Patents by Inventor Zhigang Wang

Zhigang Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LONG-ACTING AND LOW-TOXIC RECOMBINANT ANTI-VEGF HUMANIZED MONOCLONAL ANTIBODY AND PRODUCTION METHOD THEREFOR
    Publication number: 20210079081
    Abstract: The present invention relates to a full length humanized monoclonal antibody that can specifically bind to VEGF. The antibody can inhibit binding of VEGF to VEGFR-1 and VEGFR-2, thereby inhibiting signaling of VEGF. The antibody has a strong affinity for VEGF, has a long half-life, and is highly safe after vitreous injection. The antibody of the invention may be effective in treating diseases associated with VEGF overexpression, particularly diseases associated with abnormal angiogenesis caused by VEGF overexpression.
    Type: Application
    Filed: January 4, 2019
    Publication date: March 18, 2021
    Applicant: BIO-THERA SOLUTIONS, LTD.
    Inventors: Xiaoyun Wu, Chenchao Xu, Zhigang Wang, Shengfeng Li
  • Platinum complex, its preparation and therapeutic use
    Patent number: 10899781
    Abstract: A platinum complex includes a structure of Formula (I). A method for treating a subject suffering from cancer includes a step of administering an effective amount of the platinum complex to the subject. A method for inhibiting the growth of cancer cells includes the step of contacting a population of cancer cells with an effective amount of the platinum complex. The platinum complexes are particularly suitable for treatment of cancer through, in particular, photodynamic therapy.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: January 26, 2021
    Assignee: City University of Hong Kong
    Inventors: Guangyu Zhu, Zhigang Wang, Zoufeng Xu
  • Method and apparatus for signal interference processing
    Patent number: 10904890
    Abstract: A system that incorporates the subject disclosure may include, for example, a method for measuring a power level in at least a portion of a plurality of resource blocks occurring in a radio frequency spectrum, wherein the measuring occurs for a plurality of time cycles to generate a plurality of power level measurements, calculating a baseline power level according to at least a portion of the plurality of power levels, determining a threshold from the baseline power level, and monitoring at least a portion of the plurality of resource blocks for signal interference according to the threshold. Other embodiments are disclosed.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: January 26, 2021
    Assignee: ISCO International, LLC
    Inventors: Amr Abdelmonem, Mikhail Galeev, Sean S. Cordone, Zhigang Wang, Howard Wong, Jorge Seoane
  • METHOD AND APPARATUS FOR INCREASING PERFORMANCE OF COMMUNICATION LINKS OF COMMUNICATION NODES
    Publication number: 20210022085
    Abstract: A system that incorporates aspects of the subject disclosure may perform operations including, for example, obtaining performance parameters in a communications network, identifying a degradation in performance of one or more nodes of the communications network according the monitored performance parameters, and initiating corrective action to mitigate the degradation in performance of the one or more nodes of the communications network. Other embodiments are disclosed.
    Type: Application
    Filed: October 2, 2020
    Publication date: January 21, 2021
    Applicant: ISCO International, LLC
    Inventors: Amr Abdelmonem, Jorge Seoane, Mikhail Galeev, Krishna Komoravolu, Zhigang Wang, Gordon Reichard, JR.
  • ADJUSTING SIGNAL POWER TO INCREASE PERFORMANCE OF COMMUNICATION LINKS OF COMMUNICATION NODES
    Publication number: 20210022086
    Abstract: A system that incorporates aspects of the subject disclosure may perform operations including, for example, identifying a selection of a SINR measurement target of a number of different SINR measurement targets. A SINR measurement of a second base station based on the SINR measurement target is obtained prior to a changing of an amplitude of a portion of a signal of a first base station. A determination is made as to whether the changing of the amplitude of the portion of the signal has reduced a second average SINR measurement of the second base station below a SINR threshold. In response to determining that the changing of the amplitude of the portion of the signal has reduced the second average SINR measurement of the second base station below the SINR threshold, the changing of the amplitude of the portion of the signal is reversed. Other embodiments are disclosed.
    Type: Application
    Filed: October 2, 2020
    Publication date: January 21, 2021
    Applicant: ISCO International, LLC
    Inventors: Amr Abdelmonem, William A. Myers, Ted Myers, Jorge Seoane, Mikhail Galeev, Krishna Komoravolu, Zhigang Wang, Gordon Reichard, JR.
  • Method and apparatus for increasing performance of communication links of communication nodes
    Patent number: 10834683
    Abstract: A system that incorporates aspects of the subject disclosure may perform operations including, for example, obtaining performance parameters in a communications network, identifying a degradation in performance of one or more nodes of the communications network according the monitored performance parameters, and initiating corrective action to mitigate the degradation in performance of the one or more nodes of the communications network. Other embodiments are disclosed.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: November 10, 2020
    Assignee: ISCO International, LLC
    Inventors: Amr Abdelmonem, Jorge Seoane, Mikhail Galeev, Krishna Komoravolu, Zhigang Wang, Gordon Reichard, Jr.
  • Adjusting signal power to increase performance of communication links of communication nodes
    Patent number: 10834684
    Abstract: A system that incorporates aspects of the subject disclosure may perform operations including, for example, obtaining performance measurements for a number of sectors or a number of paths and determining whether one or more of the performance measurements are below a threshold. A power level of at least a portion of a received uplink signal is adjusted to increase a performance measurement of an affected sector of the number of sectors or an affected path of the number of paths falling below the threshold. A determination is made as to whether the adjusting of the power level of at least the portion of the received uplink signal has improved the performance measurement of the affected sector or the affected path. Other embodiments are disclosed.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: November 10, 2020
    Assignee: ISCO International, LLC
    Inventors: Amr Abdelmonem, William A. Myers, Ted Myers, Jorge Seoane, Mikhail Galeev, Krishna Komoravolu, Zhigang Wang, Gordon Reichard, Jr.
  • PEDESTRIAN RE-IDENTIFICATION METHOD, COMPUTER DEVICE AND READABLE MEDIUM
    Publication number: 20200342271
    Abstract: The present disclosure provides a pedestrian re-identification method and apparatus, computer device and readable medium. The method comprises: collecting a target image and a to-be-identified image including a pedestrian image; obtaining a feature expression of the target image and a feature expression of the to-be-identified image respectively, based on a pre-trained feature extraction model; wherein the feature extraction model is obtained by training based on a self-attention feature of a base image as well as a co-attention feature of the base image relative to a reference image; identifying whether a pedestrian in the to-be-identified image is the same pedestrian as that in the target image according to the feature expression of the target image and the feature expression of the to-be-identified image.
    Type: Application
    Filed: March 12, 2020
    Publication date: October 29, 2020
    Applicant: BEIJING BAIDU NETCOM SCIENCE AND TECHNOLOGY CO., LTD.
    Inventors: Zhigang WANG, Jian WANG, Shilei WEN, Errui DING, Hao SUN
  • DESIGN FOR INTERNAL COOLING PASSAGES FOR ROTATING CUTTING TOOLS
    Publication number: 20200338649
    Abstract: A cutting tool comprising a tool body comprising a shank and a cutter opposite the shank, the body defining a length from a shank end to an end face opposite the shank end, a central axis extends along the length of the body; at least one tooth having a cutting edge, the cutting edge extending along the tooth from the shank to the end face; a flute formed adjacent the at least one tooth; at least one cooling channel formed in the tooth proximate the at least one cutting edge, the at least one cooling channel having an elongated cross sectional shape with an elliptical portion and a circular portion opposite the elliptical portion, wherein the elliptical portion is located proximate the cutting edge.
    Type: Application
    Filed: April 24, 2019
    Publication date: October 29, 2020
    Applicant: United Technologies Corporation
    Inventors: Zhigang Wang, Changsheng Guo, Robert W. Day, Gordon Miller Reed
  • Internal cooling passages for rotating cutting tools
    Patent number: 10814406
    Abstract: A cutting tool comprising a tool body comprising a shank and a cutter opposite the shank, the body defining a length from a shank end to an end face opposite the shank end, a central axis extends along the length of the body; at least one tooth having a cutting edge, the cutting edge extending along the tooth from the shank to the end face; a flute formed adjacent the at least one tooth; at least one cooling channel formed in the tooth proximate the at least one cutting edge, the at least one cooling channel having an elongated cross sectional shape with an elliptical portion and a circular portion opposite the elliptical portion, wherein the elliptical portion is located proximate the cutting edge.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: October 27, 2020
    Assignee: Raytheon Technologies Corporation
    Inventors: Zhigang Wang, Changsheng Guo, Robert W. Day, Gordon Miller Reed
  • Method and apparatus for increasing performance of a communication link of a communication node
    Patent number: 10820282
    Abstract: A system that incorporates aspects of the subject disclosure may perform operations including, for example, monitoring performance parameters in a communications network, identifying a degradation in performance of one or more nodes of the communications network according the monitored performance parameters, and initiating corrective action to mitigate the degradation in performance of the one or more nodes of the communications network. Other embodiments are disclosed.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: October 27, 2020
    Assignee: ISCO International, LLC
    Inventors: Amr Abdelmonem, Jorge Seoane, Mikhail Galeev, Krishna Komoravolu, Zhigang Wang, Gordon Reichard, Jr.
  • PREDICTIVE MAP GENERATION TECHNOLOGY
    Publication number: 20200333142
    Abstract: Systems, apparatuses and methods may provide for technology that generates a sequence of predictive maps based on a sequence of historical maps and overlays the sequence of predictive maps on one another to obtain a map overlay. The technology may also apply an attenuation factor to the map overlay. In one example, the map overlay includes a grid of cells and each cell includes an occupation probability in accordance with the attenuation factor.
    Type: Application
    Filed: January 10, 2018
    Publication date: October 22, 2020
    Inventors: Zhigang Wang, Ganmei You
  • Closed-loop fluid control to obtain efficient machining
    Patent number: 10807209
    Abstract: A system includes a machine tool that includes a cutting tool, a fluid subsystem that provides fluid to the cutting tool, and at least one processor that executes instructions that cause the at least one processor to: obtain a signal indicative of a load on the cutting tool, establish a first value of at least one parameter of the fluid based on the signal, obtain a second value of the at least one parameter that is based on a simulation, determine a difference between the first value and the second value, and adjust a state of a device of the fluid subsystem based on the determined difference.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: October 20, 2020
    Assignee: Raytheon Technologies Corporation
    Inventors: Zhigang Wang, Changsheng Guo, Daniel V. Viens
  • MULTI-BAND BASE STATION ANTENNAS HAVING INTEGRATED ARRAYS
    Publication number: 20200321700
    Abstract: Base station antennas are provided herein. A base station antenna includes a plurality of vertical columns of low-band radiating elements configured to transmit RF signals in a first frequency band. The base station antenna also includes a plurality of vertical columns of high-band radiating elements configured to transmit RF signals in a second frequency band that is higher than the first frequency band. The vertical columns of high-band radiating elements extend in parallel with the vertical columns of low-band radiating elements in a vertical direction.
    Type: Application
    Filed: March 25, 2020
    Publication date: October 8, 2020
    Inventors: Bo Wu, Martin L. Zimmerman, Björn Lindmark, Hangsheng Wen, PuLiang Tang, Jian Zhang, Xun Zhang, Ligang Wu, Zhigang Wang, Ruixin Su, Maosheng Liu, Rui An
  • Cooling system for rotating cutting tools
    Patent number: 10786853
    Abstract: A rotary tool includes a shank, cutting portion, coolant inlet, coolant outlet, and channel system. The cutting portion is connected to and extends from the shank. The cutting portion includes a cutting edge. The coolant inlet and the coolant outlet are disposed in the shank. The channel system is contained in the rotary tool and is a closed circulation loop system such that the coolant is contained within the channel system as the coolant is circulated within the rotary tool. The channel system includes a delivery path and a return path. The delivery path is fluidly connected to the coolant inlet and includes a shape corresponding to a shape of the cutting edge. The return path is fluidly connected to the coolant outlet and to the delivery path at a location in the cutting portion of the rotary tool.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: September 29, 2020
    Assignee: United Technologies Corporation
    Inventors: Zhigang Wang, Changsheng Guo
  • Technologies for LIDAR based moving object detection
    Patent number: 10782409
    Abstract: Technologies for monitoring a movement of one or more objects include an autonomous compute device. The autonomous compute device includes an optical system, for example, a LIDAR system, to capture optical data that may be used to determine a relative position of the one or more objects relative to the autonomous compute device. Based on the optical data captured at one point in time and an indication of how much the autonomous compute device has moved, the autonomous compute device may predict where an object will be relative to the autonomous compute device at a later point in time. Based on optical data captured at the later point in time, the autonomous compute device may determine whether the position of the object has been changed and further analyze the changes to monitor the movement of the object.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: September 22, 2020
    Assignee: Intel Corporation
    Inventors: Zhigang Wang, Bo Zhang
  • REAL-TIME IDENTIFICATION OF BURR SIZE AND LOCATION FOR ROBOTIC DEBURRING PROCESS
    Publication number: 20200290207
    Abstract: A process of deburring a workpiece comprising installing a workpiece onto a machine table proximate a robot, the workpiece having a surface, the robot having at least one force sensor and a spindle load sensor associated with a spindle coupled to a cutting tool, the robot having at least one joint configured to be actuated by a joint actuator; the robot being coupled to a controller; generating joint encoder signals with the controller, the joint encoder signals configured to direct the joint actuator; sensing contact forces between the cutting tool of the robot and the surface of the workpiece; determining a deburring path of the cutting tool to deburr the workpiece; and controlling the robotic deburring process by use of the joint encoder signals, a physics based model of burr size and material removal, a nominal trajectory and an actual trajectory of the cutting tool center point position.
    Type: Application
    Filed: March 11, 2019
    Publication date: September 17, 2020
    Applicant: United Technologies Corporation
    Inventors: Zhigang Wang, Michael A. Klecka, Abhijit Chakraborty, Jeffrey Michael Mendoza
  • GRID OCCUPANCY MAPPING USING ERROR RANGE DISTRIBUTION
    Publication number: 20200271787
    Abstract: A technology is described for mapping a physical environment. An example method may include receiving laser point data for laser light reflected from the physical environment and detected by a laser sensor. Points included in the laser point data can be correlated to grid cells in an environment map that represents the physical environment. Error ranges for the points correlated to the grid cells can be determined based in part on an error distribution. Occupation probabilities can then be calculated for the grid cells in the environment map using an interpolation technique and grid cell occupation probabilities for adjacent error grid cells selected based in part on the error ranges of the points, and the grid cells in the environment map can be updated with the occupation probabilities.
    Type: Application
    Filed: October 3, 2017
    Publication date: August 27, 2020
    Applicant: Intel Corporation
    Inventors: Ganmei You, Zhigang Wang, Dawei Wang, Hu Chen
  • Downhole drilling tool system of torque self-balancing
    Patent number: 10724300
    Abstract: The present invention relates to a downhole drilling tool system of torque self-balancing and belongs to a technical field of drilling engineering equipment. The drilling tool system consists of an assembly of internal and external drill bits, power components, a pressure adjustment system for internal and external drill bits, a mud circulating system, and an unfreezing system.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: July 28, 2020
    Assignee: Jilin University
    Inventors: Ke Gao, Youhong Sun, Zhigang Wang, Yan Zhao, Kun Bo, Xiaobo Xie, Haiyong Wang, Xiaochu Wang, Zhao Liu, Yafei Wang, Hangkai Chen, Saiyu Peng, Yingchao Xu, Lidong Xing
  • METHOD AND APPARATUS FOR SIGNAL INTERFERENCE PROCESSING
    Publication number: 20200236686
    Abstract: Aspects of the subject disclosure may include, for example, determining that a number of interferers in a portion of a number of spectral segments exceeds a number of filters of a number of filters. Use of the number of filters to filter interference is prioritized responsive to the number of interferers exceeding the number of filters. Interference is filtered in the portion of the number of spectral segments for suppressing at least a portion of the detected interference.
    Type: Application
    Filed: April 1, 2020
    Publication date: July 23, 2020
    Applicant: ISCO International, LLC
    Inventors: Mikhail Galeev, Amr Abdelmonem, Dariusz Seskiewicz, Zhigang Wang