identifying major and minor strain values and corresponding directions from the computed strain values, calculating an equivalent metal necking failure strain value (?e) in the major strain direction with a formula based on corresponding critical and fracture strain values, the neck's characteristics and a characteristic dimension in the major strain direction, and determining metal necking failure, which occurs when the major strain value is greater than ?e.

Abstract: Methods and systems for numerically simulating structural behaviors of a product are disclosed. FEA model representing a product is received in a computer system. FEA model contains nodal points connected by first order non-“volumetric-locking” (FONVL) finite elements. Each FONVL finite element is configured with volumetric DOFs at respective boundaries. Numerically-simulated structural behaviors of the product are obtained by conducting a time-marching simulation using the FEA model. At each solution cycle of the simulation for each FONVL finite element, calculating volumetric variations at the respective boundaries based on corresponding one of the volumetric DOFs; and then solving unknown coefficients of a linear formula that defines each FONVL finite element's volumetric strain distribution using the calculated volumetric variations along with representative coordinates of the respective boundaries.

Abstract: Methods and systems for specifying metal necking failure criteria in FEA are disclosed. FEA model contains many finite elements representing a structure, a loading condition and a metal necking failure criteria are received in a computer system. The loading condition includes a loading direction. The metal necking failure criteria includes critical strain and fracture strain values, the neck's width, and a profile of strain values between the critical strain value and the fracture strain value within the neck's width. At each solution cycle in the time-marching simulation of the structure, each finite element is check to determine whether it experiences a metal necking failure, which occurs when each finite element's strain obtained in that solution cycle is greater than an average strain value defined in a formula according to the critical strain and fracture strain values, the neck's width and the profile of the metal necking failure criteria.

Abstract: A sulfonamide pharmaceutical composition. The present invention relates to a sulfonamide compound injectable preparation comprising a sulfonamide compound or a derivative thereof. The injectable preparation is prepared from the sulfonamide compound and a pharmaceutically acceptable carrier through certain preparation technologies. The sulfonamide compound injectable preparation involved in the present invention is stable and controllable in quality and effective.

Abstract: FEA model contains first and second layers of nodes to form a group of node-pairs, each containing one node in the first layer and a corresponding node in the second layer. Nodes in each node-pair are located in a substantially closer distance comparing with distances to other nodes. Candidate finite elements for controlling time-step size are identified. Each candidate finite element is defined by one or more node-pairs. At each solution cycle of a time-marching simulation, nodal forces of the FEA model including candidate finite elements are obtained. A scaled dimension is calculated by multiplying the smallest dimension with a speed-up scale factor. A critical dimension for controlling the next solution cycle's time-step size is then determined. A fraction of the corresponding nodal forces to be redistributed for maintaining a stable solution are calculated and redistributed according to a formula based nodal masses and speed-up scale factor.

Abstract: Methods and systems for specifying metal necking failure criteria in FEA are disclosed. FEA model contains many finite elements representing a structure, a loading condition and a metal necking failure criteria are received in a computer system. The loading condition includes a loading direction. The metal necking failure criteria includes critical strain and fracture strain values, the neck's width, and a profile of strain values between the critical strain value and the fracture strain value within the neck's width. At each solution cycle in the time-marching simulation of the structure, each finite element is check to determine whether it experiences a metal necking failure, which occurs when each finite element's strain obtained in that solution cycle is greater than an average strain value defined in a formula according to the critical strain and fracture strain values, the neck's width and the profile of the metal necking failure criteria.

Abstract: A FEA model, representing a structure, contains at least many finite elements for metal portion, a set of metal necking failure criteria (critical and fracture strain values defined in form of a loading path diagram) and the neck's characteristics (neck's width and a profile of strain values within the width) are received in a computer system. At each solution cycle of a time-marching simulation using the FEA model, following operations are performed at each integration point of every finite element: identifying major and minor strain values and corresponding directions from the computed strain values, calculating an equivalent metal necking failure strain value (?e) in the major strain direction with a formula based on corresponding critical and fracture strain values, the neck's characteristics and a characteristic dimension with respect to the major strain direction, and determining metal necking failure, which occurs when the major strain value is greater than ?e.

Abstract: Systems and methods for creating a computerized model containing polydisperse spherical particles packed in an arbitrarily-shaped volume are disclosed. To create the computerized model, a plurality of polydisperse spherical particles having statistical properties according the characteristic profile (e.g., minimum and maximum sizes and size distribution) is generated. First portion of the particles is used for forming a border layer within the volume's boundary. Any hole in the border layer is sealed with one or more null-sized particles. Second portion of the particles is used for filling up an interior space in a layer-to-layer scheme from the border layer inwards. The layer-to-layer scheme includes searching a best suitable location from a list of size-ranked candidate locations using power diagrams. Each of the second portion of the particles is allowed to pass through holes in the current layer towards the border layer when possible.

Abstract: Systems and methods of providing bonded-particle model amongst a plurality of discrete particles representing a physical domain made of brittle material in a time-marching simulation to obtain numerically simulated continuum physical phenomena are disclosed. A physical domain is represented by a plurality of discrete particles. A domain of influence is assigned to each discrete particle and a bonded-particle model is created for the discrete particles. Respective bonds are established to connect each discrete particle to all other discrete particles within its domain of influence. The bonded-particle model further defines a rule for breakage of a bond. Continuum physical phenomena of the physical domain are numerically represented through a set of formula such that a time-marching simulation of the physical domain can be conducted. Physical properties include material properties and fracture energy release rate. Finally, the bonded-particle model allows size and orientation changes of each discrete particle.

Abstract: A bond model in DEM is disclosed. The model includes receiving initial location, volume, mass density, bulk shear moduli of discrete particles representing physical domain made of heterogeneous material; assigning an influence range to each discrete particle; establishing a plurality of bonds for connecting the discrete particles, each of the bonds is divided into first and second sub-bonds with the first sub-bond connecting to a first discrete particle and the second sub-bond connecting to a second discrete particle, the said first and second discrete particles are located within the influence range. Each discrete particle is connected to one or more sub-bonds; dividing the volume of each discrete particle into one or more sub-bonds so that one or more sub-bonds are assigned with properties that include length and cross-section area; and obtaining numerically simulated physical phenomena within the physical domain by conducting a time-marching simulation of the bonds with assigned properties.

Abstract: Systems and methods of providing bonded-particle model amongst a plurality of discrete particles representing a physical domain made of brittle material in a time-marching simulation to obtain numerically simulated continuum physical phenomena are disclosed. A physical domain is represented by a plurality of discrete particles. A domain of influence is assigned to each discrete particle and a bonded-particle model is created for the discrete particles. Respective bonds are established to connect each discrete particle to all other discrete particles within its domain of influence. The bonded-particle model further defines a rule for breakage of a bond. Continuum physical phenomena of the physical domain are numerically represented through a set of formula such that a time-marching simulation of the physical domain can be conducted. Physical properties include material properties and fracture energy release rate. Finally, the bonded-particle model allows size and orientation changes of each discrete particle.

Abstract: Systems and methods for creating a computerized model containing polydisperse spherical particles packed in an arbitrarily-shaped volume are disclosed. To create the computerized model, a plurality of polydisperse spherical particles having statistical properties according the characteristic profile (e.g., minimum and maximum sizes and size distribution) is generated. First portion of the particles is used for forming a border layer within the volume's boundary. Any hole in the border layer is sealed with one or more null-sized particles. Second portion of the particles is used for filling up an interior space in a layer-to-layer scheme from the border layer inwards. The layer-to-layer scheme includes searching a best suitable location from a list of size-ranked candidate locations using power diagrams. Each of the second portion of the particles is allowed to pass through holes in the current layer towards the border layer when possible.