Patents by Inventor Zhigang Cheng

Zhigang Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for manufacturing a boronic acid ester compound
    Patent number: 8785651
    Abstract: The present invention relates to a method for manufacturing a boronic acid ester compound, characterized by reacting an aryl halide compound and a diboron ester compound in the presence of a nitrogen-containing organic base, a nickel catalyst, a phosphine compound and a solvent. According to the manufacturing method of the present invention, even if a nickel catalyst is used as the catalyst, a desired boronic acid ester compound can be obtained in a sufficiently high yield. Furthermore, even if aryl chloride or aryl bromide having relatively low price and low reactivity, was used as the aryl halide compound, a desired boronic acid ester compound can be obtained in a sufficiently high yield.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: July 22, 2014
    Assignees: Sumitomo Chemical Company, Limited, Genentech, Inc.
    Inventors: Takashi Miki, Yasuharu Shimasaki, Srinivasan Babu, Zhigang Cheng, Mark E. Reynolds, Qingping Tian
  • PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS
    Publication number: 20140100366
    Abstract: Process methods for making the dual mTOR/PI3K inhibitor GDC-0980, named as (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one, having the structure: and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: October 9, 2013
    Publication date: April 10, 2014
    Applicant: Genentech, Inc.
    Inventors: Srinivasan Babu, Zhigang Cheng, Francis Gosselin, Pirmin Hidber, Ursula Hoffmann, Theresa Humphries, Reinhard Reents, Qingping Tian, Herbert Yajima
  • Process for making thienopyrimidine compounds
    Patent number: 8431694
    Abstract: The invention provides processes of preparing, separating, and purifying PI3K inhibitor, Formula I and II compounds, and novel intermediates for preparing Formula I and II compounds.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: April 30, 2013
    Assignee: Genentech, Inc.
    Inventors: Srinivasan Babu, Zhigang Cheng, Mark E. Reynolds, Scott J. Savage, Qingping Tian, Herbert Yajima
  • High current magnetic component and methods of manufacture
    Patent number: 8400245
    Abstract: Magnetic components including pre-formed clips are described that are more amenable to production on a miniaturized scale. Discrete core pieces can be assembled with pre-formed coils and physically gapped from one another with more efficient manufacturing techniques.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: March 19, 2013
    Assignee: Cooper Technologies Company
    Inventors: Yipeng Yan, Robert James Bogert, Guo Ouyang, Zhigang Cheng
  • Process for making thienopyrimidine compounds
    Patent number: 8354528
    Abstract: The invention provides processes of preparing, separating, and purifying PI3K inhibitor, Formula (I) and (II) compounds, and novel intermediates for preparing Formula (I) and (II) compounds.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: January 15, 2013
    Assignee: Genentech, Inc.
    Inventors: Srinivasan Babu, Zhigang Cheng, Mark E. Reynolds, Scott J. Savage, Qingping Tian, Herbert Yajima
  • METHOD FOR MANUFACTURING A BORONIC ACID ESTER COMPOUND
    Publication number: 20120123122
    Abstract: The present invention relates to a method for manufacturing a boronic acid ester compound, characterized by reacting an aryl halide compound and a diboron ester compound in the presence of a nitrogen-containing organic base, a nickel catalyst, a phosphine compound and a solvent. According to the manufacturing method of the present invention, even if a nickel catalyst is used as the catalyst, a desired boronic acid ester compound can be obtained in a sufficiently high yield. Furthermore, even if aryl chloride or aryl bromide having relatively low price and low reactivity, was used as the aryl halide compound, a desired boronic acid ester compound can be obtained in a sufficiently high yield.
    Type: Application
    Filed: March 24, 2009
    Publication date: May 17, 2012
    Applicants: GENENTECH, INC., SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Takashi Miki, Yasuharu Shimasaki, Srinivasan Babu, Zhigang Cheng, Mark E. Reynolds, Qingping Tian
  • PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS
    Publication number: 20100292468
    Abstract: The invention provides processes of preparing, separating, and purifying PI3K inhibitor, Formula (I) and (II) compounds, and novel intermediates for preparing Formula (I) and (II) compounds.
    Type: Application
    Filed: October 24, 2008
    Publication date: November 18, 2010
    Inventors: Srinivasan Babu, Zhigang Cheng, Mark E. Reynolds, Scott J. Savage, Qingping Tian, Herbert Yajima
  • HIGH CURRENT MAGNETIC COMPONENT AND METHODS OF MANUFACTURE
    Publication number: 20100013587
    Abstract: Magnetic components including pre-formed clips are described that are more amenable to production on a miniaturized scale. Discrete core pieces can be assembled with pre-formed coils and physically gapped from one another with more efficient manufacturing techniques.
    Type: Application
    Filed: August 5, 2009
    Publication date: January 21, 2010
    Inventors: Yipeng Yan, Robert James Bogert, Guo Ouyang, Zhigang Cheng